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31 条记录 (耗时 0.046 秒)

    Immunity-inducing agent
    2.
    发明授权
    Immunity-inducing agent 有权

    公开(公告)号：US10251942B2

    公开(公告)日：2019-04-09

    申请号：US15008101

    申请日：2016-01-27

    申请人： TORAY INDUSTRIES, INC.

    发明人： Akira Kurihara ,  Fumiyoshi Okano

    IPC分类号： A61K39/00 ,  A61K38/16 ,  A61K35/17 ,  C12N5/0783 ,  C12N5/0784 ,  C12Q1/6886 ,  C07K1/00

    摘要： An immunity-inducing agent comprising as an effective ingredient(s) a polypeptide(s) selected from the polypeptides: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in SEQ ID NOs:2, 4, 6, 8, 10, 12 and 44 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof; which polypeptide(s) has/have an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo, is useful as a therapeutic and/or prophylactic agent for cancer, and/or the like.

    Pharmaceutical composition for treatment and/or prevention of cancer
    3.
    发明授权
    Pharmaceutical composition for treatment and/or prevention of cancer 有权
    用于治疗和/或预防癌症的药物组合物

    公开(公告)号：US09260513B2

    公开(公告)日：2016-02-16

    申请号：US14379868

    申请日：2013-02-21

    申请人： TORAY INDUSTRIES, INC.

    发明人： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

    IPC分类号： C07K16/30 ,  A61K39/395 ,  C07K16/18 ,  A61K45/06 ,  A61K39/00

    CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732

    摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

    摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与SEQ ID NO：5所示的氨基酸序列具有80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 氨基酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。

    METHOD FOR DETECTING CANCER
    4.
    发明申请
    METHOD FOR DETECTING CANCER 有权
    检测癌症的方法

    公开(公告)号：US20150198603A1

    公开(公告)日：2015-07-16

    申请号：US14415520

    申请日：2013-07-19

    申请人： TORAY INDUSTRIES, INC.

    发明人： Takayoshi Ido ,  Fumiyoshi Okano

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57496 ,  G01N33/57415 ,  G01N33/57484 ,  G01N2800/52

    摘要： This invention provides: a method for detecting a cancer, comprising measuring the expression of a polypeptide having binding reactivity through antigen-antibody reaction with an antibody against CAPRIN-1 having an amino acid sequence shown in any even-numbered SEQ ID NO shown in SEQ ID NOs: 2 to 30 in the Sequence Listing in a biological sample; a method for detecting a cancer which involves determining the presence and the amount of CAPRIN-1 in a sample of a cancer patient in order to determine the administration of a therapeutic drug targeting CAPRIN-1 to the cancer patient; and a drug and a kit for the diagnosis of a cancer, comprising an anti-CAPRIN-1 antibody.

    摘要翻译： 本发明提供：一种检测癌症的方法，包括通过抗体 - 抗体反应与具有SEQ ID NO所示SEQ ID NO所示氨基酸序列的抗体的CAPRIN-1的抗体的表达测定 编号NO：生物样品中序列表中的2〜30; 用于检测癌症的方法，其涉及确定癌症患者样品中CAPRIN-1的存在和量的量，以确定靶向CAPRIN-1的治疗药物给予癌症患者; 以及用于诊断癌症的药物和试剂盒，其包含抗CAPRIN-1抗体。

    Immune inducer
    5.
    发明授权
    Immune inducer 有权

    公开(公告)号：US11510971B2

    公开(公告)日：2022-11-29

    申请号：US15743869

    申请日：2016-08-05

    申请人： TORAY INDUSTRIES, INC.

    发明人： Akira Kurihara ,  Fumiyoshi Okano

    IPC分类号： A61K39/00 ,  C07K14/47 ,  A61K45/00 ,  A61K48/00 ,  A61K39/39 ,  C12N5/10 ,  C12N15/09 ,  A61K35/15 ,  A61K35/76 ,  A61K35/17 ,  A61P35/00

    摘要： An object of the present invention is to discover a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer. The immune inducer contains as an active ingredient, the following (i) or (ii): (i) at least one polypeptide having an immune-inducing activity and selected from the group of polypeptides (a) or (b), where: (a) polypeptides consisting of 7 or more consecutive amino acids within the region of positions 24 to 97 in the amino acid sequence represented by SEQ ID NO: 2; and (b) polypeptides comprising one to several amino acid deletions, substitutions and/or additions in the amino acid sequence of any one of the polypeptides (a); and (ii) a recombinant vector comprising at least one polynucleotide encoding any one of the polypeptides, and capable of expressing the polypeptide in vivo.

    Immunity-inducing agent
    6.
    发明授权
    Immunity-inducing agent 有权

    公开(公告)号：US11224625B2

    公开(公告)日：2022-01-18

    申请号：US16084100

    申请日：2017-03-27

    申请人： TORAY INDUSTRIES, INC.

    发明人： Takayuki Fujita ,  Fumiyoshi Okano

    IPC分类号： A61K35/76 ,  A61K39/39 ,  A61P35/00 ,  C07K14/54 ,  C07K14/555 ,  C07K14/705 ,  C07K14/47 ,  A61K39/00 ,  C12N15/09 ,  C12N15/62

    摘要： The present invention relates to a novel immunity-inducing agent for treatment and/or prevention of cancer. Specifically, the present invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from polypeptides derived from MRAP2 and modified forms thereof, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo, and a method for inducing immunity, comprising administering the immunity-inducing agent to a subject.

    METHOD FOR DETECTING CANCER
    10.
    发明申请
    METHOD FOR DETECTING CANCER 有权
    检测癌症的方法

    公开(公告)号：US20150185222A1

    公开(公告)日：2015-07-02

    申请号：US14415090

    申请日：2013-07-19

    申请人： TORAY INDUSTRIES, INC.

    发明人： Takayoshi Ido ,  Fumiyoshi Okano

    IPC分类号： G01N33/574 ,  C07K16/18

    CPC分类号： G01N33/57496 ,  C07K14/4738 ,  C07K14/4748 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/56 ,  G01N33/57492 ,  G01N33/6872 ,  G01N2333/4703

    摘要： This invention provides: a method for detecting a cancer, comprising measuring the expression of a polypeptide having binding reactivity through antigen-antibody reaction with an antibody against CAPRIN-1 having the amino acid sequence shown in any even-numbered SEQ ID NO of SEQ ID NOs: 2 to 30 in the Sequence Listing in a biological sample; a method for detecting a cancer which involves determining the presence and the amount of CAPRIN-1 in a sample of a cancer patient in order to determine the administration of a CAPRIN-1-targeting drug to the cancer patient; and a drug and a kit for the diagnosis of a cancer, comprising an anti-CAPRIN-1 antibody.

    摘要翻译： 本发明提供了一种检测癌症的方法，其特征在于，包括通过抗体 - 抗体反应与具有SEQ ID NO的偶数序列号SEQ ID NO所示的氨基酸序列的CAPRIN-1的抗体的表达， NO：生物样品中序列表中的2〜30; 用于检测癌症的方法，其涉及确定癌症患者样品中CAPRIN-1的存在和量的量，以确定向癌症患者施用CAPRIN-1靶向药物; 以及用于诊断癌症的药物和试剂盒，其包含抗CAPRIN-1抗体。