-
公开(公告)号：US07915273B2
公开(公告)日：2011-03-29
申请号：US12711534
申请日：2010-02-24
申请人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
发明人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
-
公开(公告)号：US07906644B2
公开(公告)日：2011-03-15
申请号：US11539013
申请日：2006-10-05
申请人： Rajinder Singh , Ankush Argade , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： C07D237/00
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括 在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。
-
公开(公告)号：US07858633B2
公开(公告)日：2010-12-28
申请号：US11567276
申请日：2006-12-06
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
-
公开(公告)号：US07820819B2
公开(公告)日：2010-10-26
申请号：US11539049
申请日：2006-10-05
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
IPC分类号： C07D239/02
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
-
公开(公告)号：US20100197918A1
公开(公告)日：2010-08-05
申请号：US12762178
申请日：2010-04-16
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
IPC分类号： C07D239/48
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括 在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。
-
公开(公告)号：US07642351B2
公开(公告)日：2010-01-05
申请号：US11539029
申请日：2006-10-05
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
IPC分类号： C07D239/02
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括 在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。
-
公开(公告)号：US20090171086A1
公开(公告)日：2009-07-02
申请号：US12363537
申请日：2009-01-30
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha J. Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B. Rossi
IPC分类号： C07D401/12 , C07D405/12 , C07D413/12 , C07D411/12
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括 在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。
-
48.发明授权公开(公告)号：US07517886B2
公开(公告)日：2009-04-14
申请号：US10631029
申请日：2003-07-29
申请人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： A61K31/4965
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
-
公开(公告)号：US20080009494A1
公开(公告)日：2008-01-10
申请号：US11567276
申请日：2006-12-06
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： A61K31/535 , A61K31/506 , A61P35/00 , C07D413/02
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
-
公开(公告)号：US20070299060A1
公开(公告)日：2007-12-27
申请号：US11567506
申请日：2006-12-06
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： A61K31/497 , A61K31/505 , A61K31/535 , A61K31/54 , A61P43/00 , C07D239/02 , C07D403/00 , C07D413/00 , C07D417/00 , C12N5/06
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
-
-
-
-
-
-
-
-
-
搜索结果
146 条记录 (耗时 0.109 秒)
