公开(公告)号：US20210123056A1

公开(公告)日：2021-04-29

申请号：US17052610

申请日：2019-05-03

Applicant: BASE PAIR BIOTECHNOLOGIES, INC.

Inventor： George W. Jackson ,  Robert Batchelor ,  Truong Nguyen ,  Anna Hickey ,  Caitlin Huddleston ,  Vinoth Sankarapani

IPC: C12N15/115

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as herbicides, such as dicamba.

公开(公告)号：US10920228B2

公开(公告)日：2021-02-16

申请号：US16262769

申请日：2019-01-30

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Robert Batchelor ,  Alexander S. Chiu ,  Rafal Drabek ,  Deepak Thirunavukarasu

IPC: C12N15/11 ,  C12N15/115 ,  C12N15/10

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as biocide molecules.

公开(公告)号：US10415041B2

公开(公告)日：2019-09-17

申请号：US15893532

申请日：2018-02-09

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/11 ,  C12N15/115 ,  C12N15/10

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as amino acids, such as citrulline, and to target molecules such as crystallin or its subunits, such as alpha crystallin B-chain (CRYAB).

公开(公告)号：US20190249245A1

公开(公告)日：2019-08-15

申请号：US16262777

申请日：2019-01-30

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Robert Batchelor ,  Rafal Drabek ,  Caitlin Bruns

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q1/6848 ,  C40B30/04

CPC classification number: C12Q1/6874 ,  C12N15/1048 ,  C12N15/115 ,  C12N2310/16 ,  C12N2330/31 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6848 ,  C12Q1/6876 ,  C40B30/04

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as lipoarabinomannan (LAM).

公开(公告)号：US20190112605A1

公开(公告)日：2019-04-18

申请号：US16075663

申请日：2017-02-06

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules such as immunoglobulins, such as IgG.

公开(公告)号：US20170009236A9

公开(公告)日：2017-01-12

申请号：US14297484

申请日：2014-06-05

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12N15/115 ,  C12N15/117

CPC classification number: C12N15/115 ,  C12N15/117 ,  C12N2310/16 ,  C12N2310/17 ,  C12N2320/13

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

Abstract translation: 本发明涉及功能性配体与靶分子，特别是功能性核酸及其修饰，以及用于同时产生例如多种不同功能生物分子的方法，特别涉及同时产生多种不同功能性核酸的方法。 本发明还涉及与靶分子具有亲和力结合的功能性配体。

公开(公告)号：US11608356B1

公开(公告)日：2023-03-21

申请号：US16798314

申请日：2020-02-22

Applicant: Base Pair Biotechnologies, Inc.

Inventor： Robert Batchelor ,  George W. Jackson ,  Truong Nguyen ,  Vinoth Sankarapani

IPC: C12N15/115 ,  C07H21/04 ,  C07H21/02

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as antibiotics, such as colistin.

公开(公告)号：US20210395920A1

公开(公告)日：2021-12-23

申请号：US17460513

申请日：2021-08-30

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Robert Batchelor ,  Alexander S. Chiu ,  Rafal Drabek ,  Deepak Thirunavukarasu ,  Caitlin Bruns

IPC: C40B40/06 ,  C12Q1/6811 ,  C12Q1/6837

Abstract: This invention relates to methods and materials for multiplexed utilization of collections of functional ligands, particularly to methods and materials for selecting for and/or utilizing particular desirable traits of functional ligands in a multiplexed manner, and more particularly to methods and materials for selecting for and/or utilizing particular structural changes of functional ligands in a multiplexed manner.

公开(公告)号：US10538770B2

公开(公告)日：2020-01-21

申请号：US15712042

申请日：2017-09-21

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson

IPC: C12Q1/68 ,  C12N15/115 ,  C12Q1/6811 ,  C12Q1/70

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules such as chikungunya viral proteins, such as chikungunya envelope protein E1.

公开(公告)号：US20190119681A1

公开(公告)日：2019-04-25

申请号：US15959389

申请日：2018-04-23

Applicant: Base Pair Biotechnologies, Inc.

Inventor： George W. Jackson ,  Darryl Bornhop

IPC: C12N15/115 ,  G01N21/47 ,  G01N33/542 ,  G01N33/53

Abstract: The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.