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公开(公告)号：US20180206462A1
公开(公告)日：2018-07-26
申请号：US15926586
申请日：2018-03-20
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Elena Burova , Alexander O. Mujica , Ka-Man Venus Lai , Andrew J. Murphy
IPC: A01K67/027 , C12Q1/6886 , C07K14/47 , C07K16/28 , G01N33/50 , A61K49/00 , C07K14/435
CPC classification number: A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2267/0331 , A61K49/0008 , C07K14/435 , C07K14/4747 , C07K16/2803 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5038 , G01N2333/57 , G01N2333/70503 , G01N2500/10
Abstract: Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. The non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that the non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
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公开(公告)号：US09955677B2
公开(公告)日：2018-05-01
申请号：US14744592
申请日：2015-06-19
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Elena Burova , Alexander O. Mujica , Ka-Man Venus Lai , Andrew J. Murphy
IPC: A01K67/027 , C07H21/04 , C07K1/00 , A61K49/00 , C12Q1/68 , G01N33/50 , C07K16/28 , C07K14/47 , C07K14/435
Abstract: Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. The non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that the non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
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公开(公告)号：US09938345B2
公开(公告)日：2018-04-10
申请号：US14603808
申请日：2015-01-23
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Nicholas J. Papadopoulos , Andrew J. Murphy , Gavin Thurston , Ella Ioffe , Elena Burova
CPC classification number: C07K16/2827 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/30 , C07K2317/21 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The present invention provides antibodies that bind to the T-cell co-inhibitor ligand programmed death-ligand1 (PD-L1) protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that bind to PD-L1. In certain embodiments, the present invention provides multi-specific antigen-binding molecules comprising a first binding specificity that binds to PD-L1 and a second binding specificity that binds to a tumor cell antigen, an infected cell-specific antigen, or a T-cell co-inhibitor. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing PD-L1 activity, thus providing a means of treating a disease or disorder such as cancer or viral infection.
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公开(公告)号：US09913461B2
公开(公告)日：2018-03-13
申请号：US14963402
申请日：2015-12-09
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： Elena Burova , Yajun Tang , Ka-Man Venus Lai , Andrew J. Murphy
IPC: A01K67/027 , G01N33/00 , C12N15/00 , C07K14/705 , C07K16/30 , A61K49/00 , A61K39/00
CPC classification number: A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/02 , A01K2267/03 , A01K2267/0331 , A61K49/0008 , A61K2039/505 , C07K14/70596 , C07K16/30
Abstract: Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
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