公开(公告)号：US20170191060A1

公开(公告)日：2017-07-06

申请号：US15400912

申请日：2017-01-06

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12N15/10

CPC classification number: C12N15/115 ,  C12N2310/16

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules such as ricin, particularly to ricin B chain.

公开(公告)号：US20150353932A1

公开(公告)日：2015-12-10

申请号：US14297484

申请日：2014-06-05

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12N15/117

CPC classification number: C12N15/115 ,  C12N15/117 ,  C12N2310/16 ,  C12N2310/17 ,  C12N2320/13

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

Abstract translation: 本发明涉及功能性配体与靶分子，特别是功能性核酸及其修饰，以及用于同时产生例如多种不同功能生物分子的方法，特别涉及同时产生多种不同功能性核酸的方法。 本发明还涉及与靶分子具有亲和力结合的功能性配体。

公开(公告)号：US20130157871A1

公开(公告)日：2013-06-20

申请号：US13652361

申请日：2012-10-15

Applicant: BASE PAIR BIOTECHNOLOGIES, INC.

Inventor： George Jackson

IPC: C12Q1/68

CPC classification number: C12Q1/6837 ,  C07K1/22

Abstract: The present invention relates to methods for generating functional biomolecules. In one exemplary aspect of the invention, generation of functional biomolecules may be performed against multiple targets simultaneously within a single system. In general, a plurality of targets may be disposed within in a single reaction volume and a library of biomolecules, such as a nucleic acid library, may be applied to the reaction volume. The members of the library that do not bind to any of the plurality of targets under given conditions may then be partitioned. The remaining members of the library may then be marked and/or tagged, such as to identify the particular target or targets to which the member of the library binds. The binding members of the library may then be isolated and, by virtue of the marking or tagging, be matched to a particular target or targets.

Abstract translation: 本发明涉及产生功能性生物分子的方法。 在本发明的一个示例性方面，功能性生物分子的产生可以在单个系统内同时针对多个靶标进行。 通常，多个靶可以设置在单个反应体积内，并且生物分子文库（例如核酸文库）可以应用于反应体积。 在给定条件下不绑定到任何多个目标的库的成员可以被划分。 然后可以标记和/或标记图书馆的剩余成员，例如识别图书馆成员所绑定的特定目标或目标。 然后可以分离图书馆的约束成员，并且通过标记或标记来匹配特定的目标或目标。