公开(公告)号：US09982059B2

公开(公告)日：2018-05-29

申请号：US15092469

申请日：2016-04-06

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi Okano ,  Takayoshi Ido ,  Takanori Saito ,  Shinichi Kobayashi

IPC: C07K16/30 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/3015 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3053 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734

Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

公开(公告)号：US09260513B2

公开(公告)日：2016-02-16

申请号：US14379868

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  A61K39/395 ,  C07K16/18 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与SEQ ID NO：5所示的氨基酸序列具有80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 氨基酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。

公开(公告)号：US09266958B2

公开(公告)日：2016-02-23

申请号：US14379867

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06

CPC classification number: C07K16/30 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与SEQ ID NO：5所示的氨基酸序列具有80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 氨基酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。

公开(公告)号：US09416191B2

公开(公告)日：2016-08-16

申请号：US14452746

申请日：2014-08-06

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: A61K39/395 ,  C07K16/30 ,  C07K14/47 ,  C07K16/28

CPC classification number: C07K16/30 ,  A61K39/395 ,  C07K14/4748 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract translation: 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。

公开(公告)号：US09273130B2

公开(公告)日：2016-03-01

申请号：US14379876

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancers. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancers, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供了靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体而言，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与氨基的序列同一性为80％以上的氨基酸序列具有免疫学活性的抗体或其片段 酸序列和用于治疗和/或预防癌症的药物组合物，其包含所述抗体或其片段作为活性成分。

公开(公告)号：US20150044221A1

公开(公告)日：2015-02-12

申请号：US14379868

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与SEQ ID NO：5所示的氨基酸序列具有80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 氨基酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。

公开(公告)号：US20150017172A1

公开(公告)日：2015-01-15

申请号：US14379867

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/30 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与SEQ ID NO：5所示的氨基酸序列具有80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 氨基酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。

公开(公告)号：US20150004171A1

公开(公告)日：2015-01-01

申请号：US14379876

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/18 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancers. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancers, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供了靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体而言，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与氨基的序列同一性为80％以上的氨基酸序列具有免疫学活性的抗体或其片段 酸序列和用于治疗和/或预防癌症的药物组合物，其包含所述抗体或其片段作为活性成分。