公开(公告)号：US4260751A

公开(公告)日：1981-04-07

申请号：US144482

申请日：1980-04-28

Applicant: Uwe D. Treuner

Inventor： Uwe D. Treuner

IPC: A61K31/53 ,  A61P29/00 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: Pyrazolo[1,2-a][1,2,4] benzotriazines having the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, nitro, amino, lower alkylamino, di(lower alkyl)amino, --SR.sub.4, --OR.sub.4 or halogen;R.sub.2 is hydrogen, lower alkyl or aralkyl;R.sub.3 is hydrogen, lower alkyl or a salt forming ion;R.sub.4 is hydrogen or lower alkyl; and Y is oxygen or sulfur.The compounds are useful as intermediates and as antiinflammatory agents.

Abstract translation: 其中R 1为氢，低级烷基，硝基，氨基，低级烷基氨基，二（低级烷基）氨基，-SR 4，-OR 4或 - 或具有下式的吡唑并〔1,2-a〕〔1,2,4〕苯并三嗪 卤素; R2是氢，低级烷基或芳烷基; R3是氢，低级烷基或形成盐的离子; R4是氢或低级烷基; Y是氧或硫。 该化合物可用作中间体和抗炎剂。

公开(公告)号：US4169947A

公开(公告)日：1979-10-02

申请号：US910548

申请日：1978-05-30

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07D307/68 ,  C07D501/20 ,  C07D501/36 ,  C07D501/22 ,  C07D501/34 ,  C07D501/46

CPC classification number: C07D307/68

Abstract: 7.beta.-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.4 is lower alkyl, cycloalkyl, phenyl, substituted phenyl or certain heterocyclic groups; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio, ##STR2## or certain heterothio groups, are useful as antibacterial agents.

公开(公告)号：US4168266A

公开(公告)日：1979-09-18

申请号：US910546

申请日：1978-05-30

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: C07D333/24 ,  C07D499/00 ,  C07D499/64 ,  C07D499/66 ,  C07D499/68 ,  C07D499/70

CPC classification number: C07C255/00 ,  C07D333/24 ,  C07D499/00

Abstract: 6-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]acyl pencillins which have the formula ##STR1## wherein R is hydrogen, lower alkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl or cycloalkyl; and R.sub.4 and R.sub.5 each is hydrogen or lower alkyl, are useful as antibacterial agents.

Abstract translation: 具有式“IMAGE”的6 - [[（2-氰基甲基）氨基] -1,2-二氧代乙基]氨基]酰基青霉素，其中R是氢，低级烷基，三（低级烷基）甲硅烷基，三（低级烷基） 甲锡烷基，三卤代乙基或成盐离子; R 1是氢，低级烷基，饱和或不饱和环烷基，苯基，苯基 - 低级烷基，取代的苯基或某些杂环基; R2是氢或甲氧基; R3是氢，低级烷基，苯基 - 低级烷基或环烷基; 并且R 4和R 5各自为氢或低级烷基，可用作抗菌剂。

公开(公告)号：US4124764A

公开(公告)日：1978-11-07

申请号：US833103

申请日：1977-09-13

Applicant: Uwe D. Treuner ,  Hermann Breuer

Inventor： Uwe D. Treuner ,  Hermann Breuer

IPC: A61K31/505 ,  A61K31/535 ,  A61P29/00 ,  C07D231/38 ,  C07D487/04 ,  C07D487/14

CPC classification number: C07D231/38 ,  C07D487/04 ,  C07D487/14 ,  Y10S514/87

Abstract: New 1,7-dihydro-1-substituted-3H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidine-3-thione and 3-one mesoionic didehydro derivatives which have the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, phenyl-lower alkyl, cycloalkyl or hydroxy-lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is lower alkyl, cycloalkyl or hydroxy-lower alkyl; andX is sulfur or oxygen,Are useful as anti-inflammatory agents.

Abstract translation: 新的1,7-二氢-1-取代-3H-吡唑并[4,3-e] -1,2,4-三唑并[4,3-c]吡啶-3-硫酮和3-酮中间偶氮二氢衍生物，其中 具有下式的化合物，其中R 1是氢，低级烷基，苯基 - 低级烷基，环烷基或羟基 - 低级烷基; R2是氢或低级烷基; R3是低级烷基，环烷基或羟基 - 低级烷基; X是硫或氧，有用作抗炎剂。

公开(公告)号：US4097670A

公开(公告)日：1978-06-27

申请号：US673222

申请日：1976-04-05

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/36

CPC classification number: C07C265/00 ,  C07D333/24

Abstract: Carboxyalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, diphenyl-lower alkyl, alkali metal ion or alkaline earth metal ion; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are disclosed. These compounds are useful as antibacterial agents.

Abstract translation: 其中R为氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，成盐离子或基团R 1的羧基烷基脲基头孢菌素为其中R为氢， 甲氧基 A是1至6个碳的直链或支链亚烷基; R2是氢，低级烷基，苯基，苯基 - 低级烷基，二苯基 - 低级烷基，碱金属离子或碱土金属离子; R3是氢或低级烷基; R4是氢，低级烷基，环烷基，环烯基，环链二烯基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基或某些杂环基; R5是氢或低级烷基; R6是低级烷基; X是氢，低级烷酰氧基，或者某些杂硫基; 被披露。 这些化合物可用作抗菌剂。

公开(公告)号：US4091212A

公开(公告)日：1978-05-23

申请号：US745156

申请日：1976-11-26

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/20 ,  C07D501/36

CPC classification number: C07D333/24

Abstract: New .alpha.-hydrazinocarbonylamino cephalosporins which have the formula ##STR1## are useful as antimicrobial agents.

Abstract translation: 具有式“IMAGE”的新的α-肼基羰基氨基头孢菌素可用作抗微生物剂。

公开(公告)号：US4038271A

公开(公告)日：1977-07-26

申请号：US740163

申请日：1976-11-08

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D233/88 ,  C07D499/00 ,  C07D499/64 ,  C07D499/66 ,  C07D499/68 ,  C07D499/70

CPC classification number: C07D233/88 ,  C07D499/00

Abstract: [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylpenicillin derivatives of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; R.sub.2, R.sub.3 and R.sub.5 each are independently selected from hydrogen and lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.6 is lower alkyl; are disclosed. These compounds are useful as antibacterial agents.

公开(公告)号：US4024135A

公开(公告)日：1977-05-17

申请号：US664335

申请日：1976-03-05

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/38 ,  C07D501/44

CPC classification number: C07D333/24

Abstract: Ureido cephalosporin derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl; or certain heterocyclic groups; are disclosed. These compounds are useful as antibacterial agents.

Abstract translation: 其中R1是氢或甲氧基的式（Ⅰ）所示的脲基头孢菌素衍生物; R2是氢或低级烷基; R3是氢，低级烷基，环烷基，环烯基，环链二烯基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基; 或某些杂环基团; 被披露。 这些化合物可用作抗菌剂。

公开(公告)号：US3996219A

公开(公告)日：1976-12-07

申请号：US581446

申请日：1975-05-28

Applicant: Hermann Breuer ,  Uwe D. Treuner

Inventor： Hermann Breuer ,  Uwe D. Treuner

IPC: C07D333/24 ,  C07D501/36 ,  C07D501/22 ,  C07D501/24

CPC classification number: C07D333/24

Abstract: 3-Heterothio(.alpha.-thiocarbonylamino)cephalosporin derivatives of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

Abstract translation: 其中R为氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，形成成盐离子或基团的3-异硫代（α-硫代羰基氨基）头孢菌素衍生物 是氢，低级烷基，环低级烷基，不饱和环 - 低级烷基，苯基，取代的苯基或噻吩基; R2和R5各自为氢或低级烷基; R3是五或六元氮，硫和/或含氧环系; 和R4是低级烷基，苯基或苯基 - 低级烷基; 作为抗菌剂是有用的。

公开(公告)号：US3994893A

公开(公告)日：1976-11-30

申请号：US628277

申请日：1975-11-03

Applicant: Uwe D. Treuner

Inventor： Uwe D. Treuner

IPC: A61K31/495 ,  A61K31/535 ,  A61P29/00 ,  C07D231/14 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D231/14

Abstract: New 4-amino derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##SPC1##R.sub.1 is hydrogen, lower alkyl or a salt forming ion;R.sub.2 and R.sub.3 each is hydrogen, lower alkyl, cyclolower alkyl, phenyl, substituted phenyl, phenyl-lower alkylene, di-lower alkylamino-lower alkylene or R.sub.2 and R.sub.3 together with the nitrogen form an unsubstituted or substituted 5- or 6-membered nitrogen heterocyclic in which an additional nitrogen or oxygen may be present.R.sub.4 is hydrogen, lower alkyl or halogen.The new compounds are useful as anti-inflammatory agents.

Abstract translation: 吡唑并[1,5-a]喹喔啉-3-羧酸的新4-氨基衍生物，酯及其盐具有式+ q，10 R1是氢，低级烷基或形成盐的离子; R 2和R 3各自为氢，低级烷基，环己烷基，苯基，取代的苯基，苯基 - 低级亚烷基，二低级烷基氨基 - 低级亚烷基或R 2和R 3与氮一起形成未取代或取代的5-或6-元氮 可以存在另外的氮或氧的杂环。