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公开(公告)号：US20230147852A1
公开(公告)日：2023-05-11
申请号：US17915437
申请日：2021-04-01
发明人： Damien Bresson , Min Soo Kim , Heyue Zhou , John Dixon Gray , Barbara A. Swanson , Alok Singh , Lisa Diane Kerwin
CPC分类号： C07K16/2803 , A61P35/00 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2317/33
摘要： The present disclosure provides fully human anti-LAG3 IgG class antibodies engineered to have amino acid sequence in their heavy chain variable region and/or light chain variable region to improve antigen binding, cell binding, T cell activation and cytokine release capabilities.
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公开(公告)号：US11318202B2
公开(公告)日：2022-05-03
申请号：US16374731
申请日：2019-04-03
发明人： Heyue Zhou , Gunnar F. Kaufmann
IPC分类号： A61K39/395 , C07K16/22 , C07K16/30
摘要： There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1-binding fragments and derivatives of such antibodies, and WISP1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.
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公开(公告)号：US20210130484A1
公开(公告)日：2021-05-06
申请号：US17127766
申请日：2020-12-18
发明人： Barbara A. Swanson , Heyue Zhou , Jian Cao
IPC分类号： C07K16/28
摘要： The present disclosure provides anti-CD38 IgG class antibody having improved ability to be manufactured at higher yields compared to the parent antibody having the original wild type sequence. The present disclosure provides a mutated antibody light chain that reduces cleavage heterogeneity for improved production of a homogeneous population of antibody light chains.
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公开(公告)号：US10584168B2
公开(公告)日：2020-03-10
申请号：US15589051
申请日：2017-05-08
IPC分类号： C07K16/28 , A61K39/395
摘要： There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-1, PD-1-binding fragments and derivatives of such antibodies, and PD-1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-1 related disorders or conditions, including various inflammatory disorders and various cancers.
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公开(公告)号：US10272154B2
公开(公告)日：2019-04-30
申请号：US15330956
申请日：2015-04-14
发明人： Heyue Zhou , Gunnar F. Kaufmann
IPC分类号： A61K39/395 , C07K16/30 , C07K16/22
摘要： There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1-binding fragments and derivatives of such antibodies, and WISP1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.
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公开(公告)号：US10100126B2
公开(公告)日：2018-10-16
申请号：US15066806
申请日：2016-03-10
发明人： Edwige Gros , Silpa Yalamanchili , Heyue Zhou
IPC分类号： C07K16/40 , C07K16/30 , A61K47/68 , A61K39/395 , A61K39/00
摘要： There is disclosed compositions and methods relating to or derived from anti-PSMA antibodies. More specifically, there is disclosed fully human antibodies that bind PSMA, PSMA-antibody binding fragments and derivatives of such antibodies, and PSMA-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease. There is further disclosed targeted therapies for treatment of prostate cancer having the disclosed anti-PSMA antibodies and fragments thereof targeting the therapeutic agent or cell.
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公开(公告)号：US09951144B2
公开(公告)日：2018-04-24
申请号：US15093773
申请日：2016-04-08
发明人： John Dixon Gray , Heyue Zhou
CPC分类号： C07K16/2896 , A61K39/00 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that bind CD38, CD38-antibody binding fragments and derivatives of such antibodies, and CD38-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.
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公开(公告)号：US09873741B2
公开(公告)日：2018-01-23
申请号：US15061832
申请日：2016-03-04
发明人： John Dixon Gray , Heyue Zhou , Irina Krapf
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , C07K2317/21 , C07K2317/73 , C07K2317/75 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-TIM3 antibodies. More specifically, there is disclosed fully human antibodies that bind TIM3, TIM3-antibody binding fragments and derivatives of such antibodies, and TIM3-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.
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公开(公告)号：US20170342156A1
公开(公告)日：2017-11-30
申请号：US15674401
申请日：2017-08-10
发明人： Dingqiu Huang , Barbara A. Swanson , Heyue Zhou
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-CXCR5 antibodies. More specifically, there is disclosed fully human antibodies that bind CXCR5, CXCR5-binding fragments and derivatives of such antibodies, and CXCR5-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having CXCR5 related disorders or conditions, including various inflammatory disorders and various cancers.
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公开(公告)号：US09631009B2
公开(公告)日：2017-04-25
申请号：US14473916
申请日：2014-08-29
发明人： Gunnar F. Kaufmann , Heyue Zhou , Guodi Lu
CPC分类号： C07K16/1271 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-AIP2 antibodies. More specifically, there is disclosed fully human antibodies that bind AIP2, AIP2-binding fragments and derivatives of such antibodies, and AIP2-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having AIP2 related disorders or conditions. There is also disclosed a method to treat S. aureus infections by administering an anti-AIP2 antibody described herein.
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