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公开(公告)号：US20180244626A1
公开(公告)日：2018-08-30
申请号：US15559120
申请日：2016-03-22
Applicant: ALMIRALL, S.A.
Inventor： Laia SOLE FEU , Silvia FONQUERNA POU
IPC: C07D231/56 , A61K31/416 , A61K45/06 , C07D401/04 , A61K31/454 , A61K31/4545 , A61K31/4439 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/4985 , A61K31/5377 , C07D405/10
CPC classification number: C07D231/56 , A61K31/416 , A61K31/4162 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D405/10 , C07D471/04 , C07D487/04
Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav 1.7, to compositions containing said derivatives and processes for their preparation,
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2.发明申请NEW CYCLOHEXYL AND QUINUCLIDINYL CARBAMATE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITY 有权具有BETA2 ADRENERGIC AGONIST和M3 MUSCARINIC ANTAGONIST活性的新CYCLOHEXYL和喹啉喹啉衍生物公开(公告)号：US20150329535A1
公开(公告)日：2015-11-19
申请号：US14653048
申请日：2013-12-17
Applicant: ALMIRALL, S.A.
Inventor： Laia SOLE FEU , Ines CARRANCO MORUNO , Jose AIGUADE BOSCH , Carlos PUIG DURAN , Silvia FONQUERNA POU
IPC: C07D453/04 , C07D401/12 , A61K45/06 , C07D215/26 , A61K31/4704 , C07D413/12 , A61K31/4709 , A61K31/475
CPC classification number: C07D453/04 , A61K31/13 , A61K31/4184 , A61K31/439 , A61K31/4704 , A61K31/4709 , A61K31/475 , A61K45/06 , A61K47/55 , C07C271/38 , C07C2601/14 , C07D213/75 , C07D215/26 , C07D249/18 , C07D401/12 , C07D413/12 , C07D453/02
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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公开(公告)号：US20180105509A1
公开(公告)日：2018-04-19
申请号：US15567668
申请日：2016-04-20
Applicant: ALMIRALL, S.A.
Inventor： James DUFFY , Mark Stuart CHAMBERS , Alastair RAE , James OSBORNE , Isabelle Anne LEMASSON , Michael Daniel GOLDSMITH , Andrew SHARPE , Silvia FONQUERNA POU
IPC: C07D401/12 , C07D231/38 , C07D249/06 , C07D401/14 , C07D403/10 , C07D403/12 , A61P25/02
CPC classification number: C07D401/12 , A61P25/02 , C07D231/38 , C07D249/06 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14
Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.
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4.发明申请NEW CYCLOHEXYLAMINE DERIVATIVES HAVING ß2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES 有权具有β2ADRENERGIC AGONIST和M3 MUSCARINIC ANTAGONIST活动的新CYCLOHEXYLAMINE衍生物公开(公告)号：US20160264557A1
公开(公告)日：2016-09-15
申请号：US15068926
申请日：2016-03-14
Applicant: Almirall, S.A.
Inventor： Maria PRAT QUINONES , Silvia FONQUERNA POU , Carlos PUIG DURAN , Wenceslao LUMERAS AMADOR , Jose AIGUADE BOSCH , Juan Francisco CATURLA JAVALOYES
IPC: C07D409/14 , C07D409/12 , C07D215/26 , C07D413/14 , C07D405/12
CPC classification number: C07D409/14 , A61K31/4709 , C07D215/26 , C07D405/12 , C07D409/12 , C07D413/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β2肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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