-
公开(公告)号：US20180066295A1
公开(公告)日：2018-03-08
申请号：US15559152
申请日：2016-03-18
发明人： Sergio PÉREZ OZCÁRIZ , Marta PASCUAL GILABERT , Carmen María FERNÁNDEZ FERNÁNDEZ , Josep CASTELLS BOLIART , Javier ALONSO FERNÁNDEZ , Cristina LÓPEZ GÓMEZ
CPC分类号： C12P19/305 , C07H19/06 , C07H19/10 , C07H19/12 , C12P19/30 , C12Y305/04005
摘要： The invention relates to a new synthetic process for obtaining compounds of formula (I) from compounds of formula (II) by means of cytidine deaminase enzymes.
-
公开(公告)号：US09790252B2
公开(公告)日：2017-10-17
申请号：US13381587
申请日：2010-07-01
申请人： Anthony A. Sauve , Yana Cen
发明人： Anthony A. Sauve , Yana Cen
IPC分类号： A61K31/706 , C07H23/00 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/073 , C07H19/12 , C07H19/16 , C07H19/173 , C07H19/19
CPC分类号： C07H23/00 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/073 , C07H19/12 , C07H19/16 , C07H19/173 , C07H19/19
摘要： Disclosed are halogenated 2-deoxy-lactone, 2′-deoxy-nucleosides, and derivatives thereof, for example, a compound of formula (I). Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, and a method of treating a disorder is selected from the group consisting of an abnormal cellular proliferation, a viral infection, and an autoimmune disorder.
-
公开(公告)号：US20160362440A1
公开(公告)日：2016-12-15
申请号：US15155781
申请日：2016-05-16
申请人： Geron Corporation
摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
摘要翻译： 描述了正交保护的3'-氨基核苷单体及其合成的有效方法。 该方法在未保护的核苷碱基存在下采用3'-氨基的选择性保护。
-
公开(公告)号：US09498489B2
公开(公告)日：2016-11-22
申请号：US12762768
申请日：2010-04-19
申请人： Lili Liu , Stanton Gerson
发明人： Lili Liu , Stanton Gerson
IPC分类号： A61K31/7068 , C07H19/12 , A61K31/7028
CPC分类号： A61K31/706 , A61K31/131 , A61K31/495 , A61K31/7028 , A61K31/7068 , C07H19/12
摘要： A method treating cancer in a subject comprises administering to the subject a therapeutically effective amount of an antimetabolite agent that induces formation of AP sites in cancer cells of the subjects and an amount AP endonuclease inhibitor effective to potentiate the cytotoxicity of the antimetabolite agent to the cancer cells.
摘要翻译： 治疗受试者的癌症的方法包括向受试者施用治疗有效量的诱导在受试者的癌细胞中形成AP位点的抗代谢剂，以及有效增强抗代谢药物对癌症的细胞毒性的AP内切核酸酶抑制剂 细胞。
-
公开(公告)号：US09493500B2
公开(公告)日：2016-11-15
申请号：US13843439
申请日：2013-03-15
申请人： Richard Daifuku
发明人： Richard Daifuku , Anna Gall , Dmitri S. Sergueev
摘要： The present invention provides fluorinated 5-aza-2′-deoxycytidine compounds, such as 2′,2′-difluoro-5-aza-2′-deoxycytidine, compositions that include the compounds, methods for making the compounds, and methods for inhibiting DNA methyltransferase, treating solid tumors, and treating hematologic cancers by administering the compounds.
摘要翻译： 本发明提供氟化5-氮杂-2'-脱氧胞苷化合物，例如2'，2'-二氟-5-氮杂-2'-脱氧胞苷，包括该化合物的组合物，制备该化合物的方法和抑制方法 DNA甲基转移酶，治疗实体瘤，以及通过施用化合物治疗血液癌症。
-
6.发明申请VITAMIN B6 DERIVATIVES OF NUCLEOTIDES, ACYCLONUCLEOTIDES AND ACYCLONUCLEOSIDE PHOSPHONATES 审中-公开维生素B6衍生物，核苷酸和环磷酰胺磷酸酯公开(公告)号：US20160250247A1
公开(公告)日：2016-09-01
申请号：US15149010
申请日：2016-05-06
申请人： MBC PHARMA, INC.
IPC分类号： A61K31/7068
CPC分类号： A61K31/7068 , C07D213/65 , C07D213/76 , C07H19/10 , C07H19/12 , C07H19/19 , C07H19/20 , C07H19/23
摘要： Provided herein are compounds, compositions, and methods of using them to treat infections, neoplastic disease, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and ANP phosphonates conjugated with forms and/or moieties of Vitamin B6 for delivery past the cell membrane and into the cell.
摘要翻译： 本文提供了使用它们治疗感染，肿瘤性疾病，炎性疾病和疼痛的化合物，组合物和方法。 这样的化合物是与维生素B6的形式和/或部分缀合的核苷酸，非循环核苷酸和ANP膦酸酯，用于递送通过细胞膜并进入细胞。
-
公开(公告)号：US09365606B2
公开(公告)日：2016-06-14
申请号：US14276381
申请日：2014-05-13
申请人： Geron Corporation
摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
摘要翻译： 描述了正交保护的3'-氨基核苷单体及其合成的有效方法。 该方法在未保护的核苷碱基存在下采用3'-氨基的选择性保护。
-
8.发明授权Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates 有权维生素B6衍生物的核苷酸，非循环核苷酸和非循环核苷酸膦酸酯公开(公告)号：US09334300B2
公开(公告)日：2016-05-10
申请号：US14236178
申请日：2012-08-01
IPC分类号： A61K31/70 , A01N43/04 , C12N5/00 , C12N5/02 , C07H19/048 , C07H19/10 , C07D213/76 , C07D213/65 , C07H19/12 , C07H19/20 , C07H19/23 , C07H19/19
CPC分类号： A61K31/7068 , C07D213/65 , C07D213/76 , C07H19/10 , C07H19/12 , C07H19/19 , C07H19/20 , C07H19/23
摘要： Compounds and compositions are provided, as are methods of using them to treat infections, neoplastic disease, including pancreatic cancer, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and ANP phosphonates conjugated with forms and/or moieties of Vitamin B6 for delivery past the cell membrane and into the cell.
摘要翻译： 提供化合物和组合物，以及使用它们来治疗感染，肿瘤疾病，包括胰腺癌，炎性疾病和疼痛的方法。 这样的化合物是与维生素B6的形式和/或部分缀合的核苷酸，非循环核苷酸和ANP膦酸酯，用于递送通过细胞膜并进入细胞。
-
公开(公告)号：US09192620B2
公开(公告)日：2015-11-24
申请号：US14137907
申请日：2013-12-20
申请人： PHARMION LLC
IPC分类号： C07H19/12 , A61K31/7068 , C07H19/048 , A61K31/706
CPC分类号： A61K31/7068 , A61K31/706 , C07H19/048 , C07H19/12
摘要： The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacyditine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
摘要翻译： 本发明提供5-氮杂胞嘧啶的新型多晶型和假多晶型结晶形式，以及制备所述形式的方法，其中5-氮杂胞苷由下式表示：本发明还包括包含所述形式的药物组合物。
-
10.发明授权公开(公告)号：US09156874B2
公开(公告)日：2015-10-13
申请号：US13838071
申请日：2013-03-15
发明人： Junbiao Chang , Qiang Huang , Runcong Liu , Zheng Wang
IPC分类号： A61K31/70 , A01N43/04 , C07H19/10 , C07H19/12 , C07H19/20 , C07F9/6561 , C07F9/6558 , C07H19/06 , C07H19/073 , C07H19/09 , C07H19/16 , C07H19/173 , C07H19/19 , C07H19/207 , C07D405/04 , C07D473/34 , C07D473/40 , C07F9/26 , C07F9/24
CPC分类号： C07H19/10 , C07D405/04 , C07D473/34 , C07D473/40 , C07F9/2429 , C07F9/26 , C07F9/65586 , C07F9/65616 , C07H19/06 , C07H19/073 , C07H19/09 , C07H19/12 , C07H19/16 , C07H19/173 , C07H19/19 , C07H19/20 , C07H19/207
摘要： This application discloses phosphoramidate and phosphonoamidate prodrugs of alcohol-based therapeutic agents, such as nucleosides, nucleotides, acyclonucleosides, C-nucleosides, and C-nucleotides, and use of these prodrugs for treatment of diseases or disorders, including infectious diseases and cancers. This application also discloses a general method for enhancing bioavailability and/or liver-targeting property of alcohol drugs through converting the alcohol drugs to phosphoramidate or phosphonoamidate prodrugs, and methods of preparation of these prodrugs.
摘要翻译： 本申请公开了基于醇的治疗剂如核苷，核苷酸，无环鸟苷，C-核苷和C-核苷酸的氨基磷酸酯和膦酰胺酸酯前药，以及这些前药用于治疗疾病或病症，包括感染性疾病和癌症的用途。 本申请还公开了通过将醇类药物转化为氨基磷酸酯或膦酰胺酸酯前药来提高醇类药物的生物利用度和/或肝靶向性的一般方法，以及制备这些前药的方法。
-
-
-
-
-
-
-
-
-
搜索结果
276 条记录 (耗时 0.032 秒)
