公开(公告)号：US20180000798A1

公开(公告)日：2018-01-04

申请号：US15436178

申请日：2017-02-17

Applicant: Almirall, S.A.

Inventor： Diana JARRETA FERNANDEZ ,  Maria Esther GARCIA GIL

IPC: A61K31/439 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/439 ,  A61K9/0075 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides aclidinium or any of its stereoisomers or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for improving the physical activity in respiratory patients.

公开(公告)号：US09737520B2

公开(公告)日：2017-08-22

申请号：US15161531

申请日：2016-05-23

Applicant: Almirall, S.A.

Inventor： Maria Esther Garcia Gil ,  Gonzalo De Miquel Serra ,  Maria Jose Sala Peinado

IPC: A61K31/439 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/439 ,  A61K9/0073 ,  A61K9/0075 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure provides aclidinium or any of its stereoisomers or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for improving the quality of sleep in respiratory patients.

公开(公告)号：US20170158699A1

公开(公告)日：2017-06-08

申请号：US15313762

申请日：2015-05-21

Applicant: Almirall, S.A.

Inventor： Francesc CARRERA CARRERA ,  Juan Bautista PEREZ GARCIA ,  Bernat VIDAL JUAN ,  Francisco SANCHEZ IZQUIEROD ,  Maria Carme SERRA COMA

IPC: C07D487/04 ,  A61K31/53 ,  C07C309/30 ,  C07C309/04 ,  C07C309/35

CPC classification number: A61K31/53 ,  A61K31/573 ,  A61K45/06 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/30 ,  C07C309/35 ,  C07D487/04

Abstract: The present invention is directed to novel pharmaceutically acceptable, addition salts of (S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile with sulfonic acid derivatives, in particular with methanesulfonic acid, naphthalene-2-sulfonic acid and para-toluenesulfonic acid, and pharmaceutically acceptable solvates thereof, and their use as Phosphoinositide 3-Kinase (PI3K) inhibitors.

公开(公告)号：US20170128426A1

公开(公告)日：2017-05-11

申请号：US15409741

申请日：2017-01-19

Applicant: Almirall, S.A.

Inventor： Rosa LAMARCA CASADO ,  Gonzalo DE MIQUEL SERRA

IPC: A61K31/439 ,  A61M15/00 ,  A61K31/167 ,  A61K47/26 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K31/439 ,  A61K9/0075 ,  A61K31/167 ,  A61K31/46 ,  A61K31/4706 ,  A61K31/573 ,  A61K45/06 ,  A61K47/26 ,  A61M11/00 ,  A61M15/00 ,  A61M15/0021 ,  A61M15/0038 ,  A61M15/0051 ,  A61M15/0086 ,  A61M2202/064 ,  F04C2270/0421 ,  A61K2300/00

Abstract: A pharmaceutical composition for inhalation comprising aclidinium in the form of a dry powder of a pharmaceutically acceptable salt in admixture with a pharmaceutically acceptable dry powder carrier, providing a delivered dose of aclidinium equivalent to about 322 micrograms aclidinium free base.

公开(公告)号：US09643961B2

公开(公告)日：2017-05-09

申请号：US15068926

申请日：2016-03-14

Applicant: Almirall, S.A.

Inventor： Maria Prat Quinones ,  Silvia Fonquerna Pou ,  Carlos Puig Duran ,  Wenceslao Lumeras Amador ,  Jose Aiguade Bosch ,  Juan Francisco Caturla Javaloyes

IPC: C07D215/26 ,  C07D409/14 ,  A61K31/4709 ,  C07D405/12 ,  C07D409/12 ,  C07D413/14

CPC classification number: C07D409/14 ,  A61K31/4709 ,  C07D215/26 ,  C07D405/12 ,  C07D409/12 ,  C07D413/14

Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

公开(公告)号：US20160200718A1

公开(公告)日：2016-07-14

申请号：US14956767

申请日：2015-12-02

Applicant: ALMIRALL, S.A.

Inventor： Jose AIGUADE BOSCH ,  Silvia GUAL ROIG ,  Maria PRAT QUINONES ,  Carlos PUIG DURAN

IPC: C07D417/14 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/538 ,  C07D409/12 ,  A61K31/4184 ,  A61K31/423 ,  C07D413/14 ,  C07D409/14

CPC classification number: A61K31/538 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4709 ,  A61K45/06 ,  C07D263/58 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

公开(公告)号：US20160166566A1

公开(公告)日：2016-06-16

申请号：US14906991

申请日：2014-07-24

Applicant: ALMIRALL, S.A.

Inventor： Montserrat JULIA JANE ,  Francesc CARRERA CARRERA ,  Maria PRAT QUIÑONES ,  Carlos PUIG DURAN ,  Francesca PAJUELO LORENZO ,  Juan Antonio PEREZ ANDRES

IPC: A61K31/4709 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K31/4709 ,  A61K9/0075 ,  A61K9/008 ,  A61K31/4725 ,  A61K45/06 ,  C07B2200/13 ,  C07C57/15 ,  C07D275/06 ,  C07D409/14 ,  C07D417/14 ,  A61K2300/00

Abstract: The present invention is directed to crystalline addition salts of (ii) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.

Abstract translation: 本发明涉及（ii）8-羟基喹啉-2（1H） - 酮衍生物和（ii）二羧酸或硫酰亚胺或其药学上可接受的溶剂合物的结晶加成盐。

公开(公告)号：US20160015704A1

公开(公告)日：2016-01-21

申请号：US14770200

申请日：2014-02-27

Applicant: ALMIRALL, S.A.

Inventor： Monica APARICI VIRGILI ,  Marta CALBET MURTRO ,  Montserrat MIRALPEIX GUELL ,  Amadeu GAVALDA MONEDERO ,  Carlos PUIG DURAN

IPC: A61K31/4709 ,  A61K45/06 ,  A61K31/56 ,  A61K31/58

CPC classification number: A61K31/4709 ,  A61K9/0075 ,  A61K9/008 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  C07D409/14 ,  A61K2300/00

Abstract: A combination which comprises (a) corticosteroid and (b) a dual muscarinic antagonist-β2 adrenergic agonist compound, or any pharmaceutically acceptable salt or solvate thereof.

公开(公告)号：US20150329535A1

公开(公告)日：2015-11-19

申请号：US14653048

申请日：2013-12-17

Applicant: ALMIRALL, S.A.

Inventor： Laia SOLE FEU ,  Ines CARRANCO MORUNO ,  Jose AIGUADE BOSCH ,  Carlos PUIG DURAN ,  Silvia FONQUERNA POU

IPC: C07D453/04 ,  C07D401/12 ,  A61K45/06 ,  C07D215/26 ,  A61K31/4704 ,  C07D413/12 ,  A61K31/4709 ,  A61K31/475

CPC classification number: C07D453/04 ,  A61K31/13 ,  A61K31/4184 ,  A61K31/439 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/475 ,  A61K45/06 ,  A61K47/55 ,  C07C271/38 ,  C07C2601/14 ,  C07D213/75 ,  C07D215/26 ,  C07D249/18 ,  C07D401/12 ,  C07D413/12 ,  C07D453/02

Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。

公开(公告)号：US20150328194A1

公开(公告)日：2015-11-19

申请号：US14652817

申请日：2013-12-13

Applicant: ALMIRALL, S.A.

Inventor： Diana JARRETA FERNANDEZ ,  Maria Esther GARCIA GIL

IPC: A61K31/439 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/439 ,  A61K9/0075 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides aclidinium or any of its steroisomers or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for improving the physical activity in respiratory patients.

Abstract translation: 本发明提供了吖啶鎓或其任何立体异构体或其立体异构体或其药学上可接受的盐或溶剂合物的混合物，用于改善呼吸患者的身体活动。