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公开(公告)号：US20060171884A1
公开(公告)日：2006-08-03
申请号：US11303608
申请日：2005-12-16
申请人： Ian Foltz , Chadwick King , Peter Ling , Jaspal Kang , Kathy Manchulenko , Francine Chen , Caroline Scatena , Bruce Keyt , Edwin Madison , Wayne Godfrey , Stanislaw Morkowski , Jennifer Richardson
发明人： Ian Foltz , Chadwick King , Peter Ling , Jaspal Kang , Kathy Manchulenko , Francine Chen , Caroline Scatena , Bruce Keyt , Edwin Madison , Wayne Godfrey , Stanislaw Morkowski , Jennifer Richardson
IPC分类号： A61K51/00 , C07H21/04 , C12P21/06 , A61K39/395 , C12N5/06
CPC分类号： C07K16/40 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N2500/04
摘要： Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.
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公开(公告)号：US20210052352A1
公开(公告)日：2021-02-25
申请号：US16546195
申请日：2019-08-20
申请人： Jennifer Richardson
发明人： Jennifer Richardson
摘要： The present invention is an improved dental drill and system of assisting patients with anxiety due to dental visits. The Audio Drill system collects data such as music and time for the purposes of receiving audio data packets from a mobile device. Mobile devices such as smart phones, tablets, Internet computers, and other hand-held mobile devices are ideal for submitting music to the proposed invention. The affiliations are determined based upon the audio date and other critical markers. The system may even be enhanced by use of features tailored by the user.
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公开(公告)号：US06355430B1
公开(公告)日：2002-03-12
申请号：US09470614
申请日：1999-12-22
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The invention concerns the use of KIAA0101 nucleic acids and polypeptides in prostate cancer diagnostic and drug screening methods.
摘要翻译： 本发明涉及KIAA0101核酸和多肽在前列腺癌诊断和药物筛选方法中的应用。
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公开(公告)号：US6004940A
公开(公告)日：1999-12-21
申请号：US350215
申请日：1994-12-06
IPC分类号： A61K38/00 , C07K16/00 , C07K16/10 , C07K16/28 , C12N15/13 , C12N15/67 , C12N15/85 , C12P21/08 , A61K48/00
CPC分类号： C07K16/1063 , C07K16/00 , C07K16/1072 , C07K16/2866 , C12N15/67 , C12N15/85 , A61K2039/505 , A61K38/00 , C07K2317/21 , C07K2317/55 , C07K2317/622 , C07K2317/81 , C07K2317/82 , C07K2319/00
摘要： The present invention relates to a method by which one can target an undesired target molecule or target antigen, preferably an endogenous protein. The method comprises the intracellular expression of an antibody capable of binding to the target. A DNA sequence is delivered to a cell, the DNA sequence contains a sufficient number of nucleotides coding for the portion of an antibody capable of binding to the target operably linked to a promoter that will permit expression of the antibody in the cell(s) of interest. The antibody is then expressed intracellularly and binds to the target, thereby disrupting the target from its normal actions.
摘要翻译： 本发明涉及可以靶向不想要的靶分子或靶抗原，优选靶向内源蛋白的方法。 该方法包括能够结合靶标的抗体的细胞内表达。 将DNA序列递送至细胞，DNA序列含有足够数目的核苷酸，该核苷酸编码能够与可操作地连接至启动子的能够结合靶的部分的部分，所述启动子将允许抗体在细胞中表达 利益。 抗体然后在细胞内表达并与目标物结合，从而使目标不受其正常作用的干扰。
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公开(公告)号：US11642191B2
公开(公告)日：2023-05-09
申请号：US16546195
申请日：2019-08-20
申请人： Jennifer Richardson
发明人： Jennifer Richardson
IPC分类号： A61C3/02 , A61C19/00 , H04L67/125 , H04W4/80 , H04L65/60
CPC分类号： A61C3/02 , A61C19/00 , H04L65/60 , H04L67/125 , H04W4/80 , A61C2203/00
摘要： The present invention is an improved dental drill and system of assisting patients with anxiety due to dental visits. The Audio Drill system collects data such as music and time for the purposes of receiving audio data packets from a mobile device. Mobile devices such as smart phones, tablets, Internet computers, and other hand-held mobile devices are ideal for submitting music to the proposed invention. The affiliations are determined based upon the audio date and other critical markers. The system may even be enhanced by use of features tailored by the user.
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公开(公告)号：US20050251474A1
公开(公告)日：2005-11-10
申请号：US11026627
申请日：2004-12-30
摘要： A program for purchasing homes is disclosed. The program is primarily intended for individuals with a poor or sub prime credit rating that precludes them from qualifying for conventional home loan financing. The individuals improve their credit rating as part of the program. The program is preferably operated as a franchise in which franchisees initially purchase homes on behalf of the individuals, lease the homes to the individuals according to a contract entered prior to purchasing the home and, upon successful fulfillment of the lease, the home is sold to the individual using conventional financing. The fulfillment of the lease-to-own contract assists in improving the individual's credit rating and assists in positioning the individual to qualify for conventional home loan financing.
摘要翻译： 披露了一个采购房屋的方案。 该计划主要面向贫穷或次要信用评级的个人，排除了他们排除常规住房贷款融资资格。 个人提高信用评级作为计划的一部分。 该计划最好作为特许经营权，特许经营者最初代表个人购买房屋，根据在购买房屋之前输入的合同将房屋租赁给个人，并且在成功履行租赁后，将房屋出售给 个人使用常规融资。 履行租赁至自己的合同有助于提高个人的信用评级，并协助个人定位以适应常规住房贷款融资。
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7.发明授权Peptides derived from the ENV gene of the feline immunodeficiency virus and their applications 有权源自猫免疫缺陷病毒的ENV基因的肽及其应用公开(公告)号：US06391304B1
公开(公告)日：2002-05-21
申请号：US09529377
申请日：2000-05-19
IPC分类号： A61K3921
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/15022
摘要： The invention is drawn is to peptides encoded by the feline immunodeficiency virus (FIV) env gene and their immunoprophylactic applications (prevention and treatment of feline immunodeficiency). Said peptides, capable of inducing a certain degree of protection against FIV infection are selected from the group consisting of: peptides containing 12 to 19 amino acids which correspond to the following: Lys-Lys-Gly-Leu-Gln-Gln-Leu-Gln-Glu-Trp-Glu-Asp-Trp-Val -Gly-Trp-Ile-Gly-Asn (SEQ ID NO:1); and peptides of not more than 50 amino acids comprising said sequence set forth by SEQ ID NO:1.
摘要翻译： 本发明描述了由猫免疫缺陷病毒（FIV）env基因及其免疫预防应用（猫免疫缺陷的预防和治疗）编码的肽。 能够诱导针对FIV感染的一定程度保护的所述肽选自：含有对应于以下的12至19个氨基酸的肽：Lys-Lys-Gly-Leu-Gln-Gln-Leu-Gln -Glu-Trp-Glu-Asp-Trp-Val-Gly-Trp-Ile-Gly-Asn（SEQ ID NO：1）; 以及包含SEQ ID NO：1所示的所述序列的不超过50个氨基酸的肽。
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8.发明申请公开(公告)号：US20090148834A1
公开(公告)日：2009-06-11
申请号：US11820705
申请日：2007-06-20
申请人： Jennifer Richardson , John Monahan
发明人： Jennifer Richardson , John Monahan
CPC分类号： G01N33/573 , C12N9/90 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , C12Y501/99004 , G01N33/574 , G01N33/57434 , G01N2333/99
摘要： Methods for identifying patients having or at risk of developing prostate cancer (including hormone refractory or androgen independent prostate cancer) and patients having or at risk of developing a cancer arising from metastasis if a prostate cancer to another tissue, e.g., liver and lymph node, by measuring the expression or activity of alpha-methylacyl-CoA racemase are described. The invention also provides: methods of screening for compounds that can be used to treat prostate cancer (including hormone refractory or androgen independent prostate cancer) or metastases of prostate cancer by screening for compounds that modulate the expression or activity of the alpha-methylacyl-CoA racemase polypeptides or nucleic acids; a process for modulating (i.e., reducing) alpha-methylacyl-CoA racemase polypeptide or nucleic acid expression or activity, e.g., using the screened compounds; and methods for selecting patients for therapy with a compound that reduces the activity or expression of alpha-methylacyl-CoA racemase as well as methods for determining whether such a therapy should be continued in a patient.
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公开(公告)号：US06485921B1
公开(公告)日：2002-11-26
申请号：US09220399
申请日：1998-12-24
IPC分类号： G01N33574
CPC分类号： C12N9/93 , G01N33/57434 , G01N2500/00 , G01N2800/52
摘要： The invention concerns ubiquitin-conjugating enzyme-like protein (UBCLP) nucleic acid molecules, polypeptides, antibodies, and modulators. The invention also concerns screening assays which can be used to identify compounds useful for the treatment of prostate cancer and diagnostic assays which can be used to detect prostate cancer, and prognostic assays which can be used to monitor prostate cancer therapy.
摘要翻译： 本发明涉及泛素结合酶样蛋白（UBCLP）核酸分子，多肽，抗体和调节剂。 本发明还涉及可用于鉴定可用于治疗前列腺癌的化合物和可用于检测前列腺癌的诊断测定法的筛选测定法，以及可用于监测前列腺癌治疗的预后测定法。
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公开(公告)号：US6143520A
公开(公告)日：2000-11-07
申请号：US60659
申请日：1998-04-15
CPC分类号： C07K14/005 , C12N15/86 , C12N2740/13022 , C12N2740/13043 , C12N2740/16043 , C12N2840/203 , C12N2840/44
摘要： The present invention is related to vectors and methods for increasing the expression of a desired gene product. Preferably this invention is used with genes expressing proteins that are not well tolerated by mammalian cells or where high levels of expression are necessary. In certain preferred embodiments it can be used as part of a multi-tiered expression system and with methods of intracellularly targeting a molecule.
摘要翻译： 本发明涉及用于增加所需基因产物的表达的载体和方法。 优选地，本发明与表达哺乳动物细胞不能耐受的蛋白质或需要高水平表达的蛋白质的基因一起使用。 在某些优选实施方案中，其可以用作多层表达系统的一部分，并且可以使用细胞内靶向分子的方法。
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