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41.发明申请公开(公告)号：US20200085501A1
公开(公告)日：2020-03-19
申请号：US16691134
申请日：2019-11-21
申请人： HeartFlow, Inc.
发明人： Sethuraman Sankaran , Charles A. Taylor , Gilwoo Choi , Michiel Schaap , Christopher K. Zarins , Leo Grady
IPC分类号： A61B34/10 , G16B45/00 , A61B6/00 , A61B5/02 , A61B5/00 , A61B6/03 , G16H50/30 , G16H50/50 , G16H50/20
摘要： Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model.
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42.发明授权公开(公告)号：US10575810B2
公开(公告)日：2020-03-03
申请号：US15459835
申请日：2017-03-15
申请人： HeartFlow, Inc.
发明人： Sethuraman Sankaran , Michiel Schaap , Leo Grady
摘要： Systems and methods are disclosed for predicting healthy lumen radius and calculating a vessel lumen narrowing score. One method of identifying a lumen diameter of a patient's vasculature includes: receiving a data set including one or more lumen segmentations of known healthy vessel segments of a plurality of individuals; extracting one or more lumen features for each of the vessel segments; receiving a lumen segmentation of a patient's vasculature; determining a section of the patient's vasculature; and determining a healthy lumen diameter of the section of the patient's vasculature using the extracted one or more features for each of the known healthy vessel segments of the plurality of individuals.
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公开(公告)号：US10572998B2
公开(公告)日：2020-02-25
申请号：US15680728
申请日：2017-08-18
申请人： HeartFlow, Inc.
IPC分类号： G16H40/63 , G06T7/00 , G16H50/20 , G06F19/00 , A61B6/00 , G06K9/46 , G06K9/62 , G06T5/00 , A61B6/03 , G16H50/70
摘要： Systems and methods are disclosed for identifying image acquisition parameters. One method includes receiving a patient data set including one or more reconstructions, one or more preliminary scans or patient information, and one or more acquisition parameters; computing one or more patient characteristics based on one or both of one or more preliminary scans and the patient information; computing one or more image characteristics associated with the one or more reconstructions; grouping the patient data set with one or more other patient data sets using the one or more patient characteristics; and identifying one or more image acquisition parameters suitable for the patient data set using the one or more image characteristics, the grouping of the patient data set with one or more other patient data sets, or a combination thereof.
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公开(公告)号：US10561324B2
公开(公告)日：2020-02-18
申请号：US15624424
申请日：2017-06-15
申请人： HeartFlow, Inc.
发明人： Timothy Fonte , Gilwoo Choi , Leo Grady , Michael Singer
IPC分类号： A61B5/026 , G06N20/00 , A61B6/00 , G16H50/20 , A61B5/02 , A61B5/0205 , A61B5/021 , A61B5/107 , A61B5/00 , A61B6/03 , A61B5/145 , G06N7/00 , A61B5/024
摘要： Systems and methods are disclosed for determining individual-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, individual-specific anatomic data and blood flow characteristics of at least part of the individual's vascular system; executing a machine learning algorithm on the individual-specific anatomic data and blood flow characteristics for each of the plurality of individuals; relating, based on the executed machine learning algorithm, each individual's individual-specific anatomic data to functional estimates of blood flow characteristics; acquiring, for an individual and individual-specific anatomic data of at least part of the individual's vascular system; and for at least one point in the individual's individual-specific anatomic data, determining a blood flow characteristic of the individual, using relations from the step of relating individual-specific anatomic data to functional estimates of blood flow characteristics.
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45.发明授权公开(公告)号：US10553317B2
公开(公告)日：2020-02-04
申请号：US15827725
申请日：2017-11-30
申请人： HeartFlow, Inc.
摘要： Systems and methods are disclosed for determining a patient risk assessment or treatment plan based on emboli dislodgement and destination. One method includes receiving a patient-specific anatomic model generated from patient-specific imaging of at least a portion of a patient's vasculature; determining or receiving a location of interest in the patient-specific anatomic model of the patient's vasculature; using a computing processor for calculating blood flow through the patient-specific anatomic model to determine blood flow characteristics through at least the portion of the patient's vasculature of the patient-specific anatomic model downstream from the location of interest; and using a computing processor for particle tracking through the simulated blood flow to determine a destination probability of an embolus originating from the location of interest in the patient-specific anatomic model, based on the determined blood flow characteristics.
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公开(公告)号：US10546403B2
公开(公告)日：2020-01-28
申请号：US15834488
申请日：2017-12-07
申请人： HeartFlow, Inc.
发明人： Leo Grady , Michiel Schaap
摘要： Systems and methods are disclosed for controlling image annotation. One method includes acquiring a digital representation of image data and generating a set of image annotations for the digital representation of the image data. The method also may include determining an association between members of the set of image annotations and generating one or more groups of members based on the association. A representative annotation from the one or more groups may also be determined, presented for selection, and the selection may be recorded in memory.
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47.发明申请公开(公告)号：US20190336084A1
公开(公告)日：2019-11-07
申请号：US16514664
申请日：2019-07-17
申请人： HeartFlow, Inc.
发明人： Leo GRADY , Gilwoo CHOI , Michael SINGER
摘要： Systems and methods are disclosed for estimating patient-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, a geometric model and estimated blood flow characteristics of at least part of the individual's vascular system; executing a machine learning algorithm on the geometric model and estimated blood flow characteristics for each of the plurality of individuals; identifying, using the machine learning algorithm, features predictive of blood flow characteristics corresponding to a plurality of points in the geometric models; acquiring, for a patient, a geometric model of at least part of the patient's vascular system; and using the identified features to produce estimates of the patient's blood flow characteristic for each of a plurality of points in the patient's geometric model.
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48.发明授权公开(公告)号：US10413432B2
公开(公告)日：2019-09-17
申请号：US14887849
申请日：2015-10-20
申请人： HeartFlow, Inc.
发明人： Leo J. Grady , Charles A. Taylor , Gilwoo Choi , Campbell Rogers
IPC分类号： G06G7/58 , A61F2/95 , G16H50/50 , G16H50/20 , A61B6/00 , G06K9/62 , G06T7/00 , A61B34/10 , A61F2/30 , G06F17/50 , A61B90/00
摘要： Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring a geometric model of at least a portion of a patient's vascular system; obtaining one or more geometric quantities of one or more blood vessels of the geometric model of the patient's vascular system; determining the presence or absence of a pathology characteristic at a location in the geometric model of the patient's vascular system; generating an objective function defined by a plurality of device variables and a plurality of hemodynamic and solid mechanics characteristics; and optimizing the objective function using computational fluid dynamics and structural mechanics analysis to identify a plurality of device variables that result in desired hemodynamic and solid mechanics characteristics.
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公开(公告)号：US10314654B2
公开(公告)日：2019-06-11
申请号：US15054622
申请日：2016-02-26
申请人： HeartFlow, Inc.
摘要： Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.
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50.发明授权公开(公告)号：US10236084B2
公开(公告)日：2019-03-19
申请号：US15347592
申请日：2016-11-09
申请人： HeartFlow, Inc.
摘要： Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.
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