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    POINT SUBSELECTION FOR FAST DEFORMABLE POINT-BASED IMAGING
    31.
    发明申请
    POINT SUBSELECTION FOR FAST DEFORMABLE POINT-BASED IMAGING 有权
    基于快速基于点的成像的点选择

    公开(公告)号：US20090279739A1

    公开(公告)日：2009-11-12

    申请号：US11915752

    申请日：2006-05-31

    申请人： Michael Kaus ,  Todd McNutt ,  Vladimir Pekar

    发明人： Michael Kaus ,  Todd McNutt ,  Vladimir Pekar

    IPC分类号： G06T7/60

    CPC分类号： G06T7/30

    摘要： A method for selecting vertices for performing deformable registration of imaged objects is provided. The selected vertices form corresponding pairs, each pair including a vertex from a first imaged object and a vertex from a second imaged object. The corresponding vertex pairs are sorted in order of distance between the vertices making up the corresponding vertex pair. The corresponding vertex pair with the greatest distance is given top priority. Corresponding vertex pairs that lie within a selected distance from the selected corresponding vertex pair are discarded. In this manner, the number of vertex pairs used for deformable registration of the imaged objects is reduced and therefore allows for processing times that are clinically acceptable.

    摘要翻译： 提供了一种用于选择用于执行成像对象的变形登记的顶点的方法。 所选择的顶点形成对应的对，每对包括来自第一成像对象的顶点和来自第二成像对象的顶点。 对应的顶点对按照构成相应顶点对的顶点之间的距离的顺序进行排序。 具有最大距离的相应顶点对被赋予最高优先级。 位于距所选择的对应顶点对的选定距离内的相应顶点对被丢弃。 以这种方式，用于成像对象的可变形登记的顶点对的数量减少，因此允许临床可接受的处理时间。

    Method of segmenting a three-dimensional structure contained in an object, notably for medical image analysis
    34.
    发明授权
    Method of segmenting a three-dimensional structure contained in an object, notably for medical image analysis 有权
    分割对象中包含的三维结构的方法，特别是用于医学图像分析

    公开(公告)号：US07167172B2

    公开(公告)日：2007-01-23

    申请号：US10091050

    申请日：2002-03-05

    申请人： Michael Kaus ,  Anja Hennemuth ,  Vladimir Pekar ,  Juergen Weese

    发明人： Michael Kaus ,  Anja Hennemuth ,  Vladimir Pekar ,  Juergen Weese

    IPC分类号： G06T15/00

    CPC分类号： G06T7/149 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30004

    摘要： The invention relates to a method of segmenting a three-dimensional structure, contained in an object, from one or more two-dimensional images which represent a slice of the object. The method utilizes a deformable model whose surface is formed by a network of meshes which connect network points on the surface of the model to one another. First there are determined the meshes which intersect at least one image and a point on the surface of the structure to be segmented is searched along a search line which traverses the mesh and extends in the image. Subsequently, the position of the network points of the model is calculated anew. These steps are repeated a number of times and the model ultimately obtained, that is, after several deformations, is considered to be the segmentation of the three-dimensional structure from the two-dimensional images.

    摘要翻译： 本发明涉及一种从一个或多个二维图像中分割包含在对象中的三维结构的方法，所述二维图像表示对象的切片。 该方法利用可变模型，其表面由网格网络形成，网格网络将模型表面上的网络点彼此连接。 首先确定与至少一个图像相交的网格，并且沿着要遍历网格的搜索线搜索要分割的结构的表面上的点，并在图像中延伸。 随后，重新计算模型网络点的位置。 这些步骤重复多次，并且最终获得的模型，即，在几个变形之后，被认为是来自二维图像的三维结构的分割。

    Automatic projection of landmarks to generate additional correspondences in image registration
    36.
    发明授权
    Automatic projection of landmarks to generate additional correspondences in image registration 有权
    自动投影地标，在图像配准中产生额外的对应关系

    公开(公告)号：US09082179B2

    公开(公告)日：2015-07-14

    申请号：US14000419

    申请日：2012-02-16

    申请人： Vladimir Pekar ,  Stephane Allaire

    发明人： Vladimir Pekar ,  Stephane Allaire

    IPC分类号： G06K9/00 ,  G06T7/00

    CPC分类号： G06T7/0028 ,  G06T7/33 ,  G06T2207/10072 ,  G06T2207/20016 ,  G06T2207/30004 ,  G06T2207/30204

    摘要： When registering multiple multidimensional images based on landmarks, the system improves the distribution and density of the points in correspondence across images, which are of crucial importance for the accuracy and reliability of the resulting registration transform. Projection of input corresponding point landmarks is performed in order to automatically generate additional point correspondences. The input existing landmarks may have been manually or automatically located in the input multiple images. Projection is performed from each source landmark along one or more determined projection directions onto one or more determined projection targets in each image. The projection target(s) can be explicitly materialized or implicitly defined. Candidate new points are identified at the locations where the projection ray paths intersect with the projection target(s). Correspondence between the new points across images is transferred from the input landmarks from which they have been projected, with further distinction by projection direction and/or projection target in the case where a plurality of these was used. Subsequent registration can use all or a selected subset of all combined input landmark correspondences and correspondences between additional projected landmark points. The additional correspondences between projected landmark points contribute in refining the image registration. Such accurate, efficient and robust tools for image registration and any downstream processing, such as contour propagation or image fusion, are highly demanded for various medical applications, such as adaptive radiotherapy.

    摘要翻译： 当基于地标登记多个多维图像时，系统提高了跨图像对应的点的分布和密度，这对于所得到的注册变换的准确性和可靠性至关重要。 执行输入对应点地标的投影，以便自动产生附加点对应。 输入的现有地标可以手动地或自动地位于输入的多个图像中。 从每个源标记沿着一个或多个确定的投影方向执行投影到每个图像中的一个或多个确定的投影目标上。 投影目标可以明确地实现或隐含定义。 在投影光线路径与投影对象相交的位置识别候选新点。 跨越图像的新点之间的对应从其投影的输入地标传送，在使用多个这些点的情况下，通过投影方向和/或投影对象进一步区分。 随后的注册可以使用所有组合的输入地标对应的所有或所选择的子集，以及附加的投影地标点之间的对应。 投影地标点之间的附加对应有助于改进图像注册。 用于图像配准和任何下游处理（例如轮廓传播或图像融合）的这种精确，有效和鲁棒的工具对于诸如自适应放射治疗之类的各种医疗应用是高度要求的。

    AUTOMATIC PROJECTION OF LANDMARKS TO GENERATE ADDITIONAL CORRESPONDENCES IN IMAGE REGISTRATION
    37.
    发明申请
    AUTOMATIC PROJECTION OF LANDMARKS TO GENERATE ADDITIONAL CORRESPONDENCES IN IMAGE REGISTRATION 有权
    自动投影地图，在图像注册中生成额外的对应关系

    公开(公告)号：US20130329980A1

    公开(公告)日：2013-12-12

    申请号：US14000419

    申请日：2012-02-16

    申请人： Vladimir Pekar ,  Stephane Allaire

    发明人： Vladimir Pekar ,  Stephane Allaire

    IPC分类号： G06T7/00

    CPC分类号： G06T7/0028 ,  G06T7/33 ,  G06T2207/10072 ,  G06T2207/20016 ,  G06T2207/30004 ,  G06T2207/30204

    摘要： When registering multiple multidimensional images based on landmarks, the system improves the distribution and density of the points in correspondence across images, which are of crucial importance for the accuracy and reliability of the resulting registration transform. Projection of input corresponding point landmarks is performed in order to automatically generate additional point correspondences. The input existing landmarks may have been manually or automatically located in the input multiple images. Projection is performed from each source landmark along one or more determined projection directions onto one or more determined projection targets in each image. The projection target(s) can be explicitly materialized or implicitly defined. Candidate new points are identified at the locations where the projection ray paths intersect with the projection target(s). Correspondence between the new points across images is transferred from the input landmarks from which they have been projected, with further distinction by projection direction and/or projection target in the case where a plurality of these was used. Subsequent registration can use all or a selected subset of all combined input landmark correspondences and correspondences between additional projected landmark points. The additional correspondences between projected landmark points contribute in refining the image registration. Such accurate, efficient and robust tools for image registration and any downstream processing, such as contour propagation or image fusion, are highly demanded for various medical applications, such as adaptive radiotherapy.

    摘要翻译： 当基于地标登记多个多维图像时，系统提高了跨图像对应的点的分布和密度，这对于所得到的注册变换的准确性和可靠性至关重要。 执行输入对应点地标的投影，以便自动产生附加点对应。 输入的现有地标可以手动地或自动地位于输入的多个图像中。 从每个源标记沿着一个或多个确定的投影方向执行投影到每个图像中的一个或多个确定的投影目标上。 投影目标可以明确地实现或隐含定义。 在投影光线路径与投影对象相交的位置识别候选新点。 跨越图像的新点之间的对应从其投影的输入地标传送，在使用多个这些点的情况下，通过投影方向和/或投影对象进一步区分。 随后的注册可以使用所有组合的输入地标对应的所有或所选择的子集，以及附加的投影地标点之间的对应。 投影地标点之间的附加对应有助于改进图像注册。 用于图像配准和任何下游处理（例如轮廓传播或图像融合）的这种精确，有效和鲁棒的工具对于诸如自适应放射治疗之类的各种医疗应用是高度要求的。

    Elastic Image Registration Functionality
    38.
    发明申请
    Elastic Image Registration Functionality 有权
    弹性图像注册功能

    公开(公告)号：US20080273779A1

    公开(公告)日：2008-11-06

    申请号：US11719406

    申请日：2005-11-04

    申请人： Vladimir Pekar

    发明人： Vladimir Pekar

    IPC分类号： A61B6/03

    CPC分类号： G06T3/0081 ,  G06T7/30 ,  G06T2207/30004

    摘要： A current diagnostic image (A) and an archived diagnostic image (B) of a common region of a patient are loaded into a first memory (14) and a second memory (18). The first and second diagnostic images (A, B) are automatically aligned and registered with one another. The three 2D orthogonal views through a selected crossing point in the image (A) are concurrently displayed along with the same three orthogonal views through the corresponding crossing point in the image (B) on a display (40). A user manually corrects alignment in the first and second sets of slices that are currently displayed on the display (40) using local tools (72).

    摘要翻译： 患者的公共区域的当前诊断图像（A）和归档诊断图像（B）被加载到第一存储器（14）和第二存储器（18）中。 第一和第二诊断图像（A，B）彼此自动对准并对准。 通过图像（A）中的选择的交叉点的三个2D正交视图与通过显示器（40）上的图像（B）中的对应交叉点的相同的三个正交视图同时显示。 用户使用本地工具（72）手动地校正当前显示在显示器（40）上的第一和第二组切片中的对准。

    Method of Accounting for Tumor Motion in Radiotherapy Treatment
    39.
    发明申请
    Method of Accounting for Tumor Motion in Radiotherapy Treatment 有权
    放射治疗肿瘤运动会计方法

    公开(公告)号：US20080219406A1

    公开(公告)日：2008-09-11

    申请号：US11995337

    申请日：2006-07-10

    申请人： Michael Kaus ,  Vladimir Pekar ,  Todd Mcnutt

    发明人： Michael Kaus ,  Vladimir Pekar ,  Todd Mcnutt

    IPC分类号： A61N5/10

    CPC分类号： A61N5/103 ,  A61N5/1037 ,  A61N5/1038 ,  A61N5/1065 ,  A61N2005/1061

    摘要： A method and apparatus accounting for tumor motion during radiation therapy is provided. The method allows for radiation therapy treatments based on updated radiation therapy plans. For each fractionate radiation treatment that results in an updated radiation treatment, radiation treatment images are acquired, automatically segmented, and then subject to deformable registration to develop updated contours and an updated radiation therapy plan.

    摘要翻译： 提供了放射治疗期间肿瘤移动的方法和装置。 该方法允许基于更新的放射治疗计划的放射治疗治疗。 对于导致更新的辐射治疗的每个分级放射治疗，获取放射治疗图像，自动分割，然后进行变形注册以开发更新的轮廓和更新的放射治疗计划。

    Manual tools for model based image segmentation
    40.
    发明申请
    Manual tools for model based image segmentation 有权
    用于基于模型的图像分割的手动工具

    公开(公告)号：US20070133848A1

    公开(公告)日：2007-06-14

    申请号：US10595357

    申请日：2004-10-06

    申请人： Todd McNutt ,  Michael Kaus ,  Vladimir Pekar

    发明人： Todd McNutt ,  Michael Kaus ,  Vladimir Pekar

    IPC分类号： G06K9/00

    CPC分类号： G06T19/00 ,  G06K9/209 ,  G06K9/34 ,  G06K2009/366 ,  G06K2209/05 ,  G06T7/11 ,  G06T7/12 ,  G06T7/149 ,  G06T2200/24 ,  G06T2207/10081 ,  G06T2207/30004 ,  G06T2219/2021

    摘要： A scanner (18) acquires images of a subject. A 3D model (52) of an organ is selected from an organ model database (50) and dropped over an image of an actual organ. A best fitting means (62) globally scales, translates and/or rotates the model (52) to best fit the actual organ represented by the image. A user uses a mouse (38) to use a set of manual tools (68) to segment and manipulate the model (52)1:o match the image data. The set of tools (68) includes: a Gaussian tool (72) for deforming a surface portion of the model along a Gaussian curve, a spherical push tool (80) for deforming the surface portion along a spherical surface segment, and a pencil tool (90) for manually drawing a line to which the surface portion is redefined.

    摘要翻译： 扫描器（18）获取被摄体的图像。 从器官模型数据库（50）中选择器官的3D模型（52）并且落在实际器官的图像上。 最佳拟合装置（62）在全局范围内缩放，平移和/或旋转模型（52）以最佳地适合由图像表示的实际器官。 用户使用鼠标（38）使用一组手动工具（68）来分割和操纵模型（52）1：o匹配图像数据。 所述工具集（68）包括：用于使模型的表面部分沿着高斯曲线变形的高斯工具（72），用于使表面部分沿着球形表面段变形的球形推动工具（80）和铅笔工具 （90），用于手动绘制重新定义表面部分的线。