公开(公告)号：US08391980B2

公开(公告)日：2013-03-05

申请号：US12498982

申请日：2009-07-07

申请人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

发明人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

IPC分类号： A61N1/00

CPC分类号： A61N1/3706 ,  A61N1/37 ,  A61N1/371 ,  A61N2001/083 ,  G01R31/026

摘要： A method for detecting potential failures by a lead of an implantable medical device is provided. The method includes sensing a first signal over a first channel between a first combination of electrodes on the lead and sensing a second signal from a second channel between a second combination of electrodes on the lead. The method determines whether at least one of the first and second signals is representative of a potential failure in the lead and identifies a failure and the electrode associated with the failure based on which of the first and second sensed signals is representative of the potential failure. Optionally, when the first and second sensed signals are both representative of the potential failure, the method further includes determining whether the first and second sensed signals are correlated with one another. When the first and second sensed signals are correlated, the method declares an electrode common to both of the first and second combinations to be associated with the failure.

摘要翻译： 提供了一种用于检测可植入医疗装置的引线的潜在故障的方法。 该方法包括在引线上的第一电极组合之间的第一通道上感测第一信号，并且感测来自引线上的第二电极组合之间的第二通道的第二信号。 该方法基于第一和第二感测信号中的哪一个代表潜在故障，确定第一和第二信号中的至少一个是否代表引线中的潜在故障，并且识别故障和与故障相关联的电极。 可选地，当第一和第二感测信号都代表潜在故障时，该方法还包括确定第一和第二感测信号是否彼此相关。 当第一和第二感测信号相关时，该方法声明与故障相关联的第一和第二组合两者共同的电极。

公开(公告)号：US20110009918A1

公开(公告)日：2011-01-13

申请号：US12498982

申请日：2009-07-07

申请人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

发明人： Gene A. Bornzin ,  John W. Poore ,  Richard Williamson ,  Gabriel A. Mouchawar ,  Eric S. Fain

IPC分类号： A61N1/37

CPC分类号： A61N1/3706 ,  A61N1/37 ,  A61N1/371 ,  A61N2001/083 ,  G01R31/026

摘要： A method for detecting potential failures by a lead of an implantable medical device is provided. The method includes sensing a first signal over a first channel between a first combination of electrodes on the lead and sensing a second signal from a second channel between a second combination of electrodes on the lead. The method determines whether at least one of the first and second signals is representative of a potential failure in the lead and identifies a failure and the electrode associated with the failure based on which of the first and second sensed signals is representative of the potential failure. Optionally, when the first and second sensed signals are both representative of the potential failure, the method further includes determining whether the first and second sensed signals are correlated with one another. When the first and second sensed signals are correlated, the method declares an electrode common to both of the first and second combinations to be associated with the failure.

摘要翻译： 提供了一种用于检测可植入医疗装置的引线的潜在故障的方法。 该方法包括在引线上的第一电极组合之间的第一通道上感测第一信号，并且感测来自引线上的第二电极组合之间的第二通道的第二信号。 该方法基于第一和第二感测信号中的哪一个代表潜在故障，确定第一和第二信号中的至少一个是否代表引线中的潜在故障，并且识别故障和与故障相关联的电极。 可选地，当第一和第二感测信号都代表潜在故障时，该方法还包括确定第一和第二感测信号是否彼此相关。 当第一和第二感测信号相关时，该方法声明与故障相关联的第一和第二组合两者共同的电极。

公开(公告)号：US07797059B1

公开(公告)日：2010-09-14

申请号：US11560297

申请日：2006-11-15

申请人： Gene A. Bornzin ,  Yougandh Chitre ,  John W. Poore

发明人： Gene A. Bornzin ,  Yougandh Chitre ,  John W. Poore

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： A system for pericardial lead implantation is disclosed herein. The system includes an implantation tool and a stimulation lead. The implantation tool includes a tubular body, a first lumen, a second lumen, a stylet or guidewire, a first port, and a second port. The first and second lumens longitudinally extend through tubular body. The first port is in communication with the first lumen, and the second port is in communication with the second lumen. The stylet or guidewire is longitudinally displaceable in the first lumen and across the first port. A tissue adhesive is selectively administrable through the second port via the second lumen. The stimulation lead includes a distal end and an engagement feature. Placing the engagement feature in the first port and causing the stylet or guidewire to displace in a first direction across the first port causes the lead to attach to the implantation tool. Displacing the stylet or guidewire in a second direction opposite the first direction allows the lead to detach from the implantation tool.

摘要翻译： 本文公开了用于心包线植入的系统。 该系统包括植入工具和刺激引线。 植入工具包括管状体，第一腔，第二腔，探针或导丝，第一端口和第二端口。 第一和第二管腔纵向延伸穿过管状体。 第一端口与第一管腔连通，第二端口与第二管腔连通。 探针或导丝可在第一管腔中纵向移动并穿过第一端口。 组织粘合剂可经由第二内腔通过第二端口选择性地施用。 刺激引线包括远端和接合特征。 将接合特征放置在第一端口中并且导致探针或导丝沿第一方向跨越第一端口移位导致引线附着到植入工具。 在与第一方向相反的第二方向上置换探针或导丝允许引线从植入工具脱离。

公开(公告)号：US20100082087A1

公开(公告)日：2010-04-01

申请号：US12243674

申请日：2008-10-01

申请人： Enzo Silipo ,  Kyungmoo Ryu ,  Gene A. Bornzin ,  John W. Poore ,  Keith Victorine ,  Zoltan Somogyi ,  Nalin Perera

发明人： Enzo Silipo ,  Kyungmoo Ryu ,  Gene A. Bornzin ,  John W. Poore ,  Keith Victorine ,  Zoltan Somogyi ,  Nalin Perera

IPC分类号： A61N1/05

CPC分类号： A61N1/05 ,  A61N1/08

摘要： A lead implantation system with an introducer, a lead configured to engage with the introducer such that the introducer can convey the lead to a desired internal target location, and at least one sensor. The sensor is adapted to generate an indicator of desired engagement of the system with the desired target tissue location prior to engagement of the lead with the target tissue. Also a method of implanting an implantable patient lead including advancing a lead implantation assembly towards a desired target location along an introduction axis and monitoring at least one indicator of lead implantation assembly position along the lead introduction axis. At least one indicator can be generated by the lead implantation assembly. Advancing of the lead introduction assembly can be halted when the monitoring indicates contact with the desired target tissue. The patient lead can then be advanced towards the target tissue and fixed to the target tissue.

摘要翻译： 一种具有引导器的引线植入系统，引线被构造成与导引器接合，使得导引器可将引线传送到期望的内部目标位置，以及至少一个传感器。 所述传感器适于在所述引线与所述目标组织接合之前产生具有期望的目标组织位置的所述系统期望接合的指示器。 还有一种植入可植入患者导线的方法，包括沿着引入轴线将引线植入组件推向所需目标位置，并且沿导线引入轴监测铅植入组件位置的至少一个指示器。 至少一个指示器可以由引线注入组件产生。 当监测指示与所需目标组织接触时，引导组件的推进可以停止。 然后可以将患者导线朝向目标组织推进并固定到靶组织。

公开(公告)号：US07536227B1

公开(公告)日：2009-05-19

申请号：US11045626

申请日：2005-01-26

申请人： John W. Poore ,  Gene A. Bornzin

发明人： John W. Poore ,  Gene A. Bornzin

IPC分类号： A61N1/05 ,  A61N5/04

CPC分类号： A61N1/0556 ,  A61B5/04001 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/6885 ,  A61B2562/182

摘要： A shielded electrode assembly for nerve sensing is disclosed. The electrode assembly is a flexible and generally tubular structure that can be wrapped around and secured to the outer surface of a nerve so as to establish and maintain electrical contact therewith. The assembly includes an electrically conductive shield with conductive reference electrodes positioned at opposite ends thereof to define an isopotential reference. A sense electrode is placed within the isopotential reference and senses signals either with respect to the isopotential reference or to a sense reference electrode also positioned within the isopotential reference to a sensing device. The isopotential reference provides a region along which nerve activity propagating along the nerve can be sensed with a large attenuation of any external noise which may be present adjacent the sensing region of the nerve. The shielded electrode assembly facilitates direct, long-term nerve sensing with reduced need for filtering or signal processing.

摘要翻译： 公开了一种用于神经感测的屏蔽电极组件。 电极组件是柔性且通常为管状的结构，其可以缠绕并固定到神经的外表面，以便建立并保持与其的电接触。 该组件包括导电屏蔽，导电参考电极位于其相对端，以限定等电位参考。 感测电极放置在等电位参考中，并且相对于等电位参考信号或感测参考电极也感测信号，该感测参考电极也位于感测装置的等位基准之内。 等势参考提供了沿着神经活动传播的神经活动可以被感测到的区域，其中可能存在与神经感觉区域相邻的任何外部噪声的大衰减。 屏蔽电极组件有助于直接，长期的神经感测，减少对滤波或信号处理的需要。

公开(公告)号：US07294108B1

公开(公告)日：2007-11-13

申请号：US11046270

申请日：2005-01-27

申请人： Gene A. Bornzin ,  John W. Poore

发明人： Gene A. Bornzin ,  John W. Poore

IPC分类号： A61B5/00

CPC分类号： A61B5/042 ,  G06F19/00

摘要： A cardiac event microrecorder comprising a hermetically sealed housing is shaped and dimensioned to facilitate the subcutaneous implantation of the microrecorder in a human patient by injection through the lumen of a hypodermic needle. The housing comprises a tubular central section of an electrically insulating material, the central section having spaced apart extremities. An electrically conductive sense electrode is secured to and seals each extremity. The housing may have an interior enclosing (1) electrical circuitry for processing, storing and telemetering data representing physiologic information detected by the sense electrodes; (2) a primary cell or rechargeable battery for electrically powering the electrical circuitry; and (3) an inductively couplable charger where a rechargeable battery is used. Also disclosed are a method of subcutaneously implanting a cardiac event recorder in a patient's thoracic region, and a handheld mapping device for determining an optimum location and orientation for the cardiac event microrecorder to be implanted.

摘要翻译： 包括密封壳体的心脏事件微量记录器的形状和尺寸被设计成便于通过注射通过皮下注射针管的内腔将微量记录器皮下植入人类患者。 壳体包括电绝缘材料的管状中心部分，中心部分具有间隔开的末端。 导电感测电极固定到每个末端并密封。 壳体可以具有内部封闭（1）电路，用于处理，存储和遥测表示由感测电极检测的生理信息的数据; （2）用于为电路供电的主电池或可再充电电池; 和（3）使用可充电电池的感应式可耦合充电器。 还公开了一种在患者胸部区域皮下植入心脏事件记录器的方法，以及用于确定要植入的心脏事件微距离记录器的最佳位置和方向的手持式测绘装置。

公开(公告)号：US07103414B1

公开(公告)日：2006-09-05

申请号：US10829907

申请日：2004-04-21

申请人： John W. Poore ,  Eric Falkenberg ,  Gene A. Bornzin

发明人： John W. Poore ,  Eric Falkenberg ,  Gene A. Bornzin

IPC分类号： A61N1/18 ,  A61N1/372

CPC分类号： A61N1/37235

摘要： A combined programming wand and PSA for physician programmers. A programmer/PSA wand can be connected to known programmers and PSA application software can be installed on the programmer to provide a system with the functionality of a PSA and a programmer in a single piece of clinical equipment. The programmer/PSA wand includes electronics to sense, pace, and shock to facilitate evaluation of indwelling leads during implantation of the implantable device and leads to facilitate programming of the device. The system includes one or more displays and control inputs that can provide information to a clinician at a single point that is typically provided with separate programmer and PSA equipment. The system provides increased efficiency, reduced opportunities for errors and/or equipment malfunction, and integrated data collection.

摘要翻译： 用于医师程序员的组合编程棒和PSA。 程序员/ PSA棒可以连接到已知的程序员，PSA应用软件可以安装在程序员上，以便在单个临床设备中为系统提供PSA和程序员的功能。 编程器/ PSA棒包括用于感测，速度和冲击的电子装置，以便在植入可植入装置期间评估留置线，并且促进装置的编程。 该系统包括一个或多个显示器和控制输入，其可以在通常具有单独的编程器和PSA设备的单个点向临床医生提供信息。 该系统提供更高的效率，减少错误和/或设备故障的机会以及集成的数据收集。

公开(公告)号：US09017341B2

公开(公告)日：2015-04-28

申请号：US13352005

申请日：2012-01-17

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi ,  Xiaoyi Min

IPC分类号： A61B19/00 ,  A61N1/05 ,  A61N1/375 ,  A61N1/372 ,  A61N1/365

CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/36521 ,  A61N1/37288 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

摘要翻译： 无引线心脏内心脏医疗装置（LIMD）包括被配置为锚定在心脏的第一腔室的第一壁部分内的电极组件。 电极组件包括具有第一固定螺旋线的电极主体，从主体延伸的电极线段和位于电极线段上的第一段终止触点。 该装置还包括壳体组件，其构造成锚固在心脏的第二腔室的第二壁部分内。 壳体组件包括具有第二固定螺旋的主体，从主体延伸的壳体线段和位于壳体线段上的第二段终止触点。 该装置还包括连接器块，其通过保持第一和第二段终止触点将电极线段电连接到壳体线段。

公开(公告)号：US09008777B2

公开(公告)日：2015-04-14

申请号：US13529226

申请日：2012-06-21

申请人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

发明人： Ali Dianaty ,  Gabriel A. Mouchawar ,  Gene A. Bornzin ,  John W. Poore ,  Xiaoyi Min ,  Zoltan Somogyi ,  Richard Williamson

IPC分类号： A61N1/00 ,  A61N1/375 ,  A61N1/368

CPC分类号： A61N1/3756 ,  A61B5/042 ,  A61N1/362 ,  A61N1/368 ,  Y10T29/49002

摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.

摘要翻译： 无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。 端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。 非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。 第一电极从端盖的近端突出。 心脏内（IC）装置延伸部从电池盒的远端伸出。 该延伸部包括电连接到电池壳体的第二电极。 第二电极远离LIMD远端。 电子模块位于端盖的内部空腔内并与第一和第二电极连通。

公开(公告)号：US08700181B2

公开(公告)日：2014-04-15

申请号：US13352101

申请日：2012-01-17

申请人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

发明人： Gene A. Bornzin ,  Xiaoyi Min ,  John W. Poore ,  Zoltan Somogyi ,  Didier Theret

IPC分类号： A61N1/362

CPC分类号： A61N1/059 ,  A61N1/0573 ,  A61N1/3684 ,  A61N1/3756

摘要： A leadless intra-cardiac medical device (LIMD) configured to be implanted entirely within a heart of a patient includes a housing configured to be securely attached to an interior wall portion of a chamber of the heart, and a stabilizing intra-cardiac (IC) device extension connected to the housing. The stabilizing IC device extension may include a stabilizer arm, and/or an appendage arm, or an elongated body or a loop member configured to be passively secured within the heart.

摘要翻译： 被配置为完全植入患者心脏的无引线心脏内心脏医疗装置（LIMD）包括被构造成可靠地附接到心脏室的内壁部分的壳体，以及稳定心脏内（IC） 设备扩展连接到外壳。 稳定IC装置延伸部可以包括稳定器臂和/或附肢臂，或者被配置为被动地固定在心脏内的细长主体或环形构件。