公开(公告)号：US20100035957A1

公开(公告)日：2010-02-11

申请号：US12539074

申请日：2009-08-11

Applicant: John C. McKew ,  Steve Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark L. Behnke ,  Baihua Hu ,  James D. Clark ,  Wei Li ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

Inventor： John C. McKew ,  Steve Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark L. Behnke ,  Baihua Hu ,  James D. Clark ,  Wei Li ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

IPC: A61K31/405 ,  A61P9/10 ,  A61P25/28

CPC classification number: A61K31/505 ,  C07D209/14 ,  C07D209/16 ,  C07D209/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10

Abstract: This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.

Abstract translation: 本发明提供了使用通式的取代的吲哚化合物及其药学上可接受的盐形式的方法。 本发明提供了使用化合物作为各种磷脂酶，特别是磷脂酶A2酶的活性的抑制剂的方法，以及用于医学治疗，预防和抑制疾病和病症，包括哮喘，中风，动脉粥样硬化，多发性硬化，帕金森病， 关节炎疾病，风湿病，中风引起的中枢神经系统损伤，由缺血引起的中枢神经系统损伤，由创伤引起的中枢神经系统损伤，由前列腺素引起或增强的炎症，由白细胞三烯引起或增强的炎症，血小板引起或增强的炎症 活化因子，由前列腺素引起或增强的疼痛，由白三烯引起或加剧的疼痛，以及血小板激活因子引起或增强的疼痛。

公开(公告)号：US07433838B2

公开(公告)日：2008-10-07

申请号：US11153652

申请日：2005-06-15

Applicant: David Welsh ,  Frederick C. Chong ,  James D. Clark ,  Max G. Morris

Inventor： David Welsh ,  Frederick C. Chong ,  James D. Clark ,  Max G. Morris

IPC: G06Q40/00

CPC classification number: G06Q10/06 ,  G06Q30/00 ,  G06Q40/00

Abstract: Methods and apparatus for managing business interactions between opposing parties. Business interactions are mapped to service contracts. The service contracts are mapped to machine readable code. The machine readable code is defined by business transaction patterns and service interaction patterns. The machine readable code is consumed by an IT system. Management tasks associated with fulfilling obligations required by the business interactions are generated.

Abstract translation: 管理对方之间的业务互动的方法和设备。 业务互动映射到服务合同。 服务合同映射到机器可读代码。 机器可读代码由业务交易模式和服务交互模式定义。 机器可读代码由IT系统使用。 生成与履行业务交互所要求的义务相关联的管理任务。

公开(公告)号：US07101875B2

公开(公告)日：2006-09-05

申请号：US10302087

申请日：2002-11-22

Applicant: John C. McKew ,  Steve Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

Inventor： John C. McKew ,  Steve Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

IPC: A61K31/404 ,  A61K31/54 ,  A61K31/42 ,  A61K31/41 ,  A61K31/40

CPC classification number: C07D401/12 ,  C07D209/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10

Abstract: This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Abstract translation: 本发明提供使用以下通式的取代的吲哚化合物及其药学上可接受的盐形式来治疗哺乳动物关节炎或风湿病的方法，以及使用这些化合物作为各种磷脂酶的活性抑制剂的方法，特别是磷脂酶A 2酶，并用于治疗，预防和抑制疼痛和炎症。

公开(公告)号：US06984735B2

公开(公告)日：2006-01-10

申请号：US10722782

申请日：2003-11-26

Applicant: John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark ,  Wei Li

Inventor： John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark ,  Wei Li

IPC: C07D215/38 ,  C07D217/12

CPC classification number: C07D401/12 ,  C07D209/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10

Abstract: A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.

Abstract translation: 在没有有效量的活化剂的情况下，使亚砜与二卤代芳香族化合物反应的芳香醛的制造方法。 然后可以使用醛来制备其它化合物，例如充当cPLA抑制剂的化合物。

公开(公告)号：US5389020A

公开(公告)日：1995-02-14

申请号：US12420

申请日：1993-02-02

Applicant: James D. Clark

Inventor： James D. Clark

IPC: B63H5/14 ,  F02B3/06 ,  F02B61/04 ,  B63H1/16

CPC classification number: B63H5/14 ,  F02B3/06 ,  F02B61/045

Abstract: A housing for the prop of a conventional gasoline or diesel powered marine engine is provided attachable to a bracket mount on the engine. The housing completely encloses the engine's prop and drive shaft and defines a tubular flow path for the water engaged by the prop with the flow path being generally coaxial with respect to the prop's rotation axis. The housing has an anterior inlet port of cross-sectional area A1 and a posterior outlet port of cross-sectional area A2 wherein A1>A2. A smooth transition of the different cross-sectional areas of the tubular housing is effected by an intermediate tapered section. Drive shaft extension means are provided so that the prop rotates in the region of the housing's least cross-sectional area.

Abstract translation: 用于支撑常规汽油或柴油动力船用发动机的壳体被设置成可附接到发动机上的支架安装件。 壳体完全包围发动机的支柱和驱动轴并且限定用于由道路接合的水的管状流动路径，其中流动路径相对于支柱的旋转轴线大致同轴。 壳体具有横截面积A1的前入口和横截面积A2的后出口，其中A1> A2。 管状壳体的不同横截面积的平滑过渡由中间锥形部分实现。 驱动轴延伸装置设置成使得支架在壳体的最小横截面积的区域内旋转。

公开(公告)号：US2350711A

公开(公告)日：1944-06-06

申请号：US42273641

申请日：1941-12-12

Applicant: TIMOTHY B MCCARTHY ,  JAMES D CLARK

Inventor： AMOS HOWARD W

IPC: A47C23/047

CPC classification number: A47C23/047 ,  Y10S297/03 ,  Y10S297/08

公开(公告)号：US07906548B2

公开(公告)日：2011-03-15

申请号：US12539074

申请日：2009-08-11

Applicant: John C. McKew ,  Steve Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark L. Behnke ,  Baihua Hu ,  James D. Clark ,  Wei Li ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

Inventor： John C. McKew ,  Steve Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark L. Behnke ,  Baihua Hu ,  James D. Clark ,  Wei Li ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

IPC: A01N43/38

CPC classification number: A61K31/505 ,  C07D209/14 ,  C07D209/16 ,  C07D209/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10

Abstract: This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.

Abstract translation: 本发明提供了使用通式的取代的吲哚化合物及其药学上可接受的盐形式的方法。 本发明提供了使用化合物作为各种磷脂酶，特别是磷脂酶A2酶的活性的抑制剂的方法，以及用于医学治疗，预防和抑制疾病和病症，包括哮喘，中风，动脉粥样硬化，多发性硬化，帕金森病， 关节炎疾病，风湿病，中风引起的中枢神经系统损伤，由缺血引起的中枢神经系统损伤，由创伤引起的中枢神经系统损伤，由前列腺素引起或增强的炎症，由白细胞三烯引起或增强的炎症，血小板引起或增强的炎症 活化因子，由前列腺素引起或增强的疼痛，由白三烯引起或加剧的疼痛，以及血小板激活因子引起或增强的疼痛。

公开(公告)号：US06797708B2

公开(公告)日：2004-09-28

申请号：US10302636

申请日：2002-11-22

Applicant: John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

Inventor： John C. McKew ,  Steven Y. Tam ,  Katherine L. Lee ,  Lihren Chen ,  Paresh Thakker ,  Fuk-Wah Sum ,  Mark Behnke ,  Baihua Hu ,  James D. Clark

IPC: C07D40106

CPC classification number: C07D209/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/10

Abstract: This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Abstract translation: 本发明提供以下通式的取代的吲哚化合物及其药学上可接受的盐形式，以及使用该化合物作为各种磷脂酶，特别是磷脂酶A2酶的活性抑制剂以及用于治疗，预防和抑制疼痛的方法 和炎症。

公开(公告)号：US20100022536A1

公开(公告)日：2010-01-28

申请号：US12488182

申请日：2009-06-19

Applicant: John C. McKew ,  Katherine L. Lee ,  Lihren Chen ,  Richard Vargas ,  James D. Clark ,  Cara Williams ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

Inventor： John C. McKew ,  Katherine L. Lee ,  Lihren Chen ,  Richard Vargas ,  James D. Clark ,  Cara Williams ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

IPC: A61K31/5377 ,  A61K31/405 ,  A61K31/497 ,  A61P29/00 ,  A61P11/06 ,  A61P19/02 ,  A61P25/16 ,  A61P25/00 ,  A61P7/02

CPC classification number: C07D209/14 ,  C07D209/18

Abstract: This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2α). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

公开(公告)号：US07557135B2

公开(公告)日：2009-07-07

申请号：US11442199

申请日：2006-05-26

Applicant: John C. McKew ,  Katherine L. Lee ,  Lihren Chen ,  Richard Vargas ,  James D. Clark ,  Cara Williams ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

Inventor： John C. McKew ,  Katherine L. Lee ,  Lihren Chen ,  Richard Vargas ,  James D. Clark ,  Cara Williams ,  Valerie Clerin ,  Suzana Marusic ,  Kevin Pong

IPC: A61K31/404 ,  C07D209/14

CPC classification number: C07D209/14 ,  C07D209/18

Abstract: This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2α). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

Abstract translation: 本发明提供了各种磷脂酶，特别是细胞溶质磷脂酶A2酶（cPLA2）的活性的化学抑制剂，更具体地包括胞浆磷脂酶A2α酶（cPLA2α）的抑制剂。 在一些实施方案中，抑制剂具有式I：其中组成变量如本文所定义。