公开(公告)号：US20210093707A1

公开(公告)日：2021-04-01

申请号：US16927086

申请日：2020-07-13

申请人： Valneva Austria GmbH

发明人： Jana Barbero Calzado ,  Mario Nebenführ ,  Robert Schlegl ,  Michael Weber ,  Jürgen Heindl-Wruss

IPC分类号： A61K39/12 ,  A61P31/14 ,  C07K14/18 ,  C12N7/02 ,  C12N7/06 ,  C12N7/00 ,  A61K39/39

摘要： Described herein are processes for purifying infectious Zika virus particles and uses of protamine in such processes.

公开(公告)号：US10544194B2

公开(公告)日：2020-01-28

申请号：US15272581

申请日：2016-09-22

申请人： Valneva Austria GmbH

发明人： Pär Comstedt ,  Urban Lundberg ,  Andreas Meinke ,  Markus Hanner ,  Wolfgang Schüler ,  Benjamin Wizel ,  Christoph Reinisch ,  Brigitte Grohmann ,  Robert Schlegl

IPC分类号： C07K14/20 ,  A61K39/02 ,  C12N5/07 ,  C12N15/70 ,  C07K16/12 ,  C12P21/02 ,  C12P21/00 ,  A61K39/00 ,  A61K38/00

摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.