公开(公告)号：US20100021438A1

公开(公告)日：2010-01-28

申请号：US12435084

申请日：2009-05-04

申请人： Mark E. Rosenberg ,  Sandeep Gupta

发明人： Mark E. Rosenberg ,  Sandeep Gupta

IPC分类号： A61K35/12 ,  C12N5/07 ,  C12N5/10 ,  A61P35/00 ,  C12Q1/68

CPC分类号： C12N5/0686 ,  A61K35/12 ,  C12N5/0607 ,  C12N2500/25 ,  C12N2500/42 ,  C12N2501/11 ,  C12N2501/135 ,  C12N2501/235 ,  C12N2501/39 ,  C12N2533/52

摘要： The invention relates generally to methods for isolation and culture of kidney stem cells, cells isolated by the methods, and therapeutic uses for those cells.

摘要翻译： 本发明一般涉及用于分离和培养肾干细胞的方法，通过该方法分离的细胞，以及这些细胞的治疗用途。

公开(公告)号：US20090181975A1

公开(公告)日：2009-07-16

申请号：US12353443

申请日：2009-01-14

申请人： Inigo Saenz de Tejada ,  Javier Angulo ,  Sandeep Gupta

发明人： Inigo Saenz de Tejada ,  Javier Angulo ,  Sandeep Gupta

IPC分类号： A61K31/4985 ,  A61K31/352 ,  A61P15/12 ,  A61P15/10 ,  A61K31/519

CPC分类号： A61K31/352 ,  A61K31/4985 ,  A61K31/519

摘要： The present invention provides methods of treating sexual dysfunction. The methods include administering an effective amount of nebivolol, or a pharmaceutically acceptable salt thereof, alone or in combination with a second active agent e.g. a PDE-5 inhibitor, such as sildenafil citrate. The methods of the present invention are particularly suited to the treatment of erectile dysfunction and female sexual arousal disorder.

摘要翻译： 本发明提供治疗性功能障碍的方法。 所述方法包括单独或与第二活性剂组合施用有效量的奈必洛尔或其药学上可接受的盐，例如， PDE-5抑制剂，如西地那非柠檬酸盐。 本发明的方法特别适用于治疗勃起功能障碍和女性性唤醒障碍。

公开(公告)号：US20090112753A1

公开(公告)日：2009-04-30

申请号：US12257442

申请日：2008-10-24

申请人： Sandeep Gupta ,  Christian Hall ,  James Reid ,  Shen Lu ,  Dennis Horton ,  Lee Grice ,  Thresa Dixon ,  Scott Garten ,  Sudhakar Reddy

发明人： Sandeep Gupta ,  Christian Hall ,  James Reid ,  Shen Lu ,  Dennis Horton ,  Lee Grice ,  Thresa Dixon ,  Scott Garten ,  Sudhakar Reddy

IPC分类号： G06Q40/00

CPC分类号： G06N99/005 ,  G06Q20/10 ,  G06Q40/00 ,  G06Q40/02 ,  G06Q40/025

摘要： The present invention relates to application processing and decisioning systems and processes. One embodiment of the invention includes a method for automating decisioning for a credit request associated with an applicant. The method includes providing a user computer interface adapted to receive information associated with an applicant, and further adapted to display and receive information associated with at least one decision rule. The method also includes receiving information associated with an applicant through the user computer interface; receiving information associated with the applicant from at least one data source; and receiving a selection of information associated with a plurality of decision rules through the user computer interface. Furthermore, the method includes receiving a selection of rule flow information associated with the plurality of decision rules through the user computer interface; generating a plurality of decision rules based at least in part on the information associated with the applicant, based at least in part on the information associated with the applicant from at least one data source, and based at least in part on the selection of information associated with a plurality of decision rules, wherein an outcome associated with the at least one decision rule can be obtained; and based in part on at least the rule flow information, displaying at least a portion of the plurality of decision rules through the user computer interface.

摘要翻译： 本发明涉及应用处理和决策系统和过程。 本发明的一个实施例包括一种用于自动决定与申请人相关联的信用请求的方法。 该方法包括提供适于接收与申请人相关联的信息的用户计算机接口，并且还适于显示和接收与至少一个决策规则相关的信息。 该方法还包括通过用户计算机接口接收与申请人相关联的信息; 从至少一个数据源接收与申请人相关联的信息; 以及通过所述用户计算机接口接收与多个决策规则相关联的信息的选择。 此外，该方法包括通过用户计算机接口接收与多个决策规则相关联的规则流信息的选择; 至少部分地至少部分地基于与申请人相关联的信息从至少一个数据源生成多个决定规则，至少部分地基于与申请人相关联的信息，并且至少部分地基于与相关联的信息的选择 具有多个决策规则，其中可以获得与所述至少一个决策规则相关联的结果; 并且至少部分地基于规则流信息，通过用户计算机接口显示多个决策规则的至少一部分。

公开(公告)号：US20090048999A1

公开(公告)日：2009-02-19

申请号：US12257453

申请日：2008-10-24

申请人： Sandeep Gupta ,  Christian Hall ,  James Reid ,  Shen Lu ,  Dennis Horton ,  Lee Grice ,  Thresa Dixon ,  Scott Garten ,  Sudhakar Reddy

发明人： Sandeep Gupta ,  Christian Hall ,  James Reid ,  Shen Lu ,  Dennis Horton ,  Lee Grice ,  Thresa Dixon ,  Scott Garten ,  Sudhakar Reddy

IPC分类号： G06N5/04 ,  G06Q40/00

CPC分类号： G06Q40/025 ,  G06N20/00 ,  G06Q20/10 ,  G06Q40/00 ,  G06Q40/02

摘要： The present invention relates to application processing and decisioning systems and processes. One embodiment of the invention includes a method for automating decisioning for a credit request associated with an applicant. The method includes providing a user computer interface adapted to receive information associated with an applicant, and further adapted to display and receive information associated with at least one decision rule. The method also includes receiving information associated with an applicant through the user computer interface; receiving information associated with the applicant from at least one data source; and receiving a selection of information associated with a plurality of decision rules through the user computer interface. Furthermore, the method includes receiving a selection of rule flow information associated with the plurality of decision rules through the user computer interface; generating a plurality of decision rules based at least in part on the information associated with the applicant, based at least in part on the information associated with the applicant from at least one data source, and based at least in part on the selection of information associated with a plurality of decision rules, wherein an outcome associated with the at least one decision rule can be obtained; and based in part on at least the rule flow information, displaying at least a portion of the plurality of decision rules through the user computer interface.

公开(公告)号：US07356027B1

公开(公告)日：2008-04-08

申请号：US10264971

申请日：2002-10-04

申请人： Pankaj Parekh ,  Sandeep Gupta ,  Vijay Mamtani ,  Himanshu Deoskar

发明人： Pankaj Parekh ,  Sandeep Gupta ,  Vijay Mamtani ,  Himanshu Deoskar

IPC分类号： H04L12/28 ,  H04L12/56

CPC分类号： H04L65/605 ,  H04L67/00 ,  H04L69/22 ,  H04L69/32

摘要： The present invention essentially comprises a Packet Receiver and a Stream Manager for a computer network. When a stream of packets passes through the present invention, they are received by the Packet Receiver. The Packet Receiver identifies the session to which the packet stream belongs, and passes the packet to the Stream Manager. The Stream Manager identifies the application generating the packet stream by scanning an Application ID Hash Table, which is a table that contains a mapping of destination ports to corresponding applications. Thereafter, it uses a State Machine Execution Engine to execute application decode instructions on the packet stream. The application decode instructions are stored in a table called Expression Action Table, and are generated based on a decode script created by the user for each application. The application decode instructions are chosen by the State Machine Execution Engine based on the current state of an Application Decode State Machine, which is a state machine that keeps track of the application decode process. The results of the State Machine Execution Engine are passed to the Stream Manager, and are stored in tables called Session Cache Table and Application Instance Table. Once the Stream Manager has decoded all the transactions and parameters of the application, the decoded information is sent with the packets in the packet stream.

摘要翻译： 本发明基本上包括用于计算机网络的分组接收器和流管理器。 当分组流通过本发明时，它们被分组接收机接收。 分组接收者识别分组流所属的会话，并将分组传递给流管理器。 流管理器通过扫描应用程序ID哈希表来识别生成分组流的应用程序，该表是包含目标端口映射到相应应用程序的表。 此后，它使用状态机执行引擎在分组流上执行应用解码指令。 应用解码指令存储在称为表达式动作表的表中，并且基于由用户为每个应用创建的解码脚本生成。 应用解码指令由状态机执行引擎基于应用程序解码状态机的当前状态来选择，应用程序解码状态机是跟踪应用程序解码过程的状态机。 状态机执行引擎的结果被传递给流管理器，并存储在称为会话缓存表和应用程序实例表的表中。 一旦流管理器解码了应用程序的所有事务和参数，解码的信息就与分组流中的数据包一起发送。

公开(公告)号：US07321556B1

公开(公告)日：2008-01-22

申请号：US10281809

申请日：2002-10-28

申请人： Pankaj Parekh ,  Sandeep Gupta ,  Vijay Mamtani

发明人： Pankaj Parekh ,  Sandeep Gupta ,  Vijay Mamtani

IPC分类号： H04J3/14

CPC分类号： H04L47/10 ,  H04L47/20 ,  H04L47/2425 ,  H04L47/27 ,  H04L47/29 ,  H04L47/323

摘要： A system and method for enforcing policies on data packets in a computer network is disclosed. The enforcement of policies is done by prioritizing and regulating the flow of data packets. The regulation of prioritized data packets includes a determination of: service level agreement violations, flow control of data packets of a predefined priority and session resettings. For determination of service level agreements the policy engine carries out a response time calculation and finds if it is in consonance with the response time agreed upon in the service level agreement. Flow control in case of a service level agreement violation is implemented either by reducing the server side window size or by delaying acknowledgement packets sent by the client.

摘要翻译： 公开了一种用于在计算机网络中对数据分组执行策略的系统和方法。 策略的执行是通过对数据包的流量进行优先级排序来实现的。 对优先化数据分组的调节包括确定：服务级别协议违反，预定义优先级的数据分组的流量控制和会话重置。 为了确定服务水平协议，策略引擎执行响应时间计算，并确定是否符合服务级别协议中商定的响应时间。 通过减少服务器端窗口大小或通过延迟客户端发送的确认数据包来实现服务级别协议违规情况下的流量控制。

公开(公告)号：US20070188232A1

公开(公告)日：2007-08-16

申请号：US11783601

申请日：2007-04-10

申请人： Sandeep Gupta ,  Venugopal Gopinathan

发明人： Sandeep Gupta ,  Venugopal Gopinathan

IPC分类号： H03F3/45

CPC分类号： H03F1/52 ,  H03F1/523 ,  H03F3/45085 ,  H03F3/45183 ,  H03F2200/447 ,  H03F2203/45288 ,  H03F2203/45292 ,  H03F2203/45324 ,  H03F2203/45336 ,  H03F2203/45398 ,  H03F2203/45696 ,  H03F2203/45722

摘要： A CMOS gain stage includes biasing circuitry configured to insure saturation of a subsequent stage without a source follower circuit. The CMOS gain stage is optionally powered by a supply voltage that is greater than a permitted supply voltage for a processes technology that is used to fabricate the CMOS gain stage. In order to protect CMOS devices within the CMOS gain stage, optional drain-to-bulk junction punch-through protection circuitry is disclosed. A variety of optional features can be implemented alone and/or in various combinations of one another. Optional features include process-voltage-temperature (“PVT”) variation protection circuitry, which renders a gain relatively independent of process, voltage, and/or temperature variations. Optional features further include bandwidth enhancement circuitry.

公开(公告)号：US07257833B1

公开(公告)日：2007-08-14

申请号：US10052745

申请日：2002-01-17

申请人： Pankaj S. Parekh ,  Vimal Vaidya ,  Sandeep Gupta ,  Pranav Shah

发明人： Pankaj S. Parekh ,  Vimal Vaidya ,  Sandeep Gupta ,  Pranav Shah

IPC分类号： H04L9/00

CPC分类号： H04L63/0227 ,  H04L63/102

摘要： Enforcing a plurality of different policies on a stream of packets is disclosed. In lieu of running separate algorithms for each policy, the system exploits the commonalities of all of the policies. The conditions corresponding to the compiled rules are arranged in a condition tree and processed in a pipelined architecture that allows the results of the various stages to be carried forward into subsequent stages of processing. The rules for which all conditions have been satisfied can be identified by one stage of processing in one pass of condition tree traversal and are passed to subsequent stages. A rule table corresponding to an individual policy type can then be readily examined to determine partial or complete satisfaction of the rule of that policy type, without requiring a re-examination of the conditions underlying the rule. Additionally, corresponding actions can be taken where rule satisfaction is determined. This approach allows extremely high-speed policy enforcement performance.

摘要翻译： 公开了在分组流上执行多个不同的策略。 代替为每个策略运行单独的算法，系统利用了所有策略的共同点。 与编译规则相对应的条件被布置在条件树中，并且以流水线架构进行处理，其允许将各个阶段的结果转移到后续的处理阶段。 所有条件已经满足的规则可以通过条件树遍历的一遍中的一个处理阶段来识别，并被传递到后续阶段。 然后可以容易地检查对应于单个策略类型的规则表，以确定该策略类型的规则的部分或完全满足，而不需要重新检查规则的基础。 另外，在确定规则满足的情况下可以采取相应的动作。 这种方法允许极高的策略执行性能。

公开(公告)号：US07219142B1

公开(公告)日：2007-05-15

申请号：US10277197

申请日：2002-10-21

申请人： Pankaj Parekh ,  Sandeep Gupta ,  Vijay Mamtani ,  Atul Jain ,  Sanjay K. Aggarwal

发明人： Pankaj Parekh ,  Sandeep Gupta ,  Vijay Mamtani ,  Atul Jain ,  Sanjay K. Aggarwal

IPC分类号： G06F15/16

CPC分类号： H04L41/0893 ,  H04L41/5048 ,  H04L63/20

摘要： The present invention is a system and method for allowing an administrator of a computer network higher up in a hierarchical arrangement to define the scope of policies for the services offered, and users lower in the hierarchical arrangement to customize policies within the scope defined by the administrator. While defining policy rules, administrators classify them as scoping or non-scoping. Users lower in the hierarchical arrangement can then customize scoping rules by defining sub-rules. Policy rules have a condition part and an action part, and the sub-rules can be used to change the scope of the condition and action parts. The present invention adds all the non-scoping policy rules, all the scoping policy rules, and all the sub-rules (with their scope limited by the scoping rules) to a rules database. This rules database is then used by any policy enforcement engine to enforce policy rules.

摘要翻译： 本发明是一种系统和方法，用于允许计算机网络的管理员以分层布置更高的位置来定义所提供的服务的策略的范围，并且分层布置中的用户较低以定制由管理员定义的范围内的策略 。 在定义策略规则的同时，管理员将其分类为范围或非范围。 然后可以通过定义子规则来定制分层布置中的用户，定义范围规则。 策略规则具有条件部分和动作部分，子规则可用于更改条件和动作部分的范围。 本发明将所有非范围规则策略规则，所有范围规则策略规则以及所有子规则（其范围受范围规则限制）添加到规则数据库。 然后，此规则数据库将被任何策略执行引擎用于实施策略规则。

公开(公告)号：US20070082920A1

公开(公告)日：2007-04-12

申请号：US11244614

申请日：2005-10-06

申请人： Yongsheng Song ,  Yongchun Hou ,  Sandeep Gupta ,  Aimee Reed ,  Debasis Ghosh

发明人： Yongsheng Song ,  Yongchun Hou ,  Sandeep Gupta ,  Aimee Reed ,  Debasis Ghosh

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D487/02

摘要： Disclosed herein are pyrido[2,3-d]pyrimidines having the structure wherein R1, and R2 are independently selected from nitro and amino; wherein R3 is selected from alkyl (C1-C10) and cycloalkyl (C3-C8); wherein R4 is selected from hydrogen, benzyl, alkyl (C1-C10), cycloalkyl (C3-C8), arylalkyl (C4-C8), and aryl (C3-C8); wherein R5 and R6 are independently selected from hydrogen, benzyl, alkyl (C1-C10), cycloalkyl (C3-C8), arylalkyl (C4-C14), and aryl (C3-C8); wherein R3 and R4 may form a ring; wherein R5 and R6 may form a ring or a heterocyclic structure; and wherein R5 and R6 are independently unsubstituted or substituted, wherein each substituent is independently selected from halogen, amino, alkyl (C1-C6), haloalkyl (C1-C6), alkoxy(C1-C6), alkylenedioxy, aryl, heteroaryl, and cycloalkyl (C3-C8). Also disclosed are methods for the preparation of compounds of Formula I and various intermediates. These compounds are useful as NAD+-dependent DNA ligase inhibitors.

摘要翻译： 本文公开了具有其中R 1，R 2和R 2独立地选自硝基和氨基的结构的吡啶并[2,3-d]嘧啶; 其中R 3选自烷基（C 1 -C 10）和环烷基（C 3 -C 8）; 其中R 4选自氢，苄基，烷基（C1-C10），环烷基（C3-C8），芳基烷基（C4-C8）和芳基（C3-C8）; 其中R 5和R 6独立地选自氢，苄基，烷基（C1-C10），环烷基（C3-C8），芳基烷基（C4-C14）和 芳基（C3-C8）; 其中R 3和R 4可以形成环; 其中R 5和R 6可以形成环或杂环结构; 并且其中R 5和R 6独立地是未取代的或取代的，其中每个取代基独立地选自卤素，氨基，烷基（C 1 -C 6），卤代烷基（C 1 -C 6 ），烷氧基（C1-C6），亚烷基二氧基，芳基，杂芳基和环烷基（C3-C8）。 还公开了制备式I化合物和各种中间体的方法。 这些化合物可用作NAD +依赖性DNA连接酶抑制剂。