公开(公告)号：US20030099763A1

公开(公告)日：2003-05-29

申请号：US10158582

申请日：2002-05-30

Applicant: The Ohio State University

Inventor： Kenneth H. Sandhage

IPC: B05D003/00 ,  B01J013/00 ,  A61J001/00

CPC classification number: G01N33/54346 ,  B81B2201/034 ,  B81B2201/035 ,  B81C1/00 ,  B81C99/0085 ,  G01N33/54353 ,  G01N33/544 ,  Y10S977/811 ,  Y10S977/84 ,  Y10S977/89 ,  Y10S977/90

Abstract: The present invention is focused on a revolutionary, low-cost (highly-scaleable) approach for the mass production of three-dimensional microcomponents: the biological reproduction of naturally-derived, biocatalytically-derived, and/or genetically-tailored three-dimensional microtemplates (e.g., frustules of diatoms, microskeletons of radiolarians, shells of mollusks) with desired dimensional features, followed by reactive conversion of such microtemplates into microcomponents with desired compositions that differ from the starting microtemplate and with dimensional features that are similar to those of the starting microtemplate. Because the shapes of such microcomponents may be tailored through genetic engineering of the shapes of the microtemplates, such microcomposites are considered to be Genetically-Engineered Materials (GEMs).

Abstract translation: 本发明集中在用于大规模生产三维微型组件的革命性的低成本（高度可扩展）方法：天然衍生的，生物催化衍生的和/或基因定制的三维微型模板的生物繁殖 （例如，硅藻的截头圆锥体，放射体的微骨架，软体动物的壳）具有所需的尺寸特征，随后将这种微模板反应转化成具有与起始微模板不同的所需组成的微组件，并具有与起始微模板类似的尺寸特征 微模板。 由于这些微型组件的形状可以通过微型模板的形状的遗传工程来定制，所以这种微复合材料被认为是基因工程材料（GEM）。

公开(公告)号：US20030049324A1

公开(公告)日：2003-03-13

申请号：US10174682

申请日：2002-06-19

Applicant: Heraeus Kulzer GmbH & Co. KG

Inventor： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus-Dieter Kuhn

IPC: A61K031/704 ,  A61J001/00 ,  B01J013/00 ,  A61K031/70 ,  A61K031/4709 ,  A61K031/496 ,  A61K031/65 ,  A61K009/16 ,  A61K009/50

CPC classification number: A61K9/0024

Abstract: The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in that in the microcavities of non-metallic bodies an aqueous solution 1, which contains at least one easily water-soluble antibiotic component from the groups of the aminoglycoside antibiotics, the tetracycline antibiotics, the lincosamide antibiotics and the 4-quinolone antibiotics, and an aqueous solution 2, which contains at least one easily water-soluble amphiphilic component from the groups of the alkyl sulfates, alkyl sulfonates, alkylaryl sulfates, dialkylaryl sulfates, alkylaryl sulfonates, dialkylaryl sulfonates, cycloalkyl sulfates, cycloalkyl sulfonates, alkylcycloalkyl sulfates, are introduced, wherein between the introduction of solutions 1 and 2 the water is basically removed through vaporization and/or evaporation, and whereby from the components of solutions 1 and 2 in the microcavities a deposit is formed, which is sparingly soluble in water.

Abstract translation: 本发明涉及一种用于具有互连微腔的物体的抗生素包被的方法以及这种方式涂覆的物体及其用途。 本发明的方法的特征在于，在非金属体的微腔中，含有来自氨基糖苷类抗生素组的至少一种容易水溶性抗生素成分的水溶液1，四环素抗生素，氯胺素抗生素和4- 喹诺酮抗生素和水溶液2，其含有至少一种容易水溶性的两亲成分，分别为烷基硫酸盐，烷基磺酸盐，烷基芳基硫酸盐，二烷基芳基硫酸盐，烷基芳基磺酸盐，二烷基芳基磺酸盐，环烷基硫酸盐，环烷基磺酸盐，烷基环烷基 硫酸盐，其中在引入溶液1和2之间基本上通过蒸发和/或蒸发除去水，并且由此在微腔中的溶液1和2的组分中形成沉积物，其沉积物微溶于水 。

公开(公告)号：US20020197319A1

公开(公告)日：2002-12-26

申请号：US10209463

申请日：2002-07-31

Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.

Inventor： Michael L. Cappola

IPC: A61K009/32 ,  B01J013/00

CPC classification number: A61K9/2886 ,  A61K9/2072

Abstract: The invention provides a process for coating a branded pharmaceutical dosage form for the purpose of covering any embossed or printed matter or any colored coating by the application of an amount of a sugar based coating which is sufficient to obscure any identifying indicia without compromising the stability or releasability of the drug that is contained in the dosage form.

Abstract translation: 本发明提供了一种涂覆品牌药物剂型的方法，其目的是通过施加一定量的糖基涂层来覆盖任何压花或印刷物或任何着色涂层，其足以掩盖任何识别标记而不损害稳定性或 包含在剂型中的药物的释放性。

公开(公告)号：US20020197207A1

公开(公告)日：2002-12-26

申请号：US10173492

申请日：2002-06-17

Inventor： Andrew John Ruys ,  Bruce Nathaniel Gray

IPC: A61K051/00 ,  B01J013/00 ,  A61L002/00

CPC classification number: A61K51/1255

Abstract: This invention relates to a particulate material comprising an inorganic low density, radiation tolerant core coated with a radionuclide, processes for its production and a method of radiation therapy utilising the particulate material.

Abstract translation: 本发明涉及一种颗粒材料，其包括涂覆有放射性核素的无机低密度耐辐射芯，其生产方法和使用该颗粒材料的放射治疗方法。

公开(公告)号：US20020037360A1

公开(公告)日：2002-03-28

申请号：US09902049

申请日：2001-07-10

Applicant: The Procter & Gamble Company

Inventor： Angelina Pena-Romero ,  Eric Temmerman ,  Walter Franciscus Joanna Vanderveken

IPC: A61J001/00 ,  B01J013/00 ,  C11D017/06

CPC classification number: C11D17/0082 ,  C07C51/50 ,  C11D3/2082 ,  C07C55/02 ,  C07C55/14

Abstract: According to the present invention there is provided a process for retarding the discolouration of dicarboxylic acids, said process comprising heating said dicarboxylic acid to a temperature above its melting point and adding at least one metal ion sequesterant to said dicarboxylic acid. A further aspect of the present invention provides a composition comprising at least one dicarboxylic acid and at least one metal ion sequesterant. A further aspect of the present invention provides for the use of metal ion sequesterants to retard the discolouration of dicarboxylic acids, particularly molten dicarboxylic acids.

Abstract translation: 根据本发明，提供了一种延缓二羧酸变色的方法，所述方法包括将所述二羧酸加热至高于其熔点的温度，并向所述二羧酸加入至少一种金属离子螯合剂。 本发明的另一方面提供了包含至少一种二羧酸和至少一种金属离子螯合剂的组合物。 本发明的另一方面提供了金属离子螯合剂用于延缓二羧酸，特别是熔融二羧酸变色的用途。