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35 条记录 (耗时 0.035 秒)

    Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation
    33.
    发明授权
    Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation 失效
    四氢噻吩并吡啶衍生物，呋喃和吡咯类似物及其制备和用途，用于抑制血小板聚集

    公开(公告)号：US5288726A

    公开(公告)日：1994-02-22

    申请号：US941676

    申请日：1992-09-08

    申请人： Hiroyuki Koike ,  Fumitoshi Asai ,  Atsuhiro Sugidachi ,  Tomio Kimura ,  Teruhiko Inoue ,  Shigeyoshi Nishino ,  Yasunori Tsuzaki

    发明人： Hiroyuki Koike ,  Fumitoshi Asai ,  Atsuhiro Sugidachi ,  Tomio Kimura ,  Teruhiko Inoue ,  Shigeyoshi Nishino ,  Yasunori Tsuzaki

    IPC分类号： A61K31/435 ,  A61K31/135 ,  A61K31/365 ,  A61K31/4365 ,  A61P7/02 ,  C07D221/00 ,  C07D333/00 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  A01K3/14 ,  C07D513/04

    CPC分类号： C07D471/04 ,  C07D491/04 ,  C07D495/04

    摘要： Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R.sup.2 is optionally substituted alkanoyl, optionally substituted alkenoyl, optionally substituted cycloalkylcarbonyl, substituted benzoyl, or 5,6-dihydro-1,4,2-dioxazin-3-yl; R.sup.3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is --NH-- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.

    摘要翻译： 式（I）化合物：（*化学结构*）（I）其中：R1是氢，烷基，卤素，卤代烷基，羟基，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基，氨基，烷酰基，卤代烷酰基，羧基，烷氧基羰基，氨基甲酰基， 氰基，硝基，烷磺酰基，卤代烷磺酰基或氨磺酰基; R 2是任选取代的烷酰基，任选取代的烯酰基，任选取代的环烷基羰基，取代的苯甲酰基或5,6-二氢-1,4,2-二恶嗪-3-基; R3是氢，羟基，任选取代的烷氧基，芳烷氧基，烷酰氧基，烯酰氧基，环烷基羰基氧基，芳基羰基氧基，烷氧基羰基氧基，芳烷氧基羰基氧基，邻苯二甲酰氧基，（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲氧基，（5- 苯基-2-氧代-1,3-二氧杂环戊烯-4-基）甲氧基，任选取代的氨基或硝基; Y是-NH-或氧或硫; n为1至5; 和所述式（I）化合物的互变异构体和盐具有抑制血小板聚集的能力，因此可用于治疗和预防血栓形成和栓塞。

    Process for preparing 5-mercapto-1,2,3-thiadiazole salts
    34.
    发明授权
    Process for preparing 5-mercapto-1,2,3-thiadiazole salts 失效
    5-巯基-1,2,3-噻二唑盐的制备方法

    公开(公告)号：US4675412A

    公开(公告)日：1987-06-23

    申请号：US777834

    申请日：1985-09-19

    申请人： Hiroshi Yoshida ,  Teruhiko Inoue

    发明人： Hiroshi Yoshida ,  Teruhiko Inoue

    IPC分类号： C07D285/06

    CPC分类号： C07D285/06

    摘要： There is disclosed a process for preparing 5-mercapto-1,2,3-thiadiazole salts comprising reacting a hydrazone compound represented by the formula:X.sub.3 C--CH.dbd.N--NH--SO.sub.2 Arwherein X represents a halogen atom and Ar represents an aryl group, with a polysulfide compound represented by the formula:M.sub.2 S.sub.xwherein M represents an alkali metal atom or an NH.sub.4 group and x is an integer of 2 to 6.The present invention provides the 5-mercapto-1,2,3-thiadiazole salt with remarkably increased yield as compared with the conventional method.

    摘要翻译： 公开了一种制备5-巯基-1,2,3-噻二唑盐的方法，包括使由下式表示的腙化合物：X3C-CH = N-NH-SO2Ar，其中X表示卤素原子，Ar表示芳基 与由下式表示的多硫化合物：M2Sx其中M表示碱金属原子或NH4基团，x为2-6的整数。本发明提供5-巯基-1,2,3-噻二唑盐与 与常规方法相比，产量显着提高。