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公开(公告)号：US08242138B2
公开(公告)日：2012-08-14
申请号：US13204302
申请日：2011-08-05
Applicant: YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu
Inventor： YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu
IPC: A01N43/40 , A61K31/445 , C07D405/00
CPC classification number: C07D295/195 , C07D207/12 , C07D211/58 , C07D409/12
Abstract: The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, where R1-3, R5, R7, a, b, Q, X, X′, X″, Y, Z, and Ar are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also relates to pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中R1-3，R5，R7，a，b，Q，X，X'，X“，Y，Z和Ar如 规范。 这些化合物是毒蕈碱受体拮抗剂。 本发明还涉及含有这种化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺病的方法。
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Patent Agency Ranking
公开(公告)号：US20110201583A1
公开(公告)日：2011-08-18
申请号：US13096651
申请日：2011-04-28
Applicant: YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
Inventor： YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
IPC: A61K31/56 , C07D405/12 , C07D207/36 , C07D211/44 , C07D401/12 , A61K31/497 , A61K31/445 , A61K31/40 , A61P11/08
CPC classification number: C07D333/24 , C07D209/14 , C07D213/38 , C07D231/12 , C07D277/28 , C07D295/13 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/58
Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
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33.发明授权Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists 有权可用作毒蕈碱受体拮抗剂的季铵二苯基甲基化合物公开(公告)号：US07834185B2
公开(公告)日：2010-11-16
申请号：US12070780
申请日：2008-02-21
Applicant: YuHua Ji , Craig Husfeld , Christopher Lange , Rick Lee , YongQi Mu
Inventor： YuHua Ji , Craig Husfeld , Christopher Lange , Rick Lee , YongQi Mu
IPC: C07D211/70 , C07D207/08
CPC classification number: C07D207/09 , C07D207/08 , C07D207/48
Abstract: The invention provides compounds of formula I: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a-e and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明提供式I化合物：盐或两性离子形式或其药学上可接受的盐，其中R1-6，a-e和Q如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。
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34.发明授权公开(公告)号：US07597190B2
公开(公告)日：2009-10-06
申请号：US10966906
申请日：2004-10-15
Applicant: Rick Lee
Inventor： Rick Lee
Abstract: The invention is related to induction driven straight or curved conveyors. Belts of the current invention have a flexible strip of permanent rare earth magnetic composition embedded therein. In combination with the flexible strip, stators induce magnetic flux to advance the conveyor belt.
Abstract translation: 本发明涉及感应驱动的直线或弯曲输送机。 本发明的带具有嵌入其中的永久性稀土磁性组合物的柔性带。 与柔性条组合，定子诱导磁通量推进传送带。
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公开(公告)号：US20060081446A1
公开(公告)日：2006-04-20
申请号：US10966906
申请日：2004-10-15
Applicant: Rick Lee
Inventor： Rick Lee
IPC: B65G15/02
Abstract: The invention is related to induction driven straight or curved conveyors. Belts of the current invention have a flexible strip of permanent rare earth magnetic composition embedded therein. In combination with the flexible strip, stators induce magnetic flux to advance the conveyor belt.
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