公开(公告)号：US20090306988A1

公开(公告)日：2009-12-10

申请号：US12135131

申请日：2008-06-06

申请人： Francine Chen ,  John Adcock

发明人： Francine Chen ,  John Adcock

IPC分类号： G10L13/00

CPC分类号： H04K1/06 ,  G10L21/0364 ,  G10L25/93 ,  H04K1/04

摘要： An audio privacy system reduces the intelligibility of speech in an audio signal while preserving prosodic information, such as pitch, relative energy and intonation so that a listener has the ability to recognize environmental sounds but not the speech itself. An audio signal is processed to separate non-vocalic information, such as pitch and relative energy of speech, from vocalic regions, after which syllables are identified within the vocalic regions. Representations of the vocalic regions are computed to produce a vocal tract transfer function and an excitation. The vocal tract transfer function for each syllable is then replaced with the vocal tract transfer function from another prerecorded vocalic sound. In one aspect, the identity of the replacement vocalic sound is independent of the identity of the syllable being replaced. A modified audio signal is then synthesized with the original prosodic information and the modified vocal tract transfer function to produce unintelligible speech that preserves the pitch and energy of the speech as well as environmental sounds.

摘要翻译： 音频隐私系统降低音频信号中的语音的可懂度，同时保留诸如音调，相对能量和语调之类的韵律信息，以便收听者具有识别环境声音而不是语音本身的能力。 处理音频信号以从声乐区域分离非声音信息，例如语音的音调和相对能量，之后在声音区域内识别音节。 计算声乐区域的表示以产生声道传递函数和激发。 然后，每个音节的声道传递功能由另一预先录制的声乐中的声道传递功能所取代。 在一个方面，替换的声音的身份与被替换的音节的身份无关。 然后，将经修改的音频信号与原始韵律信息和修改的声道传递函数合成以产生保持语音的音调和能量以及环境声音的无法理解的语音。

公开(公告)号：US20060293506A1

公开(公告)日：2006-12-28

申请号：US11109181

申请日：2005-04-18

申请人： Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng ,  Xiao-dong Yang ,  Francine Chen ,  Gadi Gazit ,  Richard Weber ,  Binyam Bezabeh

发明人： Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng ,  Xiao-dong Yang ,  Francine Chen ,  Gadi Gazit ,  Richard Weber ,  Binyam Bezabeh

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  C07K2317/21 ,  C07K2317/56

摘要： The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

公开(公告)号：US20060171884A1

公开(公告)日：2006-08-03

申请号：US11303608

申请日：2005-12-16

申请人： Ian Foltz ,  Chadwick King ,  Peter Ling ,  Jaspal Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Scatena ,  Bruce Keyt ,  Edwin Madison ,  Wayne Godfrey ,  Stanislaw Morkowski ,  Jennifer Richardson

发明人： Ian Foltz ,  Chadwick King ,  Peter Ling ,  Jaspal Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Scatena ,  Bruce Keyt ,  Edwin Madison ,  Wayne Godfrey ,  Stanislaw Morkowski ,  Jennifer Richardson

IPC分类号： A61K51/00 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C12N5/06

CPC分类号： C07K16/40 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2500/04

摘要： Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.

公开(公告)号：US20050144064A1

公开(公告)日：2005-06-30

申请号：US10741336

申请日：2003-12-19

申请人： Hermann Calabria ,  Francine Chen ,  Ayman Farahat ,  Daniel Greene

发明人： Hermann Calabria ,  Francine Chen ,  Ayman Farahat ,  Daniel Greene

IPC分类号： G06Q30/00 ,  G06F17/60

CPC分类号： G06Q30/02 ,  G06Q30/0275 ,  G06Q30/08 ,  G06Q40/04

摘要： A method of generating a bid for an advertiser for placement of an advertisement in association with a search results list, where the search results list is generated in response to a search query, is provided. In one embodiment, the method includes: a) associating the at least one keyword with the bid, wherein the search query is associated with the at least one keyword, and b) determining an amount of the bid, associated with the at least one keyword, for placement of the advertisement in association with the search results list generated in response to the search query associated with the at least one keyword. The bid is determined based at least in part on bids by other advertisers in competition with the first advertiser for placement of other advertisements with an expectation that the determined bid may elicit a desired change in the bids by the other advertisers.

摘要翻译： 提供了一种生成针对广告商的出价的方法，用于与搜索结果列表相关联地放置广告，其中响应于搜索查询生成搜索结果列表。 在一个实施例中，所述方法包括：a）将所述至少一个关键字与所述出价相关联，其中所述搜索查询与所述至少一个关键字相关联，以及b）确定与所述至少一个关键字相关联的所述出价的金额 与用于响应于与至少一个关键字相关联的搜索查询而生成的搜索结果列表相关联地放置该广告。 该出价至少部分地基于其他广告客户与第一广告商竞争的投标，以放置其他广告，期望所确定的投标可能引起其他广告商的出价所需的改变。

公开(公告)号：US20050137939A1

公开(公告)日：2005-06-23

申请号：US10743520

申请日：2003-12-19

申请人： Hermann Calabria ,  Francine Chen ,  Ayman Farahat ,  Daniel Greene

发明人： Hermann Calabria ,  Francine Chen ,  Ayman Farahat ,  Daniel Greene

IPC分类号： G06Q30/00 ,  G06F17/60

CPC分类号： G06Q30/02 ,  G06Q30/0601

摘要： A server-based method of automatically generating a plurality of bids for an advertiser for placement of at least one advertisement in association with a search results list is provided. The method includes: a) receiving at least one candidate advertisement, b) creating a list of candidate keywords, c) estimating a click-through rate for each advertisement-keyword pair, d) calculating a return on advertising investment (ROAI) for each advertisement-keyword pair, and e) calculating a bid amount for each advertisement-keyword pair. In another aspect, a server-based method of generating a bid for placement of an advertisement in association with a search results list is provided. In other aspects, a method of selecting one or more keywords in conjunction with the bid is provided as well as a method of determining a return on advertising investment (ROAI) information for an advertiser in conjunction with the bid is provided.

摘要翻译： 提供了一种基于服务器的方法，用于为广告商自动生成多个出价以便放置与搜索结果列表相关联的至少一个广告。 该方法包括：a）接收至少一个候选广告，b）创建候选关键字列表，c）估计每个广告关键字对的点击率，d）计算每个广告投放的广告投资回报率（ROAI） 广告关键字对，以及e）计算每个广告关键字对的出价金额。 另一方面，提供了一种与搜索结果列表相关联地生成用于放置广告的投标的基于服务器的方法。 在其他方面，提供了与投标一起选择一个或多个关键字的方法，并且提供了一种确定与投标结合的广告商的广告投资回报（ROAI）信息的方法。