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44 条记录 (耗时 0.026 秒)

    ANTIGEN BINDING PROTEINS THAT BIND WISP1
    31.
    发明申请
    ANTIGEN BINDING PROTEINS THAT BIND WISP1 审中-公开

    公开(公告)号：US20170304442A1

    公开(公告)日：2017-10-26

    申请号：US15330956

    申请日：2015-04-14

    申请人： Sorrento Therapeutics, Inc.

    发明人： Heyue Zhou ,  Gunnar F. Kaufmann

    IPC分类号： A61K39/395 ,  C07K16/30

    CPC分类号： A61K39/39558 ,  A61K39/3955 ,  C07K16/22 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/92

    摘要： There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1-binding fragments and derivatives of such antibodies, and WISP1 binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.

    Activatable Multi-Specific Antigen Binding Protein Complexes
    34.
    发明申请
    Activatable Multi-Specific Antigen Binding Protein Complexes 有权

    公开(公告)号：US20220324974A1

    公开(公告)日：2022-10-13

    申请号：US17602908

    申请日：2020-04-10

    申请人： Sorrento Therapeutics, Inc.

    发明人： Yanliang Zhang ,  Gunnar F. Kaufmann ,  Xiao He ,  Yun Wei Lai

    IPC分类号： C07K16/28

    摘要： The present disclosure provides several embodiments of multi-specific antigen binding protein complexes. In some embodiments, the multi-specific antigen binding protein complex is composed of either two or three polypeptide chains that assemble with each other to form het-erodimeric complexes comprising two different Fab regions each capable of binding two different epitopes and comprising an Fc region which is capable of exhibiting Fc effector function, thus having a relatively simple structure compared to certain other multi-specific antibodies. In one embodiment, the multi-specific antigen binding protein complex is activatable as one of the polypeptide chains that compose the protein complex carries a cleavable linker.

    Antigen Binding Proteins that Bind PD-1
    35.
    发明申请
    Antigen Binding Proteins that Bind PD-1 有权

    公开(公告)号：US20220242954A1

    公开(公告)日：2022-08-04

    申请号：US17554926

    申请日：2021-12-17

    申请人： Sorrento Therapeutics, Inc.

    发明人： Heyue Zhou ,  Barbara A. Swanson ,  John Dixon Gray ,  Gunnar F. Kaufmann ,  Edwige Gros

    IPC分类号： C07K16/28

    摘要： There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-1, PD-1-binding fragments and derivatives of such antibodies, and PD-1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-1 related disorders or conditions, including various inflammatory disorders and various cancers.

    Antigen binding proteins that bind PD-1
    37.
    发明授权
    Antigen binding proteins that bind PD-1 有权

    公开(公告)号：US11242391B2

    公开(公告)日：2022-02-08

    申请号：US16742712

    申请日：2020-01-14

    申请人： Sorrento Therapeutics, Inc.

    发明人： Heyue Zhou ,  Barbara A. Swanson ,  John Dixon Gray ,  Gunnar F. Kaufmann ,  Edwige Gros

    IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

    摘要： There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-1, PD-1-binding fragments and derivatives of such antibodies, and PD-1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-1 related disorders or conditions, including various inflammatory disorders and various cancers.

    Antigen Binding Proteins that Bind PD-1
    38.
    发明申请
    Antigen Binding Proteins that Bind PD-1 有权

    公开(公告)号：US20210130468A1

    公开(公告)日：2021-05-06

    申请号：US16742712

    申请日：2020-01-14

    申请人： Sorrento Therapeutics, Inc.

    发明人： Heyue Zhou ,  Barbara A. Swanson ,  John Dixon Gray ,  Gunnar F. Kaufmann ,  Edwige Gros

    IPC分类号： C07K16/28

    摘要： There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-1, PD-1-binding fragments and derivatives of such antibodies, and PD-1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-1 related disorders or conditions, including various inflammatory disorders and various cancers.