公开(公告)号：US08449529B2

公开(公告)日：2013-05-28

申请号：US12315890

申请日：2008-12-08

Applicant: Robin Bek ,  John Gaiser ,  Jay Qin ,  David S Utley

Inventor： Robin Bek ,  John Gaiser ,  Jay Qin ,  David S Utley

IPC: A61B18/14

CPC classification number: A61B18/1206 ,  A61B18/00 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B90/90 ,  A61B2017/00017 ,  A61B2017/00084 ,  A61B2017/00199 ,  A61B2017/00269 ,  A61B2017/00482 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/046 ,  A61B2090/0814

Abstract: A usage key card is adapted to be handled separate from a device tissue treatment device. The usage key card has a storage medium formatted to contain an identification code, which is unique to the usage key card. The usage key card is also adapted to be read by a reader separate from the device. The storage medium is also formatted, when inserted into the reader, to retain data generated pertaining to operation of the device.

Abstract translation: 使用钥匙卡适于与装置组织处理装置分开处理。 使用密钥卡具有格式化以包含对使用密钥卡是唯一的识别码的存储介质。 使用密钥卡还适于由读取器与设备分开读取。 当插入到读取器中时，存储介质也被格式化，以保留与设备的操作相关的数据。

公开(公告)号：US07731684B2

公开(公告)日：2010-06-08

申请号：US11366650

申请日：2006-03-02

Applicant: John W. Gaiser ,  Scott West ,  David S Utley ,  David Huynh

Inventor： John W. Gaiser ,  Scott West ,  David S Utley ,  David Huynh

IPC: A61M29/00

CPC classification number: A61B18/1492 ,  A61B1/00154 ,  A61M16/0493 ,  A61M25/02 ,  A61M2025/024

Abstract: Systems and methods for treating a tissue region employ an expandable structure projecting beyond the distal end of a catheter tube. A distal tail projects beyond the far end of the basket assembly. The distal tail includes a guidewire lumen that accommodates passage of a guidewire without threading the guidewire through the catheter tube.

Abstract translation: 用于治疗组织区域的系统和方法使用突出超过导管管的远端的可扩张结构。 远端的尾巴超出了篮子组件的远端。 远端尾部包括导丝管腔，该导丝腔容纳导丝的通道，而不将导丝穿过导管。

公开(公告)号：US06464697B1

公开(公告)日：2002-10-15

申请号：US09304737

申请日：1999-05-04

Applicant: Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Chin

Inventor： Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Chin

IPC: A61B1818

CPC classification number: A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Systems and methods treat a tissue region. In one arrangement, the systems and methods deploy an electrode on a support structure in a tissue region at or near the cardia of the stomach. The support structure has a proximal region and a distal region. The proximal region is enlarged in comparison to the distal region, and the electrode is carried by the enlarged proximal surface. The systems and methods advance the electrode in a path to penetrate the tissue region and couple the electrode to a source of radio frequency energy to ohmically heat tissue and create a lesion in the tissue region. In another arrangement, the systems and methods treat abnormal epithelium tissue at or near the lower esophageal sphincter by bringing an array of surface electrodes into contact with abnormal epithelium tissue. The systems and methods couple the surface electrodes to a source of radio frequency energy to ohmically heat tissue and cause necrosis of the abnormal epithelium tissue.

Abstract translation: 系统和方法处理组织区域。 在一种布置中，系统和方法将电极部署在胃贲门处或附近的组织区域中的支撑结构上。 支撑结构具有近端区域和远侧区域。 近端区域与远侧区域相比放大，并且电极由扩大的近侧表面承载。 系统和方法使电极在路径中前进以穿透组织区域并将电极耦合到射频能量源以欧姆加热组织并在组织区域中产生损伤。 在另一种布置中，系统和方法通过使表面电极阵列与异常上皮组织接触来治疗食管下括约肌或其附近的异常上皮组织。 系统和方法将表面电极耦合到射频能量源以欧姆加热组织并引起异常上皮组织的坏死。

公开(公告)号：US06355031B1

公开(公告)日：2002-03-12

申请号：US09304733

申请日：1999-05-04

Applicant: Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

Inventor： Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

IPC: A61B1818

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Multiple electrodes are coupled together in monopolar or bipolar arrays to form lesion patterns in tissue regions at or near a sphincter. A controller couples the electrodes to a generator so that a single power channel serves more than a single electrode.

Abstract translation: 多个电极以单极或双极阵列耦合在一起，以在括约肌处或附近的组织区域中形成病变图案。 控制器将电极耦合到发生器，使得单个功率通道服务于单个电极。

公开(公告)号：US08845632B2

公开(公告)日：2014-09-30

申请号：US13084973

申请日：2011-04-12

Applicant: Jay Qin ,  Robin Bek ,  John W Gaiser ,  David S Utley

Inventor： Jay Qin ,  Robin Bek ,  John W Gaiser ,  David S Utley

IPC: A61B18/14 ,  A61B18/18 ,  A61B18/00

CPC classification number: A61B18/12 ,  A61B18/18 ,  A61B2018/00267

Abstract: A device for treating a tissue region is supplied with a separate usage key card. The usage key card comprises a storage medium, which is formatted to contain an identification code unique to the usage key card. The usage key card is adapted to be read by a remote reader, to download the identification code for processing by a controller for the device. Processing of the identification code by the controller either enables or disables operation of the device according to prescribed criteria. A viewable image is generated on a display screen that changes in response to processing of the identification code.

Abstract translation: 用于处理组织区域的装置被提供有单独的使用密钥卡。 使用密钥卡包括被格式化为包含使用密钥卡唯一的识别码的存储介质。 使用密钥卡适于由远程读取器读取，以便下载用于设备的控制器进行处理的识别码。 由控制器处理识别码可以根据规定的条件启用或禁用设备的操作。 响应于识别码的处理而改变的显示画面上生成可视图像。

公开(公告)号：US08439866B2

公开(公告)日：2013-05-14

申请号：US12802324

申请日：2010-06-04

Applicant: John W. Gaiser ,  Scott West ,  David S Utley ,  David Huynh

Inventor： John W. Gaiser ,  Scott West ,  David S Utley ,  David Huynh

IPC: A61M29/00

CPC classification number: A61B18/1492 ,  A61B1/00154 ,  A61M16/0493 ,  A61M25/02 ,  A61M2025/024

Abstract: Systems and methods for treating a tissue region employ an expandable structure projecting beyond the distal end of a catheter tube. A distal tail projects beyond the far end of the basket assembly. The distal tail includes a guidewire lumen that accommodates passage of a guidewire without threading the guidewire through the catheter tube.

公开(公告)号：US07077841B2

公开(公告)日：2006-07-18

申请号：US10017906

申请日：2001-12-14

Applicant: John Gaiser ,  Scott West ,  David S Utley ,  David Huynh

Inventor： John Gaiser ,  Scott West ,  David S Utley ,  David Huynh

IPC: A61B18/18

CPC classification number: A61B18/1492 ,  A61B1/00154 ,  A61M16/0493 ,  A61M25/02 ,  A61M2025/024

Abstract: Systems and methods for treating a tissue region employ an expandable structure projecting beyond the distal end of a catheter tube. A distal tail projects beyond the far end of the basket assembly. The distal tail includes a guidewire lumen that accommodates passage of a guidewire without threading the guidewire through the catheter tube.

公开(公告)号：US06827713B2

公开(公告)日：2004-12-07

申请号：US09974750

申请日：2001-10-10

Applicant: Robin Bek ,  John Gaiser ,  Jay Qin ,  David S Utley

Inventor： Robin Bek ,  John Gaiser ,  Jay Qin ,  David S Utley

IPC: A61B1900

CPC classification number: A61B18/1206 ,  A61B18/00 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B90/90 ,  A61B2017/00017 ,  A61B2017/00084 ,  A61B2017/00199 ,  A61B2017/00269 ,  A61B2017/00482 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/046 ,  A61B2090/0814

Abstract: A device for treating a tissue region is supplied with a separate usage key card. The usage key card comprises a storage medium, which is formatted to contain an identification code unique to the usage key card. The usage key card is adapted to be read by a remote reader, to download the identification code for processing by a controller for the device. Processing of the identification code by the controller either enables or disables operation of the device according to prescribed criteria.

Abstract translation: 用于处理组织区域的装置被提供有单独的使用密钥卡。 使用密钥卡包括被格式化为包含使用密钥卡唯一的识别码的存储介质。 使用密钥卡适于由远程读取器读取，以便下载用于设备的控制器进行处理的识别码。 由控制器处理识别码可以根据规定的条件启用或禁用设备的操作。

公开(公告)号：US06802841B2

公开(公告)日：2004-10-12

申请号：US09994379

申请日：2001-11-26

Applicant: David S Utley ,  John W Gaiser ,  Rachel Croft

Inventor： David S Utley ,  John W Gaiser ,  Rachel Croft

IPC: A61B1818

CPC classification number: A61B18/1477 ,  A61B1/31 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00482 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Systems and methods apply a selected treatment agent or agents into contact with tissue at or in the region of a dysfunctional sphincter (in the case of GERD, fecal incontinence, or other dysfunctional sphincter disorders) to affect improved sphincter barrier function and/or to disrupt abnormal nerve pathways. The treatment agent can include at least one cytokine and/or at least one tissue bulking agent and/or at least one vanilloid compound to evoke a desired tissue response. The systems and methods can be used a primary treatment modality, or applied as a supplementary treatment before, during or after a primary intervention.

Abstract translation: 系统和方法将选定的治疗剂或药剂与功能异常括约肌区域（或GERD，大便失禁或其他功能失调的括约肌疾病）区域或组织接触，以影响改善的括约肌屏障功能和/或破坏 异常神经通路。 处理剂可以包括至少一种细胞因子和/或至少一种组织填充剂和/或至少一种香草酸化合物以引起所需的组织应答。 这些系统和方法可以用作主要治疗方式，或在主要干预之前，期间或之后作为补充治疗应用。

公开(公告)号：US08161976B2

公开(公告)日：2012-04-24

申请号：US11906457

申请日：2007-10-02

Applicant: David S Utley ,  John W Gaiser ,  Rachel Croft

Inventor： David S Utley ,  John W Gaiser ,  Rachel Croft

IPC: A61B17/00

CPC classification number: A61B18/1492 ,  A61B18/1477 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00553 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/1425 ,  A61M25/0084

Abstract: Systems and methods that treat disorders of the gastrointestinal tract by applying one or more treatment agents to tissue at or near the region where abnormal neurological symptoms or abnormal tissue conditions exist. The treatment agent is selected to either disrupt the abnormal nerve pathways and/or to alleviate the abnormal tissue conditions. The treatment agent can include at least one cytokine and/or at least one vanilloid compound to evoke a desired tissue response. The systems and methods can be used a primary treatment modality, or as a neoadjuvent or adjuvant treatment modality.

Abstract translation: 通过将一种或多种治疗剂施用于存在异常神经症状或异常组织病状的区域处或附近的组织来治疗胃肠道疾病的系统和方法。 选择治疗剂以破坏异常神经通路和/或减轻异常组织状况。 治疗剂可以包括至少一种细胞因子和/或至少一种香草酸化合物以引起所需的组织应答。 系统和方法可以用作主要治疗方式，或作为新辅助治疗方式。