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公开(公告)号：US20230136293A1
公开(公告)日：2023-05-04
申请号：US17514245
申请日：2021-10-29
Applicant: Trustees of Dartmouth College
Inventor： Timothy J. Pierson , Jonathan F. Alter
IPC: H04W12/50 , H04W76/10 , H04B17/318 , H04L12/26 , G16Y30/10 , H04W12/06 , H04L9/32 , H04W12/041
Abstract: Methods of pairing devices wirelessly that include matching received-signal-strength information regarding signal-strength patterns received by differing devices desired to be paired. In some embodiments, signal-strength patterns are based on a user moving an object so as to intentionally create multipath Fresnel-zone propagation disturbances. During pairing, the devices exchange their received-signal-strength information with one another and compare the received-signal-strength information that they receive from another device to the received-signal-strength information that they generated themselves based on the multipath Fresnel-zone propagation disturbances. When the two sets of receive-signal-strength information substantially match one another, the devices determine the presence of a trusted relationship. Methods for assisting with the wireless pairing are also disclosed. Disclosed methods can be encoded in software/firmware, and such software/firmware can be stored in devices desired to include disclosed wireless pairing functionality.
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公开(公告)号：US20230047584A1
公开(公告)日：2023-02-16
申请号：US17794297
申请日：2021-11-15
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr BRUZA , Brian POGUE
Abstract: A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter-changer or tunable filter is between the tissue and the electronic camera with fluorescent imaging settings and a stimulus wavelength setting, and an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue.
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43.发明申请公开(公告)号：US20230020195A1
公开(公告)日：2023-01-19
申请号：US17948434
申请日：2022-09-20
Applicant: The Trustees of Dartmouth College
Inventor： Stephen Chad Kanick , Brian William Pogue , Keith D. Paulsen , Jonathan T. Elliott , David M. McClatchy, III , Venkataramanan Krishnaswamy
IPC: A61B5/00
Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.
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公开(公告)号：US20230018163A1
公开(公告)日：2023-01-19
申请号：US17782952
申请日：2020-12-09
Applicant: Trustees of Dartmouth College
Inventor： Edward Matios , Huan Wang , Weiyang Li
IPC: H01M10/056 , H01M10/054
Abstract: In an embodiment, the present disclosure pertains to a non-aqueous electrolyte. In some embodiments, the non-aqueous electrolyte includes a polymeric component and a ceramic component. The polymeric component includes a polyester-based polymer and a polyether-based polymer. The ceramic component includes inorganic materials. In an additional embodiment, the present disclosure pertains to an energy storage device including an anode, a cathode, and a non-aqueous electrolyte of the present disclosure. In a further embodiment, the present disclosure pertains to a method of making a non-aqueous electrolyte by mixing a polymeric component and a ceramic component of the present disclosure.
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公开(公告)号：US11553842B2
公开(公告)日：2023-01-17
申请号：US16799721
申请日：2020-02-24
Applicant: The Trustees of Dartmouth College
Inventor： Shadab Khan , Ryan Halter
Abstract: A surgical vision system for imaging heat capacity and cooling rate of tissue has an infrared source configured to provide infrared light to tissue, the infrared light sufficient to heat tissue, and an infrared camera configured to provide images of tissue at infrared wavelengths. The system also has an image processing system configured to determine, from the infrared images of tissue, a cooling or heating rate at pixels of the images of tissue at infrared wavelengths and to display images derived from the cooling rate at the pixels.
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Patent Agency Ranking
公开(公告)号：US11534558B2
公开(公告)日：2022-12-27
申请号：US17628543
申请日：2020-07-17
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Douglas W. Van Citters , Alexander H. Slocum, Jr. , Steven D. Reinitz
Abstract: A bilateral humeral guide for intraosseous infusion includes a three-dimensional mirror symmetric shell configured to fit on either shoulder of a patient, the shell being symmetric about a plane bisecting an alignment hole configured to aid positioning of the shell on the shoulder by aligning the alignment hole on acromion of the shoulder, and two insertion-site indication holes symmetrically positioned on two opposite sides of the plane, the insertion-site indication holes including a left and a right hole each configured to indicate insertion sites for intraosseous infusion through the shell to a target region of a left or right humerus of the patient when the shell is positioned on the shoulder corresponding to the respective humerus.
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公开(公告)号：US11519753B2
公开(公告)日：2022-12-06
申请号：US16596346
申请日：2019-10-08
Applicant: Trustees of Dartmouth College
Inventor： Jun Gong , Xing-Dong Yang
Abstract: Aspects of the disclosure provide a sensing apparatus including a sensing device, a memory, and processing circuitry. The sensing device includes resonators having respective resonant frequencies. The resonators include an array of inductive coils positioned on a surface of the apparatus. The sensing device can output a signal indicating changes of the resonant frequencies caused by presence of an object proximate to the surface. The memory stores reference signals corresponding to reference objects. Each reference signal indicates changes of the resonant frequencies caused by the respective reference object proximate to the surface. The processing circuitry can receive, from the sensing device, a particular signal indicating changes of the resonant frequencies caused by presence of a particular object proximate to the surface. The processing circuitry compares the particular signal with the stored reference signals of the reference objects to determine an identity of the particular object.
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公开(公告)号：US20220348872A1
公开(公告)日：2022-11-03
申请号：US17746362
申请日：2022-05-17
Applicant: TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Charles L. Sentman , Benjamine H. Arellano
IPC: C12N5/0783 , A61K35/17 , A61K38/17 , C07K14/705 , C07K14/47 , C07K14/54 , C07K16/18
Abstract: A nucleic acid construct and an immune cell, which harbor nucleic acids encoding a CAR and nucleic acids encoding at least one anti-inflammatory or immunosuppressant protein and methods of using the same in treatment or amelioration of inflammation or immune-mediated autoimmunity are described.
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公开(公告)号：US11459353B2
公开(公告)日：2022-10-04
申请号：US16637675
申请日：2018-08-16
Applicant: Trustees of Dartmouth College
Inventor： Glenn C. Micalizio
Abstract: Methods for producing enantiodefined polycyclic compounds, particularly tetracyclic compounds, are provided. More particularly, synthetic methods for producing biologically active enantiodefined steroidal compositions of both natural (“nat-”) and unnatural (“ent-”) absolute stereochemistry are provided. An exemplary method for manufacturing a tetracyclic compound comprises a step of forming a hydrindane intermediate through coupling of a suitably functionalized enyne with a suitably functionalized alkyne and subsequently performing an intramolecular ring-closing reaction to form the tetracyclic compound. Steroidal compounds obtained by this method and methods of using such steroidal compounds in human and/or animal therapeutics and medicines are also provided.
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公开(公告)号：US20220203438A1
公开(公告)日：2022-06-30
申请号：US17602409
申请日：2020-04-20
Applicant: Trustees of Dartmouth College
Inventor： John X.J. Zhang , Nanjing Hao , Yuan Nie
Abstract: In an embodiment, the present disclosure pertains to a method of making magnetic nanoparticles through the utilization of a microfluidic reactor. In some embodiments, the microfluidic reactor includes a first inlet, a second inlet, and an outlet. In some embodiments, the method includes applying a magnetic nanoparticle precursor solution into the first inlet of the microfluidic reactor through a first flow rate and applying a reducing agent into the second inlet of the microfluidic reactor through a second flow rate. In some embodiments, the magnetic nanoparticles are produced in the microfluidic reactor and collected from the outlet of the microfluidic reactor. In an additional embodiment, the present disclosure pertains to a composition including a plurality of magnetic nanoparticles. In a further embodiment, the present disclosure pertains to a microfluidic reactor.
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