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公开(公告)号：US20170340739A1
公开(公告)日：2017-11-30
申请号：US15454898
申请日：2017-03-09
申请人： TherapeuticsMD, Inc.
发明人： Janice Cacace , Peter H.R. Persicaner , Thorsteinn Thorsteinsson , Frederick Sancilio , Julia Amadio , Brian Bernick
摘要： This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
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公开(公告)号：US09248136B2
公开(公告)日：2016-02-02
申请号：US14125554
申请日：2013-01-25
申请人： TherapeuticsMD, Inc.
发明人： Brian A. Bernick , Julia M. Amadio , Peter H. R. Persicaner , Janice Louise Cacace , Neda Irani , Frederick D. Sancilio
CPC分类号： A61K31/57 , A61K9/1075 , A61K9/16 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/7023 , A61K31/565 , A61K47/10 , A61K47/14 , A61K2300/00
摘要： Hormone replacement therapies are provided comprising solubilized progesterone alone and optionally with an estrogen, cyclic/sequential and continuous-combined dosing, and administered via transdermal HRT delivery systems.
摘要翻译： 提供激素替代疗法，其包括单独的溶解的孕酮和任选的雌激素，循环/顺序和连续组合给药，并通过经皮HRT递送系统施用。
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公开(公告)号：US20150202211A1
公开(公告)日：2015-07-23
申请号：US14671651
申请日：2015-03-27
申请人： TherapeuticsMD, Inc.
发明人： Julia Amadio , Brian Bernick
IPC分类号： A61K31/57
CPC分类号： A61K31/57 , A61K9/4825 , A61K9/4858 , A61K47/14
摘要： This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.
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公开(公告)号：US20140100204A1
公开(公告)日：2014-04-10
申请号：US14099598
申请日：2013-12-06
申请人： TherapeuticsMD, Inc.
IPC分类号： A61K31/57 , A61K31/565
CPC分类号： A61K31/57 , A61K9/0034 , A61K9/02 , A61K9/1075 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/565 , A61K47/10 , A61K47/14 , A61K47/44 , A61K2300/00
摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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公开(公告)号：US20230218636A1
公开(公告)日：2023-07-13
申请号：US18053120
申请日：2022-11-07
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Janice Louise CACACE , Peter H.R. PERSICANER , Neda IRANI , Julia M. AMADIO , Frederick D. SANCILIO
IPC分类号： A61K31/57 , A61K9/48 , A61K9/107 , A61K31/565 , A61K47/10 , A61K47/14 , A61K9/00 , A61K47/44 , A61K9/02
CPC分类号： A61K31/57 , A61K9/02 , A61K9/0034 , A61K9/48 , A61K9/1075 , A61K9/4858 , A61K9/4866 , A61K31/565 , A61K47/10 , A61K47/14 , A61K47/44
摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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公开(公告)号：US20230210765A1
公开(公告)日：2023-07-06
申请号：US18046101
申请日：2022-10-12
申请人： TherapeuticsMD, Inc.
IPC分类号： A61K9/00 , A61K31/565 , A61K9/48
CPC分类号： A61K9/0036 , A61K31/565 , A61K9/4858 , A61K47/14
摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：US11633405B2
公开(公告)日：2023-04-25
申请号：US17169103
申请日：2021-02-05
申请人： TherapeuticsMD, Inc.
发明人： Veeran Gowda Kadajji , Mafruhul Bari , Annette Shadiack , Thorsteinn Thorsteinsson , Peter H. R. Persicaner
IPC分类号： A61K31/565 , A61K9/00 , A61K9/48
摘要： This disclosure provides pharmaceutical compositions for delivering estradiol to a subject in need thereof, as well as methods of administering the compositions, and methods of using them.
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公开(公告)号：US20230062295A1
公开(公告)日：2023-03-02
申请号：US17705752
申请日：2022-03-28
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Thorsteinn THORSTEINSSON , Peter H.R. PERSICANER , Janice Louise CACACE , Frederick D. SANCILIO , Neda IRANI , Julia AMADIO
IPC分类号： A61K31/565 , A61K9/00 , A61K31/57 , A61K47/14
摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：US11529360B2
公开(公告)日：2022-12-20
申请号：US16520167
申请日：2019-07-23
申请人： TherapeuticsMD, Inc.
发明人： Brian A. Bernick , Janice Louise Cacace , Peter H. R. Persicaner , Neda Irani , Julia M. Amadio , Frederick D. Sancilio
IPC分类号： A61K9/48 , A61K31/57 , A61K47/14 , A61K31/565 , A61K47/44 , A61K9/02 , A61P15/00 , A61K47/10 , A61K9/107 , A61K9/00
摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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公开(公告)号：US11110099B2
公开(公告)日：2021-09-07
申请号：US16885066
申请日：2020-05-27
申请人： TherapeuticsMD, Inc.
发明人： Brian A. Bernick , Janice Louise Cacace , Peter H. R. Persicaner , Neda Irani , Julia M. Amadio
IPC分类号： A61K31/57 , A61K31/565 , A61K9/48 , A61K47/14 , A61K47/44 , A61K47/10 , A61K9/107 , A61K9/00 , A61K9/02
摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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