摘要:
Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要:
Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要:
Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要:
Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要:
A crystal structure of PYK2 is described that was determined by X-ray crystallography. The use of PYK2 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PYK2.
摘要:
Methods and systems to automatically respond to consider the weight of a request when responding to requests associated with resources are described. In one embodiment, an interface module may be configured to receive a request associated with consumer identifier and a resource. A calculator module may be configured to determine a weight of the request and a usage module configured to calculate, using a processor, a usage level associated with the consumer identifier, the usage level based on a usage history associated with the consumer identifier. An enforcer module may also be configured to respond to the request based on the usage level and the weight of the request. In one embodiment, the usage module may also be configured to update the usage level associated with the consumer identifier based on the weight of the request.
摘要:
A method to detect potential problems within a heterogeneous and diverse application environment. Operations data is received from a plurality of application servers within the application environment. The operations data pertains to operations performed at the plurality of application servers over a predetermined time interval. The operations data is aggregated. The aggregated data is compared to reference data, and a potential problem within the application environment is detected if the aggregated data deviates from the reference data in a predetermined manner.
摘要:
In various exemplary embodiments, a system and a related method and a related computer-readable medium to perform the method, for tracking numerous software calls in an enterprise environment is provided. The method includes tracking, during a runtime operation of the enterprise environment, layers through which each of the software calls passes. The tracking includes logging each of a multitude of physical components involved in each of the software calls, annotating each of the physical components with associated metadata, logging each of a multitude of logical components involved in the software calls, annotating each of the logical components with associated metadata, and logging a reliance of each of the physical components and the logical components on other physical and logical components. A dependency map is generated indicating the layers tracked in each of the software calls.
摘要:
In various embodiments, a system and related method for organizing transactional data from a diverse and heterogeneous application environment is disclosed. In an example embodiment, a system includes a file system and one or more daemon indexers in electrical communication with the file system. The file system is arranged as a non-relational and serverless file system to allow for cost-effectiveness with ready scalability. The file system is to receive, in substantially real-time, unsorted transactional data from a publishing module. The one or more daemon indexers are arranged to receive the unsorted transactional data from the file system, organize the unsorted transactional data by operational characteristics, and store the organized transactional data on the file system.
摘要:
A computer-implemented system and method for the definition, creation, management, transmission, and monitoring of errors in a SOA environment. An example embodiment includes: defining a common standard error data structure; automatically generating a unique identifier (ID) for each new error data instance; allowing customization of error data structure through extensions; creation and management of error instances that conform to this structure; ability to group errors across various dimensions; introducing the concept of an error library, the error library including a plurality of localizable error bundles, each of the error bundles including a plurality of error data instances for a particular domain, along with the associated metadata; automatically creating runtime artifacts for each error; ability to transmit errors either as faults or as part of the normal response payload; automatic error metric collection based on various error categories, and finally, tooling to help manage error libraries and reporting errors.