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公开(公告)号：US20200297735A1
公开(公告)日：2020-09-24
申请号：US16833186
申请日：2020-03-27
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Thorsteinn THORSTEINSSON , Peter H.R. PERSICANER , Janice Louise CACACE , Frederick D. SANCILIO , Neda IRANI , Julia AMADIO
IPC分类号： A61K31/565 , A61K9/00 , A61K31/57 , A61K47/14
摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：US20170281776A1
公开(公告)日：2017-10-05
申请号：US15473742
申请日：2017-03-30
申请人： TherapeuticsMD, Inc.
发明人： Annette SHADIACK , Peter H.R. PERSICANER , Philip B. INSKEEP , Thorsteinn THORSTEINSSON , Frederick D. SANCILIO , Jason D. LEGASSIE
CPC分类号： A61K47/26 , A61K9/0053 , A61K9/145 , A61K31/57 , A61K47/14
摘要： This disclosure provides a novel pharmaceutical composition capable of forming micelles upon exposure to the gastric environment. The pharmaceutical composition is suitable for delivering steroid hormones, and progesterone in particular, to a subject in need thereof
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公开(公告)号：US20230218636A1
公开(公告)日：2023-07-13
申请号：US18053120
申请日：2022-11-07
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Janice Louise CACACE , Peter H.R. PERSICANER , Neda IRANI , Julia M. AMADIO , Frederick D. SANCILIO
IPC分类号： A61K31/57 , A61K9/48 , A61K9/107 , A61K31/565 , A61K47/10 , A61K47/14 , A61K9/00 , A61K47/44 , A61K9/02
CPC分类号： A61K31/57 , A61K9/02 , A61K9/0034 , A61K9/48 , A61K9/1075 , A61K9/4858 , A61K9/4866 , A61K31/565 , A61K47/10 , A61K47/14 , A61K47/44
摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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公开(公告)号：US20230062295A1
公开(公告)日：2023-03-02
申请号：US17705752
申请日：2022-03-28
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Thorsteinn THORSTEINSSON , Peter H.R. PERSICANER , Janice Louise CACACE , Frederick D. SANCILIO , Neda IRANI , Julia AMADIO
IPC分类号： A61K31/565 , A61K9/00 , A61K31/57 , A61K47/14
摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：US20200230153A1
公开(公告)日：2020-07-23
申请号：US16837933
申请日：2020-04-01
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Julia M. AMADIO , Peter H.R. PERSICANER , Thorsteinn THORSTEINSSON , Janice Louise CACACE , Frederick D. SANCILIO , Neda IRANI
IPC分类号： A61K31/57 , A61K31/565 , A61K47/44 , A61K47/10 , A61K47/14 , A61K9/107 , A61K9/48 , A61K9/00 , A61K9/02
摘要： According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：US20180280411A1
公开(公告)日：2018-10-04
申请号：US15901467
申请日：2018-02-21
申请人： TherapeuticsMD, Inc.
发明人： Annette SHADIACK , Peter H.R. PERSICANER , Philip B. INSKEEP , Thorsteinn THORSTEINSSON , Frederick D. SANCILIO , Jason D. LEGASSIE
摘要： This disclosure provides a novel pharmaceutical composition for delivering steroid hormones to a patient in need thereof.
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公开(公告)号：US20200297736A1
公开(公告)日：2020-09-24
申请号：US16833188
申请日：2020-03-27
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Thorsteinn THORSTEINSSON , Peter H.R. PERSICANER , Janice Louise CACACE , Frederick D. SANCILIO , Neda IRANI , Julia AMADIO
IPC分类号： A61K31/565 , A61K9/00 , A61K31/57 , A61K47/14
摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：US20200276210A1
公开(公告)日：2020-09-03
申请号：US16875030
申请日：2020-05-15
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Julia M. AMADIO , Peter H.R. PERSICANER , Thorsteinn THORSTEINSSON , Janice Louise CACACE , Frederick D. SANCILIO , Neda IRANI
IPC分类号： A61K31/57 , A61K31/565 , A61K47/44 , A61K47/10 , A61K47/14 , A61K9/107 , A61K9/48 , A61K9/00 , A61K9/02
摘要： According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy
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公开(公告)号：US20170281645A1
公开(公告)日：2017-10-05
申请号：US15473733
申请日：2017-03-30
申请人： TherapeuticsMD, Inc.
发明人： Annette SHADIACK , Peter H.R. PERSICANER , Philip B. INSKEEP , Thorsteinn THORSTEINSSON , Frederick D. SANCILIO , Jason D. LEGASSIE
CPC分类号： A61K31/57 , A61K9/0053 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K47/06 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/44
摘要： This disclosure provides a novel pharmaceutical composition for delivering steroid hormones to a patient in need thereof.
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公开(公告)号：US20240350514A1
公开(公告)日：2024-10-24
申请号：US18485929
申请日：2023-10-12
申请人： TherapeuticsMD, Inc.
发明人： Brian A. BERNICK , Thorsteinn THORSTEINSSON , Peter H.R. PERSICANER , Janice Louise CACACE , Frederick D. SANCILIO , Neda IRANI , Julia AMADIO
IPC分类号： A61K31/565 , A61K9/00 , A61K31/57 , A61K47/14
CPC分类号： A61K31/565 , A61K9/0036 , A61K31/57 , A61K47/14
摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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