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72 条记录 (耗时 0.026 秒)

    Purine derivatives and methods of use thereof
    31.
    发明申请
    Purine derivatives and methods of use thereof 失效
    嘌呤衍生物及其使用方法

    公开(公告)号：US20070191301A1

    公开(公告)日：2007-08-16

    申请号：US11606577

    申请日：2006-11-30

    申请人： Prakash Jagtap ,  Andrew Salzman

    发明人： Prakash Jagtap ,  Andrew Salzman

    IPC分类号： A61K31/7076 ,  C07H19/16

    CPC分类号： C07D473/34 ,  C07H19/16

    摘要： The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ophthalmic condition, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物核心体温的方法，保护动物心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，眼科疾病，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。

    N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof
    32.
    发明申请
    N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof 失效
    N-苄基取代的吡啶基卟啉化合物及其使用方法

    公开(公告)号：US20070072825A1

    公开(公告)日：2007-03-29

    申请号：US11528082

    申请日：2006-09-26

    申请人： William Williams

    发明人： William Williams

    IPC分类号： A61K31/728 ,  C07D487/22 ,  A61K31/555 ,  A61K31/409

    CPC分类号： C07F15/025 ,  C07D487/22

    摘要： The present invention relates to N-Benzyl-Substituted Pyridyl Porphyrin Compounds, compositions comprising an effective amount of an N-Benzyl-Substituted Pyridyl Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction, urinary incontinence, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, and methods for prolonging the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of an N-Benzyl-Substituted Pyridyl Porphyrin Compound.

    摘要翻译： 本发明涉及N-苄基取代的吡啶基卟啉化合物，包含有效量的N-苄基取代的吡啶基卟啉化合物的组合物和用于治疗或预防由于暴露于反应性物质引起的损伤，勃起功能障碍，尿失禁， 肺部疾病，高氧症，神经变性疾病，肝脏疾病，心脏停搏期间的心肌损伤，炎症状况，再灌注损伤，缺血状况，心血管疾病，糖尿病，糖尿病并发症，癌症，癌症化学疗法的副作用或辐射 诱导的损伤，以及延长氧化易发生化合物的半衰期的方法，包括向有需要的受试者施用有效量的N-苄基取代的吡啶基卟啉化合物。

    Tetracyclic amino and carboxamido compounds and methods of use thereof
    33.
    发明申请
    Tetracyclic amino and carboxamido compounds and methods of use thereof 失效
    四环氨基和甲酰氨基化合物及其使用方法

    公开(公告)号：US20060287312A1

    公开(公告)日：2006-12-21

    申请号：US11354707

    申请日：2006-02-15

    申请人： Prakash Jagtap ,  Csaba Szabo

    发明人： Prakash Jagtap ,  Csaba Szabo

    IPC分类号： A61K31/5377 ,  C07D413/02

    CPC分类号： A61K31/473 ,  A61K31/496 ,  A61K31/5377 ,  C07D221/18 ,  C07D401/12 ,  C07D413/12

    摘要： The present invention relates to Tetracyclic Amino Compounds and Tetracyclic Carboxamido Compounds, compositions comprising an effective amount of a Tetracyclic Amino Compound or a Tetracyclic Carboxamido Compound and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, Parkinson's disease, renal failure, a vascular disease, a cardiovascular disease, or cancer, comprising administering to a subject in need thereof an effective amount of a Tetracyclic Amino Compound or a Tetracyclic Carboxamido Compound.

    摘要翻译： 本发明涉及四环氨基化合物和四环类羧甲酰胺化合物，包含有效量的四环氨基化合物或四环羧酰胺化合物的组合物以及治疗或预防炎性疾病，再灌注损伤，糖尿病，糖尿病并发症，再氧合损伤 由器官移植，缺血状况，帕金森氏病，肾衰竭，血管疾病，心血管疾病或癌症引起的，包括向有需要的受试者施用有效量的四环氨基化合物或四环羧酰胺化合物。

    Method of reducing intraocular pressure in humans
    37.
    发明授权
    Method of reducing intraocular pressure in humans 有权
    降低人眼内压的方法

    公开(公告)号：US08895530B2

    公开(公告)日：2014-11-25

    申请号：US13909288

    申请日：2013-06-04

    申请人： Inotek Pharmaceuticals Corporation

    发明人： Norman N. Kim ,  William K. McVicar ,  Thomas G. McCauley ,  Prakash Jagtap

    IPC分类号： A61K31/70 ,  C07H19/167 ,  A61K31/7076 ,  A61K31/495

    CPC分类号： A61K31/7076 ,  A61K9/0048 ,  A61K31/495 ,  A61K45/06 ,  C07H19/16 ,  C07H19/167

    摘要： Provided herein is a method of reducing intraocular pressure (IOP) in humans using N6-cyclopentyladenosine (CPA), CPA derivatives or prodrugs or enhanced cornea permeability formulations of CPA. In one embodiment, the invention is directed to CPA derivatives or prodrugs that are permeable to the cornea. In another embodiment, the invention is directed to uses of certain compounds in human subjects for reducing and/or controlling elevated or abnormally fluctuating IOPs in the treatment of glaucoma or ocular hypertension (OHT).

    摘要翻译： 本文提供了使用N6-环戊基腺苷（CPA），CPA衍生物或前药或CPA增强的角膜通透性制剂降低人眼内压（IOP）的方法。 在一个实施方案中，本发明涉及可透过角膜的CPA衍生物或前药。 在另一个实施方案中，本发明涉及某些化合物在人受试者中用于减少和/或控制治疗青光眼或高眼压症（OHT）的升高或异常波动的IOP的用途。

    PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF
    40.
    发明申请
    PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF 有权
    嘌呤衍生物作为腺苷A1受体激动剂及其使用方法

    公开(公告)号：US20120264706A1

    公开(公告)日：2012-10-18

    申请号：US13451613

    申请日：2012-04-20

    申请人： Prakash JAGTAP ,  Csaba SZABO ,  Andrew L. SALZMAN

    发明人： Prakash JAGTAP ,  Csaba SZABO ,  Andrew L. SALZMAN

    IPC分类号： A61K31/7076 ,  A61P9/00 ,  A61P3/04 ,  A61P25/00 ,  A61P9/10 ,  A61P3/10 ,  C07H19/16 ,  A61P3/00

    CPC分类号： C07H19/167 ,  C07D473/34 ,  C07H19/12

    摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

    摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物代谢率的方法，保护动物的心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。