公开(公告)号：US20150017172A1

公开(公告)日：2015-01-15

申请号：US14379867

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/30 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与SEQ ID NO：5所示的氨基酸序列具有80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 氨基酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。

公开(公告)号：US20150004171A1

公开(公告)日：2015-01-01

申请号：US14379876

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/18 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancers. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancers, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供了靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体而言，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与氨基的序列同一性为80％以上的氨基酸序列具有免疫学活性的抗体或其片段 酸序列和用于治疗和/或预防癌症的药物组合物，其包含所述抗体或其片段作为活性成分。