公开(公告)号：US20130172320A1

公开(公告)日：2013-07-04

申请号：US13579912

申请日：2011-02-18

Applicant: Sarvajit Chakravarty ,  Barry Patrick Hart ,  Rajendra Parasmal Jain

Inventor： Sarvajit Chakravarty ,  Barry Patrick Hart ,  Rajendra Parasmal Jain

IPC: C07D471/04 ,  C07D471/18 ,  C07D471/14 ,  C07D471/22

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D471/18 ,  C07D471/22

Abstract: This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

公开(公告)号：US20120184580A1

公开(公告)日：2012-07-19

申请号：US13263728

申请日：2010-04-09

Applicant: Sarvajit Chakravarty ,  Rajendra Parasmal Jain

Inventor： Sarvajit Chakravarty ,  Rajendra Parasmal Jain

IPC: A61K31/4166 ,  A61P35/00 ,  C07D401/10 ,  A61K31/454 ,  C07D233/86 ,  C07D403/10

CPC classification number: C07D233/76 ,  C07D233/86

Abstract: Substituted di-arylhydantoin and di-arylthiohydantoins are provided and may find use as androgen receptor modulators. The compounds may find particular use in treating prostate cancer, including CRPC and/or hormone-sensitive prostate cancer.

Abstract translation: 提供了取代的二芳基乙内酰脲和二芳基硫代乙内酰脲，可以用作雄激素受体调节剂。 这些化合物可以特别用于治疗前列腺癌，包括CRPC和/或激素敏感性前列腺癌。

公开(公告)号：US20120172377A1

公开(公告)日：2012-07-05

申请号：US13318124

申请日：2010-04-29

Applicant: Rajendra Parasmal Jain ,  Sarvajit Chakravarty

Inventor： Rajendra Parasmal Jain ,  Sarvajit Chakravarty

IPC: A61K31/437 ,  A61P25/00 ,  A61P25/28 ,  C07D471/04 ,  A61K31/506

CPC classification number: C07D471/04

Abstract: New heterocyclic compounds that may be used to modulate a histamine receptor in an individual are described. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Abstract translation: 描述了可用于调节个体中组胺受体的新杂环化合物。 描述了吡啶并[4,3-b]吲哚，以及包含化合物的药物组合物以及在各种治疗应用中使用该化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或 神经元紊乱。

公开(公告)号：US20120136008A1

公开(公告)日：2012-05-31

申请号：US13318123

申请日：2010-04-29

Applicant: Rajendra Parasmal Jain ,  Sarvajit Chakravarty

Inventor： Rajendra Parasmal Jain ,  Sarvajit Chakravarty

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/501 ,  A61P25/28 ,  C07D471/04 ,  A61K31/506

CPC classification number: C07D471/04

Abstract: New heterocyclic compounds that may be used to modulate a histamine receptor in an individual are described. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

公开(公告)号：US20130331421A1

公开(公告)日：2013-12-12

申请号：US13925507

申请日：2013-06-24

Applicant: Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

Inventor： Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

IPC: C07D233/86 ,  C07D233/72

CPC classification number: C07D233/86 ,  A61K31/4166 ,  C07D233/72 ,  C07D233/74 ,  C07D233/84

Abstract: Compositions, such as pharmaceutical compositions, comprising specific diarylhydantoin and diarylthiohydantoin compounds, or salts or solvates thereof, are provided. Isolated and purified forms of the compounds are also described, as are unit dosage forms, compositions of substantially pure compound and kits comprising the compounds. The compounds and pharmaceutical compositions thereof may find use in the prevention and/or treatment of a variety of conditions, including prostate cancer, Parkinson's disease, Alzheimer's disease, and others.

Abstract translation: 提供了包含特定的二芳基乙内酰脲和二芳基硫代乙内酰脲化合物的组合物，例如药物组合物，或其盐或溶剂合物。 还描述了分离和纯化形式的化合物，单位剂型，基本上纯的化合物的组合物和包含该化合物的试剂盒也是如此。 其化合物及其药物组合物可用于预防和/或治疗各种病症，包括前列腺癌，帕金森病，阿尔茨海默病等。

公开(公告)号：US20120035231A1

公开(公告)日：2012-02-09

申请号：US13202970

申请日：2010-02-24

Applicant: Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

Inventor： Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

IPC: A61K31/4166 ,  A61P25/16 ,  A61P35/00 ,  A61P25/28 ,  C07D233/72 ,  C07D233/86

CPC classification number: C07D233/86 ,  A61K31/4166 ,  C07D233/72 ,  C07D233/74 ,  C07D233/84

Abstract: Compositions, such as pharmaceutical compositions, comprising specific diarylhydantoin and diarylthiohydantoin compounds, or salts or solvates thereof, are provided. Isolated and purified forms of the compounds are also described, as are unit dosage forms, compositions of substantially pure compound and kits comprising the compounds. The compounds and pharmaceutical compositions thereof may find use in the prevention and/or treatment of a variety of conditions, including prostate cancer, Parkinson's disease, Alzheimer's disease, and others.

Abstract translation: 提供了包含特定的二芳基乙内酰脲和二芳基硫代乙内酰脲化合物的组合物，例如药物组合物，或其盐或溶剂合物。 还描述了分离和纯化形式的化合物，单位剂型，基本上纯的化合物的组合物和包含该化合物的试剂盒也是如此。 其化合物及其药物组合物可用于预防和/或治疗各种病症，包括前列腺癌，帕金森病，阿尔茨海默病等。

公开(公告)号：US09023879B2

公开(公告)日：2015-05-05

申请号：US13925507

申请日：2013-06-24

Applicant: Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

Inventor： Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

IPC: A61K31/4166 ,  C07D233/72 ,  C07D233/86 ,  C07D233/74 ,  C07D233/84

CPC classification number: C07D233/86 ,  A61K31/4166 ,  C07D233/72 ,  C07D233/74 ,  C07D233/84

Abstract: Compositions, such as pharmaceutical compositions, comprising specific diarylhydantoin and diarylthiohydantoin compounds, or salts or solvates thereof, are provided. Isolated and purified forms of the compounds are also described, as are unit dosage forms, compositions of substantially pure compound and kits comprising the compounds. The compounds and pharmaceutical compositions thereof may find use in the prevention and/or treatment of a variety of conditions, including prostate cancer, Parkinson's disease, Alzheimer's disease, and others.

Abstract translation: 提供了包含特定的二芳基乙内酰脲和二芳基硫代乙内酰脲化合物的组合物，例如药物组合物，或其盐或溶剂合物。 还描述了分离和纯化形式的化合物，单位剂型，基本上纯的化合物的组合物和包含该化合物的试剂盒也是如此。 其化合物及其药物组合物可用于预防和/或治疗各种病症，包括前列腺癌，帕金森病，阿尔茨海默病等。

公开(公告)号：US08524755B2

公开(公告)日：2013-09-03

申请号：US13202970

申请日：2010-02-24

Applicant: Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

Inventor： Rajendra Parasmal Jain ,  Jacqueline A. Gibbons

IPC: A61K31/4166 ,  C07D233/72

CPC classification number: C07D233/86 ,  A61K31/4166 ,  C07D233/72 ,  C07D233/74 ,  C07D233/84

Abstract: Compositions, such as pharmaceutical compositions, comprising specific diarylhydantoin and diarylthiohydantoin compounds, or salts or solvates thereof, are provided. Isolated and purified forms of the compounds are also described, as are unit dosage forms, compositions of substantially pure compound and kits comprising the compounds. The compounds and pharmaceutical compositions thereof may find use in the prevention and/or treatment of a variety of conditions, including prostate cancer, Parkinson's disease, Alzheimer's disease, and others.

公开(公告)号：US20100099667A1

公开(公告)日：2010-04-22

申请号：US12410425

申请日：2009-03-24

Applicant: David T. Hung ,  Andrew Asher Protter ,  Sarjavit Chakravarty ,  Rajendra Parasmal Jain

Inventor： David T. Hung ,  Andrew Asher Protter ,  Sarjavit Chakravarty ,  Rajendra Parasmal Jain

IPC: A61K31/541 ,  C07D471/08 ,  C07D279/12 ,  C07D413/14 ,  A61K31/439 ,  A61K31/5377 ,  A61P25/18 ,  A61P25/28

CPC classification number: C07D451/00 ,  C07D471/08 ,  C07D471/18

Abstract: This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Abstract translation: 本公开涉及可用于调节个体中组胺受体的新化合物。 描述了新的化合物，包括新的桥连杂环[4,3-b]吲哚化合物。 还提供药物组合物。 还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

公开(公告)号：US09174943B2

公开(公告)日：2015-11-03

申请号：US13785504

申请日：2013-03-05

Applicant: Rajendra Parasmal Jain ,  Remy Angelaud ,  Andrew Thompson ,  Carol Lamberson ,  Scott Greenfield

Inventor： Rajendra Parasmal Jain ,  Remy Angelaud ,  Andrew Thompson ,  Carol Lamberson ,  Scott Greenfield

IPC: C07D233/86 ,  C07D235/02 ,  C07D233/40 ,  C07D233/42

CPC classification number: C07D233/86 ,  C07C231/12 ,  C07C237/30 ,  C07D235/02

Abstract: Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

Abstract translation: 提供了二芳基硫代乙内酰脲和二芳基乙内酰脲化合物的合成方法。 含有该药物的药物在治疗前列腺癌方面特别有用，包​​括抗阉割前列腺癌和/或激素敏感性前列腺癌。