-
31.发明授权3-hydroxypyridine-2-carboxamidoesters, their preparation and their use as pharmaceuticals 失效3-羟基吡啶-2-甲酰胺酯，它们的制备及其作为药物的用途
公开(公告)号：US6020350A
公开(公告)日：2000-02-01
申请号：US985266
申请日：1997-12-04
IPC分类号： C07D213/64 , A61K31/44 , A61P9/10 , A61P11/00 , A61P43/00 , C07D213/69 , C07D213/81 , C07D213/65 , C07D213/89
CPC分类号： C07D213/81
摘要： There are described 3-hydrixypyridine-2-carboxamidoesters of the formula ##STR1## their preparation, their use for the inhibition of collagen biosynthesis and their use as pharmaceuticals for the treatment of fibrotic disorders.
摘要翻译： 描述了其配制的3-水基吡啶-2-甲酰胺酯，其制备方法，它们用于抑制胶原生物合成的用途以及它们作为用于治疗纤维化疾病的药物的用途。
-
32.发明授权Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates 失效取代的喹啉-2-甲酰胺，其制备及其作为药物的用途和中间体
公开(公告)号：US5719164A
公开(公告)日：1998-02-17
申请号：US675208
申请日：1996-07-03
IPC分类号： A61K31/47 , A61P1/16 , A61P11/00 , A61P17/00 , A61P37/00 , A61P43/00 , C07D215/48 , C07D215/60 , C07K5/078 , C07D215/20
CPC分类号： C07K5/06139 , C07D215/48
摘要： The invention relates to substituted quinoline-2-carboxylic acid amides of the formula I ##STR1## their preparation and their use, and intermediates which are formed in the preparation of the compounds of the formula I. The compounds according to the invention are used as inhibitors of prolyl 4-hydroxylase and as pharmaceuticals (medicaments) for treatment of fibrotic diseases.
摘要翻译： 本发明涉及式I的取代喹啉-2-羧酸酰胺（I）它们的制备及其用途，以及在制备式I化合物时形成的中间体。根据本发明的化合物 用作脯氨酰4-羟化酶的抑制剂和用作治疗纤维化疾病的药物（药物）。
-
公开(公告)号：US5672614A
公开(公告)日：1997-09-30
申请号：US482815
申请日：1995-06-07
申请人： Martin Bickel , Dietrich Brocks , Harald Burghard , Volkmar Gunzler , Stephan Henke , Hartmut Hanauske-Abel , Jurgen Mohr , Georg Tschank
发明人： Martin Bickel , Dietrich Brocks , Harald Burghard , Volkmar Gunzler , Stephan Henke , Hartmut Hanauske-Abel , Jurgen Mohr , Georg Tschank
IPC分类号： C07D213/81 , C07D213/82 , C07D401/14 , C07D409/14 , C07D417/14 , A61K31/445 , A61K31/455
CPC分类号： C07D213/81 , C07D213/82 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.
摘要翻译： 本发明涉及式Ⅰ（I）的吡啶-2,4-和二羧酸衍生物，其中R1，R2，R3，R4和X具有给定的含义，制备方法 的这些化合物及其用途，特别是用于影响胶原和胶原样物质代谢的药物或Clq的生物合成。
-
34.发明授权Pyridine-2,4- and -2,5-dicarboxylic acid amides and their medicinal compositions and methods of use 失效吡啶-2,4-和二羧酸酰胺及其药物组合物和使用方法
公开(公告)号：US5153208A
公开(公告)日：1992-10-06
申请号：US726727
申请日：1991-07-01
申请人： Martin Bickel , Dietrich Brocks , Harald Burghard , Volkmar Gunzler , Stephan Henke , Hartmut Hanauske-Abel , Jurgen Mohr , Georg Tschank
发明人： Martin Bickel , Dietrich Brocks , Harald Burghard , Volkmar Gunzler , Stephan Henke , Hartmut Hanauske-Abel , Jurgen Mohr , Georg Tschank
IPC分类号： C07D213/81 , C07D213/82 , C07D401/14 , C07D409/14 , C07D417/14
CPC分类号： C07D213/81 , C07D213/82 , C07D401/14 , C07D409/14 , C07D417/14
摘要： The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances or the biosynthesis of Cl.sub.q.
摘要翻译： 本发明涉及式Ⅰ（I）的吡啶-2,4-和二羧酸衍生物，其中R1，R2，R3，R4和X具有给定的含义，制备方法 的这些化合物及其用途，特别是用于影响胶原和胶原样物质代谢的药物或Clq的生物合成。
-
35.发明授权Amide-substituted 8-N-benzimidazoles, method for the production thereof, and use of the same as medicaments 有权酰胺取代的8-N-苯并咪唑，其制备方法及其用途公开(公告)号：US08163774B2
公开(公告)日：2012-04-24
申请号：US11854578
申请日：2007-09-13
申请人： Elisabeth DeFossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth DeFossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
摘要翻译： 本发明包括使用式I的氨基取代的8-N-苯并咪唑化合物，其中R3，R4-R5，R11和R20-R21在下文中定义，其显示出治疗上可用的降血糖作用。 这些化合物特别适用于治疗糖尿病。
-
36.发明授权Amino-substituted 8-N-benzimidazoles and methods for their use in blood sugar disorders 有权氨基取代的8-N-苯并咪唑及其用于血糖障碍的方法公开(公告)号：US08003668B2
公开(公告)日：2011-08-23
申请号：US11855231
申请日：2007-09-14
申请人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Elisabeth Defossa , Karl Schoenafinger , Gerhard Jaehne , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D401/04 , A61K31/454
摘要： The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
摘要翻译： 本发明包括使用式I的氨基取代的8-N-苯并咪唑化合物，其中R3，R4-R5，R11和R20-R21在下文中定义，其显示出治疗上可用的降血糖作用。 这些化合物特别适用于治疗糖尿病。
-
37.发明授权Substituted 8-aminoalkoxy-xanthine compounds and compositions useful in the treatment of hyperlipidemia and diabetes 有权取代的8-氨基烷氧基 - 黄嘌呤化合物和可用于治疗高脂血症和糖尿病的组合物公开(公告)号：US07879864B2
公开(公告)日：2011-02-01
申请号：US11674261
申请日：2007-02-13
申请人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D473/02 , A61K31/522 , A61P3/10 , A61P3/06
CPC分类号： C07D473/04
摘要： Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthines of formula I and their derivatives: wherein the various R-groups are defined herein. These compounds may be combined with other secondary active compounds which also are effective in the treatment of said disorders and the disease states or physiological manifestations arising therefrom.
摘要翻译： 公开了用于治疗升高的血糖水平的化合物和由此产生的生理和代谢紊乱，其是酶二肽基肽酶IV（DDP-IV）的抑制剂，并且包含式I的新型取代的双环8-吡咯烷基亚基黄嘌呤及其衍生物：其中 本文定义了各种R基团。 这些化合物可以与其它二级活性化合物组合，其也可有效治疗所述疾病以及由此产生的疾病状态或生理表现。
-
38.发明授权Substituted bicyclic 8-pyrrolidinoxanthines, methods for their production, pharmaceutical formulations and their use 有权取代的双环8-吡咯烷子基黄嘌呤，其生产方法，药物制剂及其用途公开(公告)号：US07838528B2
公开(公告)日：2010-11-23
申请号：US11623770
申请日：2007-01-17
申请人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Lothar Schwink , Holger Wagner , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Gerhard Jaehne , Elisabeth Defossa , Lothar Schwink , Holger Wagner , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D473/06 , C07D473/04 , A61K31/522 , A61P3/10 , C07D487/04 , A61P3/06
CPC分类号： C07D519/00
摘要： Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are hereinafter defined. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds. Particular blood glucose disorders treatable thereby include type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerotic diseases and the like.
摘要翻译： 公开了用于治疗升高的血糖水平的化合物和由其引起的生理和代谢紊乱，并且包含新颖的取代的双环8-吡咯烷基亚基黄嘌呤及其式I的衍生物：其中各种R基团在下文中定义。 本发明还包括包含它们的药物组合物以及这些化合物的制备方法。 因此可治疗的特定血糖障碍包括2型糖尿病，胰岛素抵抗，高血糖症，动脉硬化疾病等。
-
公开(公告)号：US07227006B2
公开(公告)日：2007-06-05
申请号：US10348081
申请日：2003-01-21
申请人： Marcus Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marcus Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
摘要翻译： 本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。 此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于 治疗胰岛素抵抗或2型糖尿病。
-
40.发明授权
公开(公告)号：US5726305A
公开(公告)日：1998-03-10
申请号：US675155
申请日：1996-07-03
IPC分类号： A61K31/47 , A61P1/16 , A61P11/00 , A61P17/00 , A61P37/00 , A61P43/00 , C07D215/48 , C07D215/60 , C07K5/078 , C07D215/14 , C07D215/20
CPC分类号： C07K5/06139 , C07D215/48
摘要： The invention relates to substituted quinoline-2-carboxylic acid amides of the formula I ##STR1## their preparation and their use, and intermediates which are formed in the preparation of the compounds of the formula I. The compounds according to the invention are used as inhibitors of prolyl 4-hydroxylase and as pharmaceuticals (medicaments) for treatment of fibrotic diseases.
-
-
-
-
-
-
-
-
-
搜索结果
52 条记录 (耗时 0.032 秒)
