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公开(公告)号：US11679157B2
公开(公告)日：2023-06-20
申请号：US17008495
申请日：2020-08-31
发明人： Susan R. Mallery , Peter E. Larsen , Gary D. Stoner , Steven P. Schwendeman , Kashappa-Goud Desai
CPC分类号： A61K47/10 , A61K9/006 , A61K9/0056 , A61K9/7007 , A61K31/07 , A61K47/24 , A61K47/28 , A61K47/32
摘要： Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
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公开(公告)号：US11193913B2
公开(公告)日：2021-12-07
申请号：US16778791
申请日：2020-01-31
摘要： A method of detecting sub-surface voids in a sample comprises positioning a probe adjacent to a first point on the sample, emitting an ultrasonic wave from the probe towards the sample, moving the probe towards the sample, measuring a shear force amplitude of a reflection of the ultrasonic wave at the probe as the probe moves towards the sample, creating an approach curve by plotting the measured shear force amplitude of the reflection of the ultrasonic wave as a function of a distance between the probe and the sample, and determining whether a sub-surface void exists at the first point on the sample based on a slope of the approach curve.
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公开(公告)号：US20210277368A1
公开(公告)日：2021-09-09
申请号：US16783383
申请日：2020-02-06
摘要： Disclosed herein are proteins having at least 90% sequence identity to a wild-type human butyrylcholinesterase and compositions comprising same. The disclosed proteins may have at least one mutation at a position within the acyl binding pocket and at least one mutation adjacent to the acyl biding pocket. Further disclosed are proteins having at least 90% sequence identity to a wild-type human butyrylcholinesterase, wherein the protein may comprise a mutation at a position selected from one or more of 282, 283, and 284.
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公开(公告)号：US20210239653A1
公开(公告)日：2021-08-05
申请号：US16778791
申请日：2020-01-31
摘要： A method of detecting sub-surface voids in a sample comprises positioning a probe adjacent to a first point on the sample, emitting an ultrasonic wave from the probe towards the sample, moving the probe towards the sample, measuring a shear force amplitude of a reflection of the ultrasonic wave at the probe as the probe moves towards the sample, creating an approach curve by plotting the measured shear force amplitude of the reflection of the ultrasonic wave as a function of a distance between the probe and the sample, and determining whether a sub-surface void exists at the first point on the sample based on a slope of the approach curve.
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公开(公告)号：US10925697B2
公开(公告)日：2021-02-23
申请号：US15781134
申请日：2016-12-13
发明人： Jung-Suk Han , Do-Gyoon Kim
IPC分类号： A61C8/00 , A61C8/02 , A61C19/06 , A61C13/225
摘要： The present invention relates to an integrated hybrid dental implant, and more particularly, to an integrated hybrid dental implant in which an opening portion formed at a screw body to enable a drug to be injected into an implantation site of the implant, and the mechanical stability is excellent despite the presence of the opening portion. The integrated hybrid dental implant according to the present invention enables a drug to be supplied to the area around the implantation site so as to induce bone regeneration into the implant after the implant has been placed at a bone-deficient site, has an additional mechanical strength when bone grows into the side openings and hollow inner channel, and allows the screw body to be integrally formed with the prosthesis section (i.e., one piece) to exhibit more excellent mechanical strength so that the implant can be useful as a dental implant.
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公开(公告)号：US10478488B2
公开(公告)日：2019-11-19
申请号：US15723793
申请日：2017-10-03
发明人： Xingguo Cheng , Kenneth H. Carson , Joseph A. McDonough , Renukaradhya J. Gourapura , Chang Won Lee , Santosh Dhakal
IPC分类号： A61K39/12 , A61K39/145 , A61K39/00
摘要： The present invention relates to the field of pharmaceutical and vaccine formulations. More specifically, formulations which comprise an antigen comprising a mixture of oligopeptides loaded into liposome nanoparticles, optionally including an adjuvant, to provide an improved immune response.
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公开(公告)号：US20190119353A1
公开(公告)日：2019-04-25
申请号：US15525013
申请日：2015-11-05
发明人： Xue-Feng BAI , Yang LIU , Pan ZHENG , Jin-Qing LIU
IPC分类号： C07K14/705 , C07K14/54 , A61K48/00 , A61K35/12 , A61K38/00
摘要： Chimeric fusion proteins and polynucleotides encoding the chimeric fusion proteins are provided for the treatment of proliferative disorders, automimmune diseases and alloimmune responses. The chimeric fusion proteins comprise a CD24 extracellular domain, an EBV-induced 3 (EBI3) polypeptide subunit, and a p28 IL-27 polypeptide subunit, wherein the EBB polypeptide and the p28 IL-27 polypeptide subunit are covalently joined by a flexible peptide linker.
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公开(公告)号：US10081772B2
公开(公告)日：2018-09-25
申请号：US15191249
申请日：2016-06-23
发明人： Liang-Shih Fan , Fanxing Li
IPC分类号： B01J19/00 , B01J19/24 , C01B3/02 , C01B3/34 , C10J3/12 , C10J3/46 , C10J3/48 , C10J3/72 , F23C99/00
CPC分类号： C10J3/725 , B01J19/245 , B01J2219/19 , B01J2219/24 , C01B3/02 , C01B3/344 , C10J3/12 , C10J3/463 , C10J3/485 , C10J2300/0916 , C10J2300/093 , C10J2300/0943 , C10J2300/0959 , C10J2300/0969 , C10J2300/0976 , C10J2300/1671 , C10J2300/1807 , C10J2300/1869 , C10J2300/1884 , F23C99/00 , F23C2900/99008 , Y02E20/16 , Y02E20/346 , Y02P20/52 , Y10T428/2982
摘要： A system for converting fuel is provided and includes a first reactor comprising a plurality of ceramic composite particles, the ceramic composite particles comprising at least one metal oxide disposed on a support, wherein the first reactor is configured to reduce the at least one metal oxide with a fuel to produce a reduced metal or a reduced metal oxide; a second and reactor configured to oxidize at least a portion of the reduced metal or reduced metal oxide from the said first reactor to produce a metal oxide intermediate; a source of air; and a third reactor communicating with said source of air and configured to regenerate the at least one metal oxide from the remaining portion of the solids discharged from the said first reactor and the solids discharged from the said second reactor for by oxidizing the metal oxide intermediate.
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公开(公告)号：US10048261B2
公开(公告)日：2018-08-14
申请号：US15404681
申请日：2017-01-12
发明人： Subinoy Das , Lauren O. Bakaletz
IPC分类号： A61K39/102 , A61K39/02 , A61K39/40 , G01N33/569 , C12Q1/04 , A61B10/00
摘要： The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.
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公开(公告)号：US09861690B2
公开(公告)日：2018-01-09
申请号：US15174643
申请日：2016-06-06
发明人： Yasuko Rikihisa
IPC分类号： A61K39/02 , A61K38/04 , G01N33/53 , C07K14/29 , C07K7/08 , G01N33/569 , G01N33/68 , A61K38/00 , A61K39/00
CPC分类号： A61K39/0233 , A61K38/00 , A61K38/04 , A61K2039/552 , A61K2039/575 , A61K2039/6031 , C07K7/08 , C07K14/29 , G01N33/53 , G01N33/56911 , G01N33/6854 , G01N2333/29 , G01N2469/20 , Y02A50/402
摘要： The novel omp-1 gene cluster encoding twenty one Ehrlichia ewingii (EE) proteins was isolated and sequenced completely. This invention relates to isolated E. ewinigii (EE) polypeptides, isolated polynucleotides encoding EE polypeptides, probes, primers, isolated antibodies and methods of their production, immunogenic compositions and vaccines, as well as methods of using the EE polypeptides, antibodies, probes, and primers for the purpose of diagnosis, therapy and production of vaccines against E. ewingii.
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