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35 条记录 (耗时 0.032 秒)

    Imidazopyridazines and use as antiasthmatic agents
    31.
    发明授权
    Imidazopyridazines and use as antiasthmatic agents 失效
    咪唑并哒嗪并用作止喘药

    公开(公告)号：US5155108A

    公开(公告)日：1992-10-13

    申请号：US648136

    申请日：1991-01-30

    申请人： Akio Miyake ,  Masaaki Kuwahara ,  Hisashi Kuriki

    发明人： Akio Miyake ,  Masaaki Kuwahara ,  Hisashi Kuriki

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： The imidazo[1,2-b]pyridazine compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, or a lower alkyl group optionally having substituent(s), R.sub.2 an R.sub.3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O)n (n=0 to 2), Alk is a straight or branched chain alkylene group containing 1-10 carbon atoms and optionally having substituent(s), or their pharmaceutically acceptable salts which possess antiallergic, anti-inflammatory and anti-PAF activities, and their production and use.

    摘要翻译： 下式的咪唑并[1,2-b]哒嗪化合物：其中R 1是氢或卤素原子，或任选具有取代基的低级烷基，R 2，R 3独立地是 氢原子，任选具有取代基的低级烷基，环烷基或任选具有取代基的苯基，或者R 2和R 3与它们所键合的相邻氮原子一起可以形成任选具有取代基的杂环 X是氧原子或S（O）n（n = 0〜2），Alk是含有1-10个碳原子并且任选具有取代基的直链或支链亚烷基，或其药学上可接受的 具有抗过敏，抗炎和抗PAF活性的盐及其生产和使用。

    Cephalosporin compounds
    33.
    发明授权
    Cephalosporin compounds 失效
    头孢菌素化合物

    公开(公告)号：US4788185A

    公开(公告)日：1988-11-29

    申请号：US726438

    申请日：1985-04-23

    申请人： Akio Miyake ,  Masahiro Kondo ,  Masahiko Fujino

    发明人： Akio Miyake ,  Masahiro Kondo ,  Masahiko Fujino

    IPC分类号： C07D277/20 ,  C07D285/08 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D505/00 ,  C07D519/00 ,  C07D501/46 ,  A61K31/545

    CPC分类号： C07D277/587 ,  C07D285/08 ,  C07D463/18 ,  C07D463/22 ,  C07D471/04 ,  C07D487/04 ,  C07D505/00

    摘要： A compound of the formula; ##STR1## wherein R.sup.0 stands for hydrogen atom, nitrogen-containing heterocyclic group, acyl group or esterified carboxyl group, Z stands for S, S.fwdarw.O, O or CH.sub.2, R.sup.4 stands for hydrogen atom, methoxy group or formamido group, R.sup.13 stands for hydrogen atom, methyl group, hydroxyl group or halogen atom and A stands for an optionally substituted imidazol-1-yl group forming a condensed ring at the 2,3- or 3,4-position or a physiologically or pharmaceutically acceptable salt or ester thereof.This compound is novel and has excellent antibacterial activity.

    摘要翻译： 式的化合物; 其中R 0表示氢原子，含氮杂环基，酰基或酯化羧基，Z表示S，S-> O，O或CH2，R4表示氢原子，甲氧基或甲酰氨基，R13 代表氢原子，甲基，羟基或卤素原子，A代表在2,3-或3,4-位上形成稠环的任选取代的咪唑-1-基，或其生理或药学上可接受的盐或 的酯。 该化合物新颖，抗菌活性优异。

    Method for producing 1-iodoalkyl acylates
    34.
    发明授权
    Method for producing 1-iodoalkyl acylates 失效
    1-碘代烷基酰化物的制备方法

    公开(公告)号：US4593115A

    公开(公告)日：1986-06-03

    申请号：US673944

    申请日：1984-11-21

    申请人： Akio Miyake ,  Masayoshi Yamaoka

    发明人： Akio Miyake ,  Masayoshi Yamaoka

    IPC分类号： C07C51/58 ,  C07C67/14 ,  C07C69/02 ,  C07C69/612 ,  C07C69/614 ,  C07C69/62 ,  C07C69/74 ,  C07C69/75

    CPC分类号： C07C69/74 ,  C07C67/14 ,  C07C69/614 ,  C07C69/75

    摘要： An 1-Iodoalkyl acylate, which is useful as the raw material for esterification of cephalosporins, penicillins, etc. is prepared in a high degree of purity and in high yield by (1) allowing a carboxylic acid iodide to react with an aldehyde, or (2) allowing a carboxylic acid chloride to react with a salt of hydriodic acid and then allowing the resulting product to react with an aldehyde, or (3) by simultaneously allowing a carboxylic acid chloride, a salt of hydriodic acid and an aldehyde to react with one another.

    摘要翻译： 通过（1）使羧酸碘化物与醛反应，以高纯度和高收率制备可用作头孢菌素，青霉素等酯化原料的1-碘烷基酰化物，或 （2）使羧酰氯与氢碘酸盐反应，然后使所得产物与醛反应，或（3）同时使羧酰氯，氢碘酸和醛的盐反应 彼此之间。