公开(公告)号：US20120108987A1

公开(公告)日：2012-05-03

申请号：US13342864

申请日：2012-01-03

申请人： Timothy A. Fayram ,  Eric S. Fain ,  Paul A. Levine ,  Anders Björling

发明人： Timothy A. Fayram ,  Eric S. Fain ,  Paul A. Levine ,  Anders Björling

IPC分类号： A61B5/0215

CPC分类号： A61B5/0215 ,  A61B5/02108 ,  A61B5/02116 ,  A61B5/02125 ,  A61B5/0285 ,  A61B5/0295 ,  A61B5/0452 ,  A61B5/6846 ,  A61B2562/0219 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.

摘要翻译： 本文提供了可植入系统及其使用方法，用于长期监测动脉血压。 使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。 通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。 在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。 此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

公开(公告)号：US08162841B2

公开(公告)日：2012-04-24

申请号：US12474276

申请日：2009-05-29

申请人： Allen J. Keel ,  Brian Jeffrey Wenzel ,  Edward Karst ,  Wenbo Hou ,  Taraneh Ghaffari Farazi ,  Timothy A. Fayram ,  Eric S. Fain ,  Paul A. Levine

发明人： Allen J. Keel ,  Brian Jeffrey Wenzel ,  Edward Karst ,  Wenbo Hou ,  Taraneh Ghaffari Farazi ,  Timothy A. Fayram ,  Eric S. Fain ,  Paul A. Levine

IPC分类号： A61B5/02

CPC分类号： A61B5/02158 ,  A61B5/02125 ,  A61B5/0295 ,  A61B5/0452 ,  A61B5/1459 ,  A61B2562/0219 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36585 ,  G06F19/00

摘要： Certain embodiments of the present invention are related to an implantable monitoring device to monitor a patient's arterial blood pressure, where the device is configured to be implanted subcutaneously. The device includes subcutaneous (SubQ) electrodes and a plethysmography sensor. Additionally, the device includes an arterial blood pressure monitor configured to determine at least one value indicative of the patient's arterial blood pressure based on at least one detected predetermined feature of a SubQ ECG and at least one detected predetermined feature of a plethysmography signal. Alternative embodiments of the present invention are directed to a non-implantable monitoring device to monitor a patient's arterial blood pressure based on features of a surface ECG and a plethysmography signal obtained from a non-implanted sensor.

摘要翻译： 本发明的某些实施例涉及一种用于监测患者的动脉血压的可植入监测装置，其中该装置被配置为被皮下植入。 该装置包括皮下（SubQ）电极和体积描记传感器。 另外，该装置包括动脉血压监测器，其被配置为基于至少一个检测到的SubQ ECG的预定特征和至少一个检测到的体积描记信号的预定特征来确定指示患者的动脉血压的至少一个值。 本发明的替代实施例涉及一种非植入式监测装置，用于基于从非植入传感器获得的表面ECG和体积描记信号的特征来监测患者的动脉血压。

公开(公告)号：US07930017B1

公开(公告)日：2011-04-19

申请号：US11753759

申请日：2007-05-25

申请人： Eric S. Fain ,  Jay Snell ,  Katie Hoberman ,  Laleh Jalali ,  Bing Zhu ,  Jeffery D. Snell

发明人： Eric S. Fain ,  Jay Snell ,  Katie Hoberman ,  Laleh Jalali ,  Bing Zhu ,  Jeffery D. Snell

IPC分类号： A61B5/04

CPC分类号： A61B5/0402 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/6846

摘要： A method and system are provided for trending variation in coronary burden across multiple heart rate ranges. The method and system include obtaining cardiac signals having a segment of interest over a period of time where each cardiac signal has an associated heart rate that falls within at least one heart rate range. Segment variations of the segment of interest are determined and grouped based on the associated heart rates to produce distributions of segment variations that are associated with the heart rate ranges. Trending information is produced by automatically comparing the distributions of segment variations between different heart rate ranges.

摘要翻译： 提供了一种方法和系统，用于跨越多个心率范围的冠状动脉负荷的趋势变化。 所述方法和系统包括在一段时间内获得具有感兴趣区段的心脏信号，其中每个心脏信号具有落入至少一个心率范围内的相关心率。 基于相关的心率来确定和分组感兴趣区段的区段变化，以产生与心率范围相关联的区段变化的分布。 通过自动比较不同心率范围之间的段变化的分布来产生趋势信息。

公开(公告)号：US20090062667A1

公开(公告)日：2009-03-05

申请号：US11848586

申请日：2007-08-31

申请人： Timothy A. Fayram ,  Eric S. Fain ,  Paul A. Levine

发明人： Timothy A. Fayram ,  Eric S. Fain ,  Paul A. Levine

IPC分类号： A61B5/0215

CPC分类号： A61B5/0215 ,  A61B5/02108 ,  A61B5/02116 ,  A61B5/02125 ,  A61B5/0285 ,  A61B5/0295 ,  A61B5/0452 ,  A61B5/6846 ,  A61B2562/0219 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.

摘要翻译： 本文提供了可植入系统及其使用方法，用于长期监测动脉血压。 使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。 通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。 在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。 此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

公开(公告)号：US07149569B1

公开(公告)日：2006-12-12

申请号：US10737232

申请日：2003-12-15

申请人： Eric S. Fain

发明人： Eric S. Fain

IPC分类号： A61B5/04

CPC分类号： A61B5/0464 ,  A61B5/7264

摘要： A system and method for enhancing classification of tachycardias. The tachycardias are associated with a sequence of sensed cardiac complexes, each having a calculated morphology score. The method includes storing intervals corresponding to the sequence of complexes, analyzing the stored intervals, and excluding one or more of the morphology scores based upon the analyzed intervals.

摘要翻译： 一种加强心动过速分类的系统和方法。 心动过速与所感测的心脏复合物序列相关联，每个心脏复合物具有计算的形态学得分。 该方法包括存储对应于复合物序列的间隔，分析存储的间隔，以及基于分析的间隔排除一个或多个形态得分。

公开(公告)号：US06377851B1

公开(公告)日：2002-04-23

申请号：US09484868

申请日：2000-01-18

申请人： Mae-Mae Shieh ,  Jim C. Chen ,  Anthony Mo ,  Eric S. Fain

发明人： Mae-Mae Shieh ,  Jim C. Chen ,  Anthony Mo ,  Eric S. Fain

IPC分类号： A61N1362

CPC分类号： A61N1/362 ,  A61N1/3956

摘要： An implantable cardiac stimulation device including a ventricular defibrillator and a rate adaptive cardiac pacer automatically adjusts post-pacing sensing parameters dependent upon pacing rate. The device includes a pulse generator that applies stimulation pulses to a heart at a calculated variable stimulation rate as a function of physiologic demand. A sensing circuit senses ventricular activity of the heart responsive to a plurality of sensing parameters including post-pace sensing parameters and a processor adjusts the post-pace sensing parameters responsive to the selected pacing rate.

摘要翻译： 包括心室除颤器和速率自适应心脏起搏器的可植入心脏刺激装置根据起搏速率自动调节起搏后感测参数。 该装置包括脉冲发生器，其以计算的可变刺激率作为生理需求的函数将心脏的刺激脉冲施加到心脏。 感测电路响应于包括后速度感测参数的多个感测参数来感测心脏的心室活动，并且处理器响应于所选择的起搏速率来调整后速度感测参数。

公开(公告)号：US5709711A

公开(公告)日：1998-01-20

申请号：US689631

申请日：1996-08-13

申请人： Eric S. Fain

发明人： Eric S. Fain

IPC分类号： A61N1/39 ,  A61N1/00

CPC分类号： A61N1/3943

摘要： A method and apparatus for performing electrophysiologic testing on a patient's heart using an implantable pulse generator system. The system includes an implantable pulse generator such as an implantable cardioverter-defibrillator having high voltage capacitors for storing electrical energy to defibrillate the patient's heart, a means for inducing a cardiac arrhythmia, an electrode system for discharging the stored energy into the patient's heart, and an external programmer for communication with and command of the implantable pulse generator. The method comprises the steps of charging the capacitors to a selected energy level upon command from the external programmer, inducing fibrillation in the patient's heart following the charging step, and discharging the capacitors through the electrodes into the patient's heart to defibrillate the patient's heart. The method and system provides flexibility in electrophysiologic testing by allowing the physician to control the time of delivery of high voltage therapy.

摘要翻译： 一种使用可植入脉冲发生器系统对患者心脏进行电生理测试的方法和装置。 该系统包括可植入脉冲发生器，例如具有用于存储电能去除患者心脏的电压的高电压电容器的可植入心律转复除颤器，用于诱发心律失常的装置，用于将储存的能量排放到患者心脏中的电极系统，以及 用于与可植入脉冲发生器通信和命令的外部编程器。 该方法包括以下步骤：根据来自外部编程器的命令将电容器充电到选定的能级，在充电步骤之后引起患者心脏的颤动，并将电容器通过电极放入病人的心脏以除颤患者的心脏。 该方法和系统通过允许医师控制高压治疗的输送时间来提供电生理学测试的灵活性。

公开(公告)号：US5290299A

公开(公告)日：1994-03-01

申请号：US16484

申请日：1993-02-09

申请人： Eric S. Fain ,  Mary E. Bush

发明人： Eric S. Fain ,  Mary E. Bush

IPC分类号： A61B17/128 ,  A61B17/28 ,  A61B17/00

CPC分类号： A61B17/1285 ,  A61B2017/2929 ,  Y10S227/902

摘要： A system is provided for fastening an implantable medical device, for example a defibrillator lead, to the heart. A lead electrode is placed in a desired position against the pericardium, pericardial tissue is grasped with a fastening tool, and the pericardial tissue is drawn away from epicardium and toward the fastening tool. A fastening member is applied to the pericardial tissue and to the lead electrode to secure the lead in the desired position. The application tool comprises a first pair of jaws for grasping membranous tissue and drawing the tissue away from other tissues and toward the tool. A second pair of jaws is provided for holding fastener members and delivering the fastener members to the membranous tissue.

摘要翻译： 提供了一种用于将可植入医疗装置（例如除颤器引线）紧固到心脏的系统。 将引线电极放置在针对心包的期望位置，心包组织用紧固工具抓住，并将心包组织从心外膜拉出并朝向紧固工具。 将紧固构件施加到心包组织和引线电极，以将引线固定在期望的位置。 应用工具包括用于抓住膜组织并将组织远离其他组织并朝向工具拉出的第一对钳口。 提供第二对钳口用于保持紧固件并将紧固件传送到膜组织。

公开(公告)号：US07634313B1

公开(公告)日：2009-12-15

申请号：US11104382

申请日：2005-04-11

申请人： Mark W. Kroll ,  Eric S. Fain ,  Eric Falkenberg

发明人： Mark W. Kroll ,  Eric S. Fain ,  Eric Falkenberg

IPC分类号： A61N1/00

CPC分类号： A61N1/37288 ,  A61N1/3756

摘要： In one implementation, a failsafe method for implantable satellite pacemaker pacing is provided, which includes pacing with a satellite pacemaker and monitoring for a local pacing pulse with an other satellite pacemaker. This implementation further includes, pacing with a surrogate satellite pacemaker if the local pacing pulse is not detected by the other satellite pacemaker. Certain implementations may include transmitting a wireless signal from the other satellite pacemaker to a master pacemaker if the local pacing pulse is not detected by the other satellite pacemaker and using the master pacemaker to select the surrogate satellite pacemaker. Certain implementations may include monitoring for the local pacing pulse with a plurality of satellite and causing the plurality of satellite pacemakers to select the surrogate satellite pacemaker.

公开(公告)号：US07191002B1

公开(公告)日：2007-03-13

申请号：US10841105

申请日：2004-05-06

申请人： Mark Kroll ,  Eric S. Fain

发明人： Mark Kroll ,  Eric S. Fain

IPC分类号： A61N1/00

CPC分类号： A61N1/3622 ,  A61N1/3684

摘要： An improved method and device for performing anti-tachycardia pacing (ATP) to convert a ventricular tachycardia (VT) to normal sinus rhythm. Pairs of pacing/sensing electrodes are placed in or on each of the left and right ventricles. Each pair of electrodes is shorted together to produce unipolar electrodes that are used for ATP.

摘要翻译： 用于进行抗心动过速起搏（ATP）以将室性心动过速（VT）转换为正常窦性心律的改进的方法和装置。 一对起搏/感应电极放置在左心室和右心室中的每一个中。 每对电极短路在一起，产生用于ATP的单极电极。