公开(公告)号：US06482809B1

公开(公告)日：2002-11-19

申请号：US09506031

申请日：2000-02-17

申请人： Thierry Bardon ,  Dominique Thibaud

发明人： Thierry Bardon ,  Dominique Thibaud

IPC分类号： A01N5700

CPC分类号： A61K31/663

摘要： The present invention relates to the use of an active substance selected from the group consisting of tiludronic acid, one of its pharmaceutically acceptable salts, one of its hydrates and mixtures thereof, in the preparation of a medicinal product for preventing and treating osteoporosis in poultry.

摘要翻译： 本发明涉及选自噻替膦酸，其药学上可接受的盐之一，其水合物之一及其混合物的活性物质在制备用于预防和治疗家禽骨质疏松症的药物中的用途。

公开(公告)号：US06455514B2

公开(公告)日：2002-09-24

申请号：US09192184

申请日：1998-11-16

申请人： Philippe Du Mesnil ,  Thierry Bardon ,  Dominique Thibaud

发明人： Philippe Du Mesnil ,  Thierry Bardon ,  Dominique Thibaud

IPC分类号： A01N5700

CPC分类号： A61K31/663 ,  A61K31/675

摘要： The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from arthritis or from fractures, of an effective amount of a bisphosphonic acid derivative of formula: in which: R1 represents a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono(C1-C4)alkylamino or a di(C1-C4)alkylamino; R2 represents a halogen atom, a linear alkyl comprising from 1 to 5 carbon atoms which is unsubstituted or substituted with a group chosen from a chlorine atom, a hydroxyl, an amino, a mono(C1-C4)alkylamino or a di(C1-C4)alkylamino; a (C3-C7) cycloalkylamino, or R2 represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridyl-methyl, a 1-pyridyl-1-hydroxymethyl, an imidazolyl-methyl or a 4-thiomorpholinyl, of one of its pharmaceutically acceptable salts or of one of its hydrates.

摘要翻译： 本发明涉及一种用骨，关节或骨关节成分治疗跛行的方法，其包括将有效量的下式的双膦酸衍生物给予人或不患有关节炎或骨折的动物：在 其中：R1表示氢原子，卤素原子，羟基，氨基，单（C1-C4）烷基氨基或二（C1-C4）烷基氨基; R2表示卤素原子，包括1至5个 未取代或被选自氯原子，羟基，氨基，单（C1-C4）烷基氨基或二（C1-C4）烷基氨基的基团取代的碳原子; （C 3 -C 7）环烷基氨基或R 2表示苯氧基，苯基，硫醇，苯硫基，氯苯硫基，吡啶基，吡啶基 - 甲基，1-吡啶基-1-羟甲基，咪唑基甲基或4 - 硫代吗啉基，其药学上可接受的盐之一或其水合物之一。

公开(公告)号：US06432930B1

公开(公告)日：2002-08-13

申请号：US09757197

申请日：2001-01-09

申请人： Leo A. Renello ,  Joseph Synek

发明人： Leo A. Renello ,  Joseph Synek

IPC分类号： A01N5700

摘要： An improved termiticidal combination is formed by adding a liquid cellulose source to a standard liquid termiticide. The cellulose source may be a water soluble polyester such as a cellulose ether like methyl cellulose. The cellulose in the combination functions as termite bait, thereby enhancing the effectiveness of the poison, even at lower concentrations, by inducing termites to ingest poisoned cellulose and return with it to share it with the colony. The liquid form allows the combination to be applied with a standard power sprayer, and permits laying of a continuous barrier or curtain as well as injection spraying into walls of structures.

公开(公告)号：US06365550B1

公开(公告)日：2002-04-02

申请号：US09619997

申请日：2000-07-20

申请人： Dieter Feucht ,  Mark-Wilhelm Drewes ,  Peter Dahmen ,  Rolf Pontzen

发明人： Dieter Feucht ,  Mark-Wilhelm Drewes ,  Peter Dahmen ,  Rolf Pontzen

IPC分类号： A01N5700

CPC分类号： A01N57/20 ,  A01N43/82 ,  A01N2300/00

摘要： The invention relates to synergistic herbicidal compositions comprising a combination of (a) flufenacet (N-(4-fluoro-phenyl)-N-(i-propyl)-2-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl-oxy)-acetamide), of the formula (I), and (b) glyphosate (N-phosphonomethyl-glycine) or its esters which are described in the description and/or salts of glyphosate and its esters which are formed with basic compounds and/or (c) glufosinate (2-amino-4-(hydroxy-methyl-phosphinyl)-butanoic acid) and/or the salts of glufosinate which are formed with basic compounds, where 0.01 to 100 parts by weight of glyphosate and/or its salts or its esters and/or their salts, or of glufosinate and/or its salts, are used per part by weight of flufenacet.

摘要翻译： 本发明涉及协同除草组合物，其包含（a）氟芬酸（N-（4-氟 - 苯基）-N-（异丙基）-2-（5-三氟甲基-1,3,4-噻二唑-2-基） - 酰氧基） - 乙酰胺），和（b）草甘膦（N-膦酰基甲基 - 甘氨酸）或其酯，其描述和/或草甘膦及其酯形成的盐与 碱性化合物和/或（c）草铵膦（2-氨基-4-（羟基 - 甲基 - 氧膦基） - 丁酸）和/或与碱性化合物形成的草铵膦的盐，其中0.01至100重量份的草甘膦 和/或其盐或其酯和/或其盐，或草铵膦和/或其盐，按重量份的flufenacet使用。

公开(公告)号：US06172049B2

公开(公告)日：2001-01-09

申请号：US09326840

申请日：1999-06-07

申请人： Brian Patrick Dwyer ,  Alexandre V. Lehedev ,  Bob Dale Brown ,  David Aaron Schwartz

发明人： Brian Patrick Dwyer ,  Alexandre V. Lehedev ,  Bob Dale Brown ,  David Aaron Schwartz

IPC分类号： A01N5700

CPC分类号： C07F9/4075 ,  A61K9/1272 ,  A61K31/575 ,  A61K31/66 ,  A61K31/70 ,  A61K45/06 ,  A61K47/24 ,  A61K47/54 ,  A61K47/543 ,  A61K47/548 ,  C07J51/00 ,  A61K2300/00

摘要： The present invention provides novel phosphonic acid-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) R3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X− is an anion or polyanion; (f) Y is N or 0, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.

摘要翻译： 本发明提供了一般结构的新型基于膦酸的阳离子脂质：或其盐或溶剂合物或其对映体，其中： （a）R 1是亲脂性部分; （b）R2是带正电的部分; （c）R3是1至约24个碳原子的亲油部分，带正电荷的部分或带负电荷的部分; （d）n为0〜8的整数， （e）X-是阴离子或聚阴离子; （f）Y为N或0，（g）m为0至等于脂质上存在的正电荷数的整数。本发明还提供了这些脂质与聚阴离子大分子的组合物， 干扰利用这些组合物的细胞中的蛋白质表达和用于制备它们的试剂盒。