Methods, devices, and systems related to analyte monitoring

    公开(公告)号:US11633127B2

    公开(公告)日:2023-04-25

    申请号:US16950595

    申请日:2020-11-17

    摘要: Generally, methods, devices, and systems related to analyte monitoring and data logging are provided—e.g., as related to in vivo analyte monitoring devices and systems. In some aspects, methods, devices, and systems are provided that relate to enable related settings based on an expected use of an in vivo positioned sensor; logging or otherwise recording analyte levels acquired or derived—e.g., sample analyte levels more frequently than they are logged or otherwise recorded in memory; dynamically adjust the data logging frequency; randomly determine times of acquiring or storing analyte levels from the in-vivo positioned analyte sensors; and enable recording related settings when the system is operable.

    ANALYTE SENSORS AND SENSING METHODS FEATURING DUAL DETECTION OF GLUCOSE AND KETONES

    公开(公告)号:US20230121101A1

    公开(公告)日:2023-04-20

    申请号:US18068807

    申请日:2022-12-20

    摘要: Glucose and ketones may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using an analyte sensor capable of detecting both analytes. Certain analyte sensors capable of dual detection may comprise a first working electrode and a second working electrode, a ketones-responsive active area disposed upon a surface of the first working electrode, a glucose-responsive active area comprising a glucose-responsive enzyme disposed upon a surface of the second working electrode, a membrane having a first portion overcoating the ketones-responsive active area and a second portion overcoating the glucose-responsive active area, in which the first portion and the second portion have different compositions. The ketones-responsive active area comprises an enzyme system comprising at least two enzymes that are capable of acting in concert to facilitate detection of ketones.

    ANALYTE SENSORS AND SENSING METHODS FEATURING DUAL DETECTION OF GLUCOSE AND KETONES

    公开(公告)号:US20230119512A1

    公开(公告)日:2023-04-20

    申请号:US18068860

    申请日:2022-12-20

    摘要: Glucose and ketones may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using an analyte sensor capable of detecting both analytes. Certain analyte sensors capable of dual detection may comprise a first working electrode and a second working electrode, a ketones-responsive active area disposed upon a surface of the first working electrode, a glucose-responsive active area comprising a glucose-responsive enzyme disposed upon a surface of the second working electrode, a membrane having a first portion overcoating the ketones-responsive active area and a second portion overcoating the glucose-responsive active area, in which the first portion and the second portion have different compositions. The ketones-responsive active area comprises an enzyme system comprising at least two enzymes that are capable of acting in concert to facilitate detection of ketones.

    ADAPTIVE SENSOR SENSITIVITY FOR ANALYTE MONITORING SYSTEMS

    公开(公告)号:US20230099851A1

    公开(公告)日:2023-03-30

    申请号:US17953966

    申请日:2022-09-27

    IPC分类号: A61B5/145

    摘要: Embodiments described herein include a device and a computer program product. The device includes one or more processors, an analyte sensor, a temperature sensor, a communication module, and memories. The processors are configured to generate external temperature of the analyte sensor measured by the temperature sensor corresponding to a first time, to calculate a sensitivity adjustment of the senor based on the temperature data, to add the sensitivity adjustment corresponding to the first time to a total sensitivity adjustment, and to determine whether the first time is below a predetermined time threshold, and if so, to generate external temperature data corresponding to a second time and to calculate an interval between the second time and the first time. The processors are further configured to determine if the first time is equal to the predetermined time threshold, and if so, to store the total sensitivity adjustment in an OTP memory.

    METHODS, DEVICES, AND SYSTEMS FOR ADJUSTING LABORATORY HBA1C VALUES

    公开(公告)号:US20230061350A1

    公开(公告)日:2023-03-02

    申请号:US17779370

    申请日:2020-11-24

    摘要: Physiological parameters that related to the kinetics of red blood cell hemoglobin glycation, red blood cell elimination, and red blood cell generation within the body of a subject can be used, for example, to calculate a more reliable calculated HbA1c (cHbA1c), adjusted HbA1c (aHbA1c), and/or a personalized target glucose range, among other things, for subject-personalized diagnoses, treatments, and/or monitoring protocols. Such physiological parameters may be determined using a model that considers cross-membrane glucose transport and glycation.