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公开(公告)号：US20230350086A1
公开(公告)日：2023-11-02
申请号：US17796488
申请日：2021-01-29
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
Inventor： Petr BRUZA , Brian POGUE , Venkataramanan KRISHNASWAMY
Abstract: A Cherenkov imaging system includes a high-speed radiation detector configured to provide a first timing signal synchronized with pulses of radiation to control operation of at least one pulse-gated, multiple-pulse-integrating, (PG-MPI) CMOS camera synchronized through the digital time signal to pulses of the radiation beam source, to image Cherenkov radiation; and a digital image-processing system. The high-speed radiation detector is either a solid-state radiation detector or a scintillator with a photodetector. The system images Cherenkov light emitted by tissue by using a timing signal synchronized to pulses of a pulsed radiation beam to control the PG-MPI camera by integrating light received by the PG-MPI camera during multiple pulses of the radiation beam while excluding light received by the camera between pulses of the radiation beam.
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Patent Agency Ranking
2.发明公开公开(公告)号：US20240000316A1
公开(公告)日：2024-01-04
申请号：US18229086
申请日：2023-08-01
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr BRUZA , Brian POGUE
CPC classification number: A61B5/0071 , A61B5/7425 , G01N21/645 , A61B2560/0233 , A61B2576/00 , G01N2021/6471
Abstract: A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter device is between the tissue and the electronic camera with fluorescent imaging and stimulus wavelength settings. an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue. Then image processor derives a fluorescence lifetime signal from the received temporal fluorescence signals and derives from these fluorescence lifetime signals biochemical property images of the tissue.
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公开(公告)号：US20230047584A1
公开(公告)日：2023-02-16
申请号：US17794297
申请日：2021-11-15
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr BRUZA , Brian POGUE
Abstract: A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter-changer or tunable filter is between the tissue and the electronic camera with fluorescent imaging settings and a stimulus wavelength setting, and an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue.
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公开(公告)号：US20240248211A1
公开(公告)日：2024-07-25
申请号：US18289533
申请日：2022-05-04
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr BRUZA
CPC classification number: G01S17/89 , G01S17/18 , G02B26/0833 , H04N23/55
Abstract: A gated camera has an image-sensing device, a spatial-light modulator that directs part or all of an incident optical beam toward the image-sensing device or away from the image-sensing device under control of a controller; and a beam-directing element that directs the incident optical beam toward the spatial-light modulator. A gated image acquisition method includes controlling whether a temporal segment of an incident optical beam contributes to an image captured by an image sensor by directing the temporal segment either toward the image sensor or away from the image sensor. A method for spatially encoding a temporally-varying light signal comprising, for each of a plurality of temporal segments of the temporally-varying light signal selectively directing the temporal segment of the temporally-varying light signal to a respective region of an image sensor, or directing the temporal segment of the temporally-varying light signal away from the image sensor.
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公开(公告)号：US20220280815A1
公开(公告)日：2022-09-08
申请号：US17626488
申请日：2020-07-10
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
Inventor： Petr BRUZA , Brian POGUE , Michael JERMYN , Venkataramanan KRISHNASWAMY
Abstract: A system for performing radiation treatment of a patient with a proton beam from a particle accelerator uses a high-sensitivity camera to capture dose images of patient surface, a video processor that integrates the dose images, beam-on detection apparatus, and apparatus to eliminate interference of room lighting. In embodiments, the system registers dose images to a surface model of the patient derived from stereo image pairs captured by a stereo camera. In embodiments, the surface model is registered to three-dimensional images of the patient from MRI or CT, and an integrated three-dimensional energy deposition map of the patient is prepared.
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公开(公告)号：US20220257982A1
公开(公告)日：2022-08-18
申请号：US17627633
申请日：2020-07-15
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Rachael HACHADORIAN , Brian POGUE , Petr BRUZA , Lesley JARVIS
Abstract: A system for monitoring radiation treatment images Cherenkov emissions from tissue of a subject. A processor of the system determines densities of a surface layer of the subject from 3D images of the tissue to determine correction factors. The processor uses these factors to correct the Cherenkov images for attenuation of Cherenkov light by tissue, making them proportional to radiation dose. In embodiments, the system obtains reflectance images of the subject, determines second correction factors therefrom, and applies the second correction factors to the Cherenkov emissions images. In embodiments, the corrected images of Cherenkov emissions are compared to dose maps of a treatment plan. A method of correcting Cherenkov emissions images includes determining tissue characteristics from CT or MRI images in a surface volume where Cherenkov is expected, using; imaging Cherenkov emissions; and using the tissue characteristics to correct the images for variations in Cherenkov light propagation through the tissue.
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