公开(公告)号：US4101658A

公开(公告)日：1978-07-18

申请号：US583696

申请日：1975-06-04

申请人： Mitsuru Yoshioka ,  Yuji Sendo ,  Koji Ishikura ,  Masayuki Murakami ,  Sadao Miyazaki

发明人： Mitsuru Yoshioka ,  Yuji Sendo ,  Koji Ishikura ,  Masayuki Murakami ,  Sadao Miyazaki

IPC分类号： A61K31/545 ,  C07D501/20

CPC分类号： C07D501/20 ,  Y02P20/55

摘要： Antibacterial cephalosporins of the following formula: ##STR1## WHEREIN A and B each is a hydrogen or an amino protecting group; X is a hydroxy or a carboxy protecting group; Y is a hydrogen, halogen, alkyl, alkoxy, or an alkylthio; R is a hydrogen or an alkyl; Z is a group of the formula ##STR2## (in which R.sup.1 and R.sup.2 are the same or different and are a hydrogen, optionally substituted hydrocarbon group, organic acyl, or a group of the formula ##STR3## respectively, in which M and M' are the same or different and are an oxygen or sulfur; R.sup.3 is a hydrocarbon group; R.sup.1 and R.sup.2 can be combined together directly or through a hetero atom); m is 0 or 1; and the broken line shows the presence of a double bond at position 2 or 3, preparable from the compounds shown by the above formula in which Z is an oxygen by treatment with a compound shown by the formula H.sub.2 Z; and pharmaceuticals containing these compounds.

摘要翻译： 抗细菌头孢菌素如下：其中A和B各自为氢或氨基保护基; X是羟基或羧基保护基; Y是氢，卤素，烷基，烷氧基或烷硫基; R是氢或烷基; Z是式（IMA）（其中R 1和R 2相同或不同，分别为氢，任选取代的烃基，有机酰基或式“IMAGE”的基团）的基团，其中M和M “相同或不同，为氧或硫; R3为烃基; R1和R2可以直接或通过杂原子组合在一起; m为0或1; 虚线表示在上述式表示的化合物2或3中存在双键，其中Z为氧，通过用式H2Z表示的化合物处理; 和含有这些化合物的药物。

公开(公告)号：US3987039A

公开(公告)日：1976-10-19

申请号：US446112

申请日：1974-02-26

申请人： Mitsuru Yoshioka ,  Masayuki Murakami ,  Yuji Sendo

发明人： Mitsuru Yoshioka ,  Masayuki Murakami ,  Yuji Sendo

IPC分类号： C07D501/18 ,  A61K20060101 ,  A61K31/545 ,  C07C20060101 ,  C07D20060101 ,  C07D205/00 ,  C07D279/00 ,  C07D501/04 ,  C07D501/16 ,  C07D501/24 ,  C07D501/42 ,  C07D501/46 ,  C07D501/57 ,  C07D501/60

CPC分类号： C07D501/24 ,  C07D501/18 ,  Y02P20/55

摘要： An antibacterial 7-protected amino-3-oxyiminomethyl-3-cephem-4-carboxylic acid is prepared by the reaction of a 7-protected amino-3-formyl-3-cephem-4-carboxylic acid or its reactive derivatives with a hydroxylamine compound or its reactive derivatives, the process being more suitable for large scale production when coupled with fermentative production of a 3-hydroxymethyl-3-cephem-4-carboxylic acid followed by its direct oxidation.