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公开(公告)号：US20150216967A1
公开(公告)日：2015-08-06
申请号：US14258119
申请日：2014-04-22
申请人： Valneva Austria GmbH
发明人： Benjamin Wizel , Karin Riedl , Karen Lingnau , Ursula Schlosser , Jürgen Wruss , Robert Schlegl , Michael Weber , Christoph Reinisch , Ljubomir Paucz , Christoph Klade , Jee Loon Look , Christian Ruiz , Robert Seid
IPC分类号： A61K39/39 , C12N7/00 , A61K39/09 , A61K39/145 , A61K9/14 , A61K39/118
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/51 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/092 , A61K39/118 , A61K39/12 , A61K39/145 , A61K39/40 , A61K39/42 , A61K48/00 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/401 , Y02A50/412 , Y02A50/47
摘要： The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 μm.
摘要翻译： 本发明公开了液体形式的药物组合物，其包含具有氨基酸序列KLKL5KLK的肽和具有核酸序列（dIdC）13的寡脱氧核苷酸的肽，并且其中肽和寡脱氧核苷酸作为无菌可过滤纳米粒子存在于组合物中，由此形成 悬浮液，其特征在于固体颗粒的平均粒径小于1μm。
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公开(公告)号：US20170107263A1
公开(公告)日：2017-04-20
申请号：US15267372
申请日：2016-09-16
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Markus Hanner , Urban Lundberg , Andreas Meinke , Wolfgang Schüler , Benjamin Wizel
CPC分类号： C07K14/20 , A61K38/00 , A61K39/02 , A61K39/0225 , A61K2039/55505 , A61K2039/6018 , A61K2039/6031 , C07K16/12 , C07K2319/00 , C12N5/06 , C12N15/70 , C12P21/02 , Y02A50/39 , Y02A50/396 , Y02A50/40 , Y02A50/401 , Y02A50/403
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US20150232517A1
公开(公告)日：2015-08-20
申请号：US14412722
申请日：2013-07-08
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Urban Lundberg , Andreas Meinke , Markus Hanner , Wolfgang Schüler , Benjamin Wizel , Christoph Reinisch , Brigitte Grohmann , Robert Schlegl
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
摘要翻译： 本发明涉及包含外表面蛋白A（OspA）的突变片段，编码它的核酸，药物组合物（特别是用作治疗或预防疏螺旋体感染的方法中的药物）的多肽， 包括多肽和/或核酸，治疗或预防疏螺旋体感染的方法和免疫受试者的方法。
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公开(公告)号：US20230295245A1
公开(公告)日：2023-09-21
申请号：US17932226
申请日：2022-09-14
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Urban Lundberg , Andreas Meinke , Markus Hanner , Wolfgang Schüler , Benjamin Wizel , Christoph Reinisch , Brigitte Grohmann , Robert Schlegl
CPC分类号： C07K14/20 , C07K16/12 , C12P21/02 , A61K39/0225 , A61K39/02 , C12N5/06 , C12N15/70 , C07K16/1207 , C12P21/00 , A61K2039/55505
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US11208439B2
公开(公告)日：2021-12-28
申请号：US15906618
申请日：2018-02-27
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Markus Hanner , Urban Lundberg , Andreas Meinke , Wolfgang Schüler , Benjamin Wizel
IPC分类号： A61K38/00 , C07K14/20 , C07K16/12 , C12P21/02 , A61K39/02 , C12N5/07 , C12N15/70 , C12P21/00 , A61K39/00
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US20180327460A1
公开(公告)日：2018-11-15
申请号：US15906618
申请日：2018-02-27
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Markus Hanner , Urban Lundberg , Andreas Meinke , Wolfgang Schüler , Benjamin Wizel
CPC分类号： C07K14/20 , A61K38/00 , A61K39/02 , A61K39/0225 , A61K2039/55505 , A61K2039/6018 , A61K2039/6031 , C07K16/12 , C07K16/1207 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2319/00 , C12N5/06 , C12N15/70 , C12P21/00 , C12P21/02 , Y02A50/39 , Y02A50/396 , Y02A50/40 , Y02A50/401 , Y02A50/403
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US09926343B2
公开(公告)日：2018-03-27
申请号：US15267372
申请日：2016-09-16
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Markus Hanner , Urban Lundberg , Andreas Meinke , Wolfgang Schüler , Benjamin Wizel
IPC分类号： C07K14/20 , A61K39/02 , C12N5/07 , C12N15/70 , C07K16/12 , C12P21/02 , A61K39/00 , A61K38/00
CPC分类号： C07K14/20 , A61K38/00 , A61K39/02 , A61K39/0225 , A61K2039/55505 , A61K2039/6018 , A61K2039/6031 , C07K16/12 , C07K2319/00 , C12N5/06 , C12N15/70 , C12P21/02 , Y02A50/39 , Y02A50/396 , Y02A50/40 , Y02A50/401 , Y02A50/403
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US20170101446A1
公开(公告)日：2017-04-13
申请号：US15272581
申请日：2016-09-22
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Urban Lundberg , Andreas Meinke , Markus Hanner , Wolfgang Schüler , Benjamin Wizel , Christoph Reinisch , Brigitte Grohmann , Robert Schlegl
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US20220185851A1
公开(公告)日：2022-06-16
申请号：US17517477
申请日：2021-11-02
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Markus Hanner , Urban Lundberg , Andreas Meinke , Wolfgang Schüler , Benjamin Wizel
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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公开(公告)号：US10544194B2
公开(公告)日：2020-01-28
申请号：US15272581
申请日：2016-09-22
申请人： Valneva Austria GmbH
发明人： Pär Comstedt , Urban Lundberg , Andreas Meinke , Markus Hanner , Wolfgang Schüler , Benjamin Wizel , Christoph Reinisch , Brigitte Grohmann , Robert Schlegl
IPC分类号： C07K14/20 , A61K39/02 , C12N5/07 , C12N15/70 , C07K16/12 , C12P21/02 , C12P21/00 , A61K39/00 , A61K38/00
摘要： The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.
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