公开(公告)号：US20100210617A1

公开(公告)日：2010-08-19

申请号：US11993835

申请日：2006-06-21

Applicant: Steven John Woodhead ,  Robert Downham ,  Christopher Hamlett ,  Steven Howard ,  Hannah Fiona Sore ,  Marinus Leendert Verdonk ,  David Winter Walker ,  Richard William Arthur Luke

Inventor： Steven John Woodhead ,  Robert Downham ,  Christopher Hamlett ,  Steven Howard ,  Hannah Fiona Sore ,  Marinus Leendert Verdonk ,  David Winter Walker ,  Richard William Arthur Luke

IPC: A61K31/4155 ,  C07D231/12 ,  C07D403/10 ,  C07D413/10 ,  C07D413/14 ,  C07D401/10 ,  A61K31/415 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/497 ,  A61K31/454 ,  A61P35/00

CPC classification number: C07D231/12

Abstract: The invention provides a compound of the formula (II): or a salt, solvate, tautomer or N-oxide thereof; wherein n is 0 or 1; one of Y1 and Y2 is CH and the other is selected from CH, CR8 and N; q is 0, 1 or 2 provided that q is 0 or 1 when Y1 or Y2 is CR8; R1 aryl or heteroaryl group of 5 to 10 ring members; R2a and R3a each are hydrogen, C1-4 hydrocarbyl or C1-4 acyl wherein the hydrocarbyl and acyl moieties are optionally substituted by fluorine, hydroxy, amino, methylamino, dimethylamino or methoxy; or NR2aR3a forms an imidazole group or a saturated monocyclic 4-7 membered heterocyclic group optionally containing a second heteroatom ring member selected from O and N; R18 is hydrogen or methyl; R19 is hydrogen or methyl; R24 is hydrogen or R24, R2a and the intervening nitrogen atom and carbon atoms together form an azetidine, pyrrolidine or piperidine ring; R25 is hydrogen or a C1-4 alkyl group wherein the C1-4 alkyl group is optionally substituted by hydroxy or amino provided that there are at least two carbon atoms between the hydroxy or amino group and the oxygen atom to which R25 is attached; and R4 and R5 each are hydrogen or a substituent as defined in the claims

Abstract translation: 本发明提供式（II）化合物或其盐，溶剂合物，互变异构体或N-氧化物; 其中n为0或1; Y1和Y2之一是CH，另一个选自CH，CR8和N; q为0,1或2，条件是当Y1或Y2为CR8时q为0或1; R 10芳环或5至10个环成员的杂芳基; R2a和R3a各自为氢，C1-4烃基或C1-4酰基，其中烃基和酰基部分任选被氟，羟基，氨基，甲基氨基，二甲基氨基或甲氧基取代; 或NR2aR3a形成任选含有选自O和N的第二杂原子环成员的咪唑基或饱和单环4-7元杂环基; R18是氢或甲基; R 19是氢或甲基; R 24是氢或R 24，R 2a，并且插入的氮原子和碳原子一起形成氮杂环丁烷，吡咯烷或哌啶环; R 25是氢或C 1-4烷基，其中C 1-4烷基任选被羟基或氨基取代，条件是羟基或氨基与R 25所连接的氧原子之间至少有两个碳原子; 且R 4和R 5各自为氢或如权利要求中所定义的取代基

公开(公告)号：US20100093748A1

公开(公告)日：2010-04-15

申请号：US12520303

申请日：2007-12-21

Applicant: Steven John Woodhead ,  Martyn Frederickson ,  Christopher Hamlett ,  Andrew James Woodhead ,  Marinus Leendert Verdonk ,  Hannah Fiona Sore ,  David Winter Walker ,  Peter Blurton ,  Ian Collins ,  Kwai Ming Cheung ,  John Caldwell ,  Tatiana Faria Da Fonseca McHardy ,  Richard William Arthur Luke ,  Zbigniew Stanley Matusiak ,  Andrew Leach ,  Jeffrey James Morris

Inventor： Steven John Woodhead ,  Martyn Frederickson ,  Christopher Hamlett ,  Andrew James Woodhead ,  Marinus Leendert Verdonk ,  Hannah Fiona Sore ,  David Winter Walker ,  Peter Blurton ,  Ian Collins ,  Kwai Ming Cheung ,  John Caldwell ,  Tatiana Faria Da Fonseca McHardy ,  Richard William Arthur Luke ,  Zbigniew Stanley Matusiak ,  Andrew Leach ,  Jeffrey James Morris

IPC: A61K31/497 ,  C07D487/04 ,  A61K31/519 ,  C07D471/04 ,  A61K31/437

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/34 ,  C07D519/00

Abstract: The invention provides PKA and PKB kinase-inhibiting compounds of the formula (I): or salts, solvates, tautomers or N-oxides thereof, wherein E is a five membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from O, N and S provided that no more than 1 heteroatom may be other than N; q and r are each is 0 or 1; provided that q+r is 1 or 2; T is N or a group CR5; J1-J2 is N═C(R6), (R7)C═N, (R8)N—C(O), (R8)2C—C(O), N═N or (R7)C═C(R6); Q3 is a bond or a saturated C1-3 hydrocarbon linker group optionally substituted by fluorine and hydroxy; G is NR2R3, CN or OH; m and n are each 0 or 1, provided that m+n is 1 or 2, and provided also that m or n are each 0 when the adjacent ring member of ring E is S or O; R1a and R1b are the same or different and each is hydrogen or a substituent R10; or R1a and R1b together with the carbon atoms or heteroatoms to which they are attached form a 5 or 6-membered aryl or heteroaryl ring, wherein the aryl or heteroaryl rings are optionally substituted by one or more substituents R10; and R2, R3, R4, R5, R7, R6, R8, and R10 are as defined in the claims.

Abstract translation: 本发明提供式（I）的PKA和PKB激酶抑制化合物：或其盐，溶剂合物，互变异构体或N-氧化物，其中E是含有1,2,3或4个选自O， N和S的条件是不超过1个杂原子可以不是N; q和r各自为0或1; q + r为1或2; T为N或CR5基团; J1-J2是N = C（R6），（R7）C = N，（R8）N-C（O），（R8）2C-C（O），N = N或（R7）C = C ）; Q3是任选被氟和羟基取代的键或饱和C 1-3烃连接基团; G为NR2R3，CN或OH; m和n各自为0或1，条件是m + n为1或2，并且当环E的相邻环构件为S或O时，m或n各自为0; R1a和R1b相同或不同，各自为氢或取代基R10; 或R 1a和R 1b与它们所连接的碳原子或杂原子一起形成5或6元芳基或杂芳基环，其中芳基或杂芳基环任选被一个或多个取代基R 10取代; 并且R 2，R 3，R 4，R 5，R 7，R 6，R 8和R 10如权利要求中所定义。

公开(公告)号：US20100069637A1

公开(公告)日：2010-03-18

申请号：US12511503

申请日：2009-07-29

Applicant: Stephen Benedict David WINTER ,  Monica BENITO VELEZ ,  Ernesto DURAN LOPEZ

Inventor： Stephen Benedict David WINTER ,  Monica BENITO VELEZ ,  Ernesto DURAN LOPEZ

IPC: C07D471/04

CPC classification number: C07D487/04

Abstract: This invention provides novel crystalline acid salt forms of 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine, i.e. sitagliptin, to processes for their preparation and isolation, and to pharmaceutical compositions comprising the same.

Abstract translation: 本发明提供了新的7 - [（3R）-3-氨基-1-氧代-4-（2,4,5-三氟苯基）丁基] -5,6,7,8-四氢-3- （三氟甲基）-1,2,4-三唑并[4,3-a]吡嗪，即西他列汀，其制备和分离方法，以及包含其的药物组合物。

公开(公告)号：US20090093645A1

公开(公告)日：2009-04-09

申请号：US12097251

申请日：2006-12-12

Applicant: Stephen Benedict David Winter

Inventor： Stephen Benedict David Winter

IPC: C07D333/20

CPC classification number: C07D333/20

Abstract: The invention relates to an improved process for the preparation of duloxetine hydrochloride.

Abstract translation: 本发明涉及一种制备度洛西汀盐酸盐的改进方法。

公开(公告)号：US20090018346A1

公开(公告)日：2009-01-15

申请号：US12171366

申请日：2008-07-11

Applicant: Monica Benito Velez ,  Stephen Benedict David Winter ,  Nuria Soldevilla Madrid

Inventor： Monica Benito Velez ,  Stephen Benedict David Winter ,  Nuria Soldevilla Madrid

IPC: C07D405/10

CPC classification number: C07D405/06

Abstract: The present invention relates to amorphous form darifenacin hydrobromide and processes therefor. In addition, the present invention relates to compositions comprising amorphous form darifenacin hydrobromide.

Abstract translation: 本发明涉及无定形形式的达瑞芬酸氢溴酸盐及其制备方法。 此外，本发明涉及包含无定形形式的达立芬那酸氢溴酸盐的组合物。

公开(公告)号：US20070145717A1

公开(公告)日：2007-06-28

申请号：US11609319

申请日：2006-12-11

Applicant: DAVID WINTER ,  Brandon Smith ,  S. Nye ,  Mitch Johnson ,  Jered Larsen ,  Doug Fuller

Inventor： DAVID WINTER ,  Brandon Smith ,  S. Nye ,  Mitch Johnson ,  Jered Larsen ,  Doug Fuller

IPC: B60D1/54

CPC classification number: B60D1/54 ,  B60D1/143 ,  B62D63/061

Abstract: A folding trailer may be capable of moving between a use position and a storage position. The folding trailer may include an axle that is capable of moving between a first position in which the axle is generally aligned along an axis and a second position in which the axle is disposed in a folded configuration. The folding trailer may also include a towing arm that is movable between an extended position in which a portion of the towing arm extends beyond the front portion of the frame to facilitate attached to a towing vehicle and a collapsed position in which the towing arm is at least substantially disposed underneath the frame. In addition, the trailer may include an adjustment assembly that is sized and configured to adjust the position of the axle between the first and second positions, and adjust the position of the towing arm between the extended and collapsed positions. Advantageously, the adjustment assembly may have different configurations and arrangements. In addition, the adjustment assembly may be used to secure the trailer in the use or storage positions.

Abstract translation: 折叠式拖车可能能够在使用位置和存放位置之间移动。 折叠式拖车可以包括能够在第一位置和第二位置之间移动的车轴，其中车轴沿着轴线大致对准，在第二位置，轴以折叠的形式设置。 折叠拖车还可以包括牵引臂，牵引臂可在延伸位置之间移动，在该延伸位置中，牵引臂的一部分延伸超过框架的前部，以便于连接到牵引车辆和牵引臂处于其中的折叠位置 最少基本上设置在框架下方。 此外，拖车可以包括调节组件，其尺寸和构造用于调整在第一和第二位置之间的轴的位置，并且调节牵引臂在伸展位置和折叠位置之间的位置。 有利地，调节组件可以具有不同的构造和布置。 此外，调节组件可用于将拖车固定在使用或存放位置。

公开(公告)号：US20070132205A1

公开(公告)日：2007-06-14

申请号：US11609323

申请日：2006-12-11

Applicant: David Winter ,  BRANDON SMITH ,  Mitch Johnson ,  Jered Larsen ,  Robert Astle

Inventor： David Winter ,  BRANDON SMITH ,  Mitch Johnson ,  Jered Larsen ,  Robert Astle

IPC: B62D53/06

CPC classification number: B62D63/062 ,  B60D1/143 ,  B60D1/54

Abstract: A trailer may be purchased by a consumer from a store and the trailer may be quickly, easily and readily towed away from the store. In particular, the trailer may be essentially or completely ready to be towed away from the store and the trailer may require no or virtually no assembly. For example, a towing arm may be quickly and easily moved from the storage position to the use position. Advantageously, because the towing arm may be connected by pins to the trailer, no tools may be required to position the arm in the use position. In addition, because electrical wiring may be disposed within the arm and the arm may be simply moved forwardly when the trailer is ready to be towed, the lights for the trailer may be functional.

Abstract translation: 拖车可以由消费者从商店购买，并且拖车可以快速，容易地并且容易地从商店拖走。 特别地，拖车可以基本上或完全准备好从商店拖走，并且拖车可能不需要或几乎不需要组装。 例如，牵引臂可以快速且容易地从存储位置移动到使用位置。 有利地，因为牵引臂可以通过销连接到拖车，所以不需要工具来将臂定位在使用位置。 此外，因为电线可以设置在臂内，并且当拖车准备被拖曳时，臂可以简单地向前移动，所以拖车的灯可以是功能的。

公开(公告)号：US20060293125A1

公开(公告)日：2006-12-28

申请号：US11453327

申请日：2006-06-14

Applicant: S. Nye ,  David Winter

Inventor： S. Nye ,  David Winter

IPC: A63B63/08

CPC classification number: A63B63/083 ,  A63B2210/50

Abstract: A basketball goal system may include a basketball goal, which may include a rim assembly and a backboard, and a support structure that is sized and configured to support the basketball goal above a playing surface. The backboard may include one or more openings through which one or more portions of the rim assembly may extend, which may permit the rim assembly to be connected to the support structure. The basketball goal system may also include a base that is sized and configured to support the support structure and the rim assembly in a playing position. The base and the backboard may include openings to permit the base and the backboard to be connected when the basketball goal system is in a collapsed or storage position. In addition, the base and the backboard may include receiving portions that are sized and configured to receive and/or retain at least a portion of one or more components of the basketball goal system when the system is in the collapsed position.

Abstract translation: 篮球目标系统可以包括篮球目标，其可以包括轮辋组件和背板，以及支撑结构，其尺寸和构造被配置为支撑篮球目标在游戏表面上方。 背板可以包括一个或多个开口，边缘组件的一个或多个部分可以穿过该开口延伸，这可以允许边缘组件连接到支撑结构。 篮球进球系统还可以包括基座，其大小和构造以支撑支撑结构和轮辋组件处于播放位置。 底座和背板可以包括开口，以便当篮球进球系统处于折叠或储存位置时允许基座和背板连接。 此外，基座和背板可以包括接收部分，其尺寸和构造用于在系统处于折叠位置时接收和/或保持篮球进球系统的一个或多个部件的至少一部分。

公开(公告)号：US20050242314A1

公开(公告)日：2005-11-03

申请号：US10835700

申请日：2004-04-30

Applicant: David Winter

Inventor： David Winter

IPC: F16K1/38 ,  F16K31/02 ,  F16K31/04

CPC classification number: F16K1/38 ,  F16K31/047 ,  Y10S251/903

Abstract: A needle valve assembly for providing fluid flow control includes a motor; an internally threaded valve body; and an externally threaded plunger threadably engaged with the internally threaded valve body and rotatably and reciprocally driven by the motor, wherein the valve body including a fluid inlet, a fluid outlet, and a flow chamber therebetween, the flow chamber including a flow chamber wall and a flow chamber outlet, the plunger including a flexible needle member reciprocating within the flow chamber outlet to provide variable flow control therethrough, the flexible needle member including a lip seal engageable with the flow chamber wall during reciprocation of the plunger and flexible needle member to provide a seal therebetween.

Abstract translation: 用于提供流体流量控制的针阀组件包括马达; 内螺纹阀体; 以及外螺纹柱塞，其与所述内螺纹阀体螺纹地接合并且由所述马达可旋转并往复驱动，其中所述阀体包括流体入口，流体出口和在其间的流动室，所述流动室包括流动室壁和 流动室出口，所述柱塞包括在所述流动室出口内往复运动的柔性针构件以提供可变的流量控制，所述柔性针构件包括在柱塞和柔性针构件往复运动期间可与流动室壁接合的唇形密封件， 之间的密封。

公开(公告)号：US20050223655A1

公开(公告)日：2005-10-13

申请号：US11091837

申请日：2005-03-28

Applicant: Barry Mower ,  Brent Steed ,  Jay Calkin ,  Neil Watson ,  Robert Astle ,  L. Strong ,  Rich Howe ,  David Winter ,  Kent Ashby

Inventor： Barry Mower ,  Brent Steed ,  Jay Calkin ,  Neil Watson ,  Robert Astle ,  L. Strong ,  Rich Howe ,  David Winter ,  Kent Ashby

IPC: E04B1/343 ,  E04B1/61 ,  E04H1/00 ,  E04H1/12 ,  E04H3/00 ,  E04H5/00 ,  E04H6/00 ,  E04H14/00

CPC classification number: E04H1/1205 ,  E04B1/34321 ,  E04B1/61 ,  E04B2001/34389

Abstract: A modular enclosure, such as a shed, may include a number of components. For example, the enclosure may include roof panels, floor panels and wall panels that are connected to the roof and/or floor panels. Preferably, the wall panels span the seams disposed between the roof and/or floor panels. In addition, the wall panels are preferably offset from the roof and/or floor panels. Further, the roof panels, wall panels and floor panels desirably have a substantially similar width. The enclosure may also include one or more corner panels and the corner panels may have a living hinge that generally divides the corner panel in half. Advantageously, the offset connection of the roof panels, wall panels and floor panels may facilitate construction of an enclosure with increased strength and functionality.

Abstract translation: 诸如棚屋的模块化外壳可以包括许多部件。 例如，外壳可以包括连接到屋顶和/或地板面板的屋顶板，地板镶板和墙板。 优选地，壁板跨越设置在屋顶和/或地板之间的接缝。 此外，墙板优选地偏离屋顶和/或地板面板。 此外，屋顶板，墙板和地板板理想地具有基本相似的宽度。 外壳还可以包括一个或多个角板，并且角板可以具有通常将角板分成两半的活动铰链。 有利的是，屋顶板，墙板和地板镶板的偏移连接可以有助于建造具有增加的强度和功能的外壳。