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1.发明授权Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists 有权可用作毒蕈碱受体拮抗剂的季铵二苯基甲基化合物公开(公告)号：US08802856B2
公开(公告)日：2014-08-12
申请号：US14059755
申请日：2013-10-22
Applicant: YuHua Ji , Craig Husfeld , Christopher Lange , Rick Lee , YongQi Mu
Inventor： YuHua Ji , Craig Husfeld , Christopher Lange , Rick Lee , YongQi Mu
IPC: C07D207/08 , C07D211/70 , C07D207/09 , C07D207/48
CPC classification number: C07D207/09 , C07D207/08 , C07D207/48
Abstract: The invention provides compounds of formula I: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a-e and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明提供式I化合物：盐或两性离子形式或其药学上可接受的盐，其中R1-6，a-e和Q如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。
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公开(公告)号：US08017617B2
公开(公告)日：2011-09-13
申请号：US12333628
申请日：2008-12-12
Applicant: YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu
Inventor： YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu
IPC: A61K31/497 , C07D241/04 , C07D295/00 , C07D405/00
CPC classification number: C07D295/195 , C07D207/12 , C07D211/58 , C07D409/12
Abstract: The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, where R1-3, R5, R7, a, b, Q, X, X′, X″, Y, Z, and Ar are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also relates to pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中R1-3，R5，R7，a，b，Q，X，X'，X“，Y，Z和Ar如 规范。 这些化合物是毒蕈碱受体拮抗剂。 本发明还涉及含有这种化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺病的方法。
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3.发明申请AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 有权含有AMIDINE的化合物作为MUSCARINIC受体拮抗剂有用公开(公告)号：US20090170870A1
公开(公告)日：2009-07-02
申请号：US12333628
申请日：2008-12-12
Applicant: YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu , Cameron Smith
Inventor： YuHua Ji , Craig Husfeld , Rick Lee , YongQi Mu , Cameron Smith
IPC: A61K31/495 , C07D295/125 , C07D211/58 , C07D405/06 , A61K31/496 , A61K31/4015 , A61P11/00 , A61K31/4535 , A61K31/4468 , C07D409/06 , C07D207/12
CPC classification number: C07D295/195 , C07D207/12 , C07D211/58 , C07D409/12
Abstract: The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, where R1-3, R5, R7, a, b, Q, X, X′, X″, Y, Z, and Ar are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also relates to pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中R1-3，R5，R7，a，b，Q，X，X'，X“，Y，Z和Ar定义如 规格。 这些化合物是毒蕈碱受体拮抗剂。 本发明还涉及含有这种化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺病的方法。
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4.发明授权Interlocker for a conveyor belt and method of utilizing an interlocker for a conveyor belt 有权用于传送带的联锁器和利用传送带的联锁器的方法公开(公告)号：US07131530B2
公开(公告)日：2006-11-07
申请号：US11044412
申请日：2005-01-27
Applicant: Rick Lee , Stephen D. Duncan
Inventor： Rick Lee , Stephen D. Duncan
IPC: B65G21/16
Abstract: The invention is related to drive units for conveyor belts. A flexible rider connected to the belt includes a gear for meshing with a gear of the rotable driver. The meshing of the gears allows the conveyor belt to be pulled about the conveyor.
Abstract translation: 本发明涉及传送带的驱动装置。 连接到皮带的柔性骑手包括与可旋转驾驶员的齿轮啮合的齿轮。 齿轮啮合允许传送带围绕输送机拉动。
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5.发明申请公开(公告)号：US20060163040A1
公开(公告)日：2006-07-27
申请号：US11044412
申请日：2005-01-27
Applicant: Rick Lee , Stephen Duncan
Inventor： Rick Lee , Stephen Duncan
IPC: B65G15/02
Abstract: The invention is related to drive units for conveyor belts. A flexible rider connected to the belt includes a gear for meshing with a gear of the rotable driver. The meshing of the gears allows the conveyor belt to be pulled about the conveyor.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20130281489A1
公开(公告)日：2013-10-24
申请号：US13921396
申请日：2013-06-19
Applicant: Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
Inventor： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
IPC: C07D405/06
CPC classification number: C07D409/14 , C07D205/04 , C07D211/26 , C07D211/58 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12
Abstract: The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明提供下式的化合物：盐或两性离子形式或其药学上可接受的盐，其中R1-6，a，Z和Q如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。
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7.发明授权公开(公告)号：US08202891B2
公开(公告)日：2012-06-19
申请号：US12148887
申请日：2008-04-23
Applicant: Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
Inventor： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
IPC: A61K31/4468 , C07D211/58
CPC classification number: C07D409/14 , C07D205/04 , C07D211/26 , C07D211/58 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12
Abstract: The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明提供下式的化合物：盐或两性离子形式或其药学上可接受的盐，其中R1-6，a，Z和Q如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。
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公开(公告)号：US08039489B2
公开(公告)日：2011-10-18
申请号：US13096651
申请日：2011-04-28
Applicant: YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
Inventor： YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
IPC: A61K31/4439 , A61K31/4025 , A61K31/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D207/12
CPC classification number: C07D333/24 , C07D209/14 , C07D213/38 , C07D231/12 , C07D277/28 , C07D295/13 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/58
Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
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9.发明授权公开(公告)号：US07960385B2
公开(公告)日：2011-06-14
申请号：US12231861
申请日：2008-09-05
Applicant: YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
Inventor： YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
IPC: A61K31/496 , C07D209/14 , C07D213/38 , C07D231/12 , C07D277/28 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/58 , C07D295/13
CPC classification number: C07D333/24 , C07D209/14 , C07D213/38 , C07D231/12 , C07D277/28 , C07D295/13 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/58
Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中R1-3，R5-7，a，X，Y，Y'，Y“和Z如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。
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