公开(公告)号：US06821991B2

公开(公告)日：2004-11-23

申请号：US10440788

申请日：2003-05-19

Applicant: Baihua Hu

Inventor： Baihua Hu

IPC: A61K31445

CPC classification number: C07D417/14 ,  A61K31/4412 ,  A61K31/4709 ,  A61K31/5377 ,  C07D277/54 ,  C07D417/10 ,  C07D417/12

Abstract: This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

Abstract translation: 本发明提供具有结构的式I化合物，其中A，X，Y，Z，R 1，R 2，R 3，R 4，R 5和R 6如上所定义，或其药学上可接受的盐，其可用于治疗或抑制代谢 与胰岛素抵抗或高血糖相关的疾病（通常与肥胖或葡萄糖不耐受相关），动脉粥样硬化，胃肠道疾病，神经源性炎症和尿频; 并且特别可用于治疗或抑制II型糖尿病。

公开(公告)号：US06797708B2

公开(公告)日：2004-09-28

申请号：US10302636

申请日：2002-11-22

Applicant: John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

Inventor： John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

IPC: C07D40106

CPC classification number: C07D209/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10

Abstract: This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Abstract translation: 本发明提供以下通式的取代的吲哚化合物及其药学上可接受的盐形式，以及使用该化合物作为各种磷脂酶，特别是磷脂酶A2酶的活性抑制剂以及用于治疗，预防和抑制疼痛的方法 和炎症。