公开(公告)号：US20150129509A1

公开(公告)日：2015-05-14

申请号：US14077930

申请日：2013-11-12

Applicant: David WINTER ,  Gary MERCER ,  Tim A. LANDWEHR ,  Keith LAMBERT

Inventor： David WINTER ,  Gary MERCER ,  Tim A. LANDWEHR ,  Keith LAMBERT

IPC: A47J37/12

CPC classification number: A47J37/1223 ,  A23L5/11 ,  A23L5/17 ,  A47J27/0802 ,  A47J27/0817 ,  A47J27/092 ,  A47J37/1266 ,  A47J37/1285

Abstract: Methods and systems disclosed herein may be methods for rapidly increasing pressure in a pressure fryer cooking vessel during a cooking cycle. Such methods and systems may comprise determining whether a pressure output in the cooking vessel is closed. Such methods and system may also include determining a pressure of the cooking vessel, comparing the pressure of the cooking vessel to a predetermined optimal pressure to determine whether the pressure of the cooking vessel is less than the optimal pressure, and activating a filter pump configured to supply air from a drain pan into the cooking vessel in response to determining that the pressure output is closed and the pressure of the cooking vessel is less than the optimal pressure. Such methods and systems may further include deactivating the filter pump when the pressure within the cooking vessel is equal to or greater than the optimal pressure.

Abstract translation: 本文公开的方法和系统可以是在烹饪周期期间快速增加压力锅炉烹饪容器中的压力的​​方法。 这样的方法和系统可以包括确定烹饪容器中的压力输出是否关闭。 这样的方法和系统还可以包括确定烹饪容器的压力，将烹饪容器的压力与预定的最佳压力进行比较，以确定烹饪容器的压力是否小于最佳压力，以及激活被配置为 响应于确定压力输出关闭并且烹饪容器的压力小于最佳压力，将排水盘的空气供应到烹饪容器中。 这种方法和系统可以进一步包括当烹饪容器内的压力等于或大于最佳压力时，使过滤器泵失活。

公开(公告)号：US08716287B2

公开(公告)日：2014-05-06

申请号：US13697743

申请日：2011-05-12

Applicant: Robert George Boyle ,  David Winter Walker ,  Richard Justin Boyce

Inventor： Robert George Boyle ,  David Winter Walker ,  Richard Justin Boyce

IPC: A61K31/535 ,  C07D241/00

CPC classification number: C07D241/26 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/5377 ,  A61N5/10 ,  C07D241/20 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: A compound of the formula (I):

Abstract translation: 式（I）的化合物：

公开(公告)号：US08440825B2

公开(公告)日：2013-05-14

申请号：US12920923

申请日：2009-03-06

Applicant: Stephen Benedict David Winter ,  Monica Benito Velez

Inventor： Stephen Benedict David Winter ,  Monica Benito Velez

IPC: C07D495/00

CPC classification number: C07D471/08

Abstract: This invention provides a novel dicarboxylic acid salt forms of varenicline, namely varenicline fumarate, and methods for making same. Varenicline salts are useful for treating smoking addition. In one embodiment of the instant invention, the varenicline fumarate shows an XRD pattern (2θ)) (±0.2° having characteristic peaks at 10.6, 11.9, 13.2, 16.2, 16.6, 18.0, 21.5, 22.6, 25.7, 28.5 and 29.1°. In another embodiment, the varenicline fumarate is prepared by (i) contacting varenicline with fumaric acid, optionally in the presence of a suitable solvent, and removing the solvent when necessary, or (ii) contacting varenicline fumarate salt with a suitable solvent, and removing the solvent.

Abstract translation: 本发明提供了一种新的二甲酸盐形式的伐伦尼克林，即富马酸伐曼尼克林及其制备方法。 伐尼克星盐可用于治疗吸烟。 在本发明的一个实施方案中，富马酸伐伦碱显示XRD图谱（2θ））（±0.2°，在10.6,11.9,13.2,16.2,16.6,18.0,21.5,22.6,25.7,28.5和29.1°具有特征峰。 在另一个实施方案中，富马酸伐伦碱通过以下步骤制备：（i）任选地在合适的溶剂存在下使伐伦尼克兰与富马酸接触，并在必要时除去溶剂，或（ii）将富马酸伐伦碱与合适的溶剂接触， 溶剂。

公开(公告)号：US08389724B2

公开(公告)日：2013-03-05

申请号：US13433629

申请日：2012-03-29

Applicant: Stephen Benedict David Winter ,  Monica Benito Velez ,  Ernesto Duran Lopez

Inventor： Stephen Benedict David Winter ,  Monica Benito Velez ,  Ernesto Duran Lopez

IPC: C07D471/00

CPC classification number: C07D487/04

Abstract: This invention provides a novel crystalline sitagliptin ethanedisulfonate salt having the structure set forth below, and a method for using same to treat type 2 diabetes.

Abstract translation: 本发明提供具有下述结构的新型结晶西他列汀乙二磺酸盐及其用于治疗2型糖尿病的方法。

公开(公告)号：US08158808B2

公开(公告)日：2012-04-17

申请号：US12762131

申请日：2010-04-16

Applicant: Stephen Benedict David Winter

Inventor： Stephen Benedict David Winter

IPC: C07D333/16

CPC classification number: C07D333/20

Abstract: The invention relates to an improved process for the preparation of duloxetine, duloxetine intermediates, and duloxetine hydrochloride.

Abstract translation: 本发明涉及一种改进的度洛西汀，度洛西汀中间体和度洛西汀盐酸盐的制备方法。

公开(公告)号：US20100041920A1

公开(公告)日：2010-02-18

申请号：US12505612

申请日：2009-07-20

Applicant: Stephen Benedict David Winter ,  Ernesto Duran Lopez ,  Monica Benito Velez

Inventor： Stephen Benedict David Winter ,  Ernesto Duran Lopez ,  Monica Benito Velez

IPC: C07C211/38 ,  C07C209/44

CPC classification number: C07C309/73 ,  C07C51/412 ,  C07C55/10 ,  C07C59/255 ,  C07C211/42 ,  C07C2602/08

Abstract: The present invention relates generally to novel salt forms of R-(+)-N-propargyl-1-aminoindan (i.e. rasagiline base), to a compound of formula Ia, to processes for their preparation and isolation, and to pharmaceutical compositions comprising the same.

Abstract translation: 本发明一般涉及R - （+） - N-炔丙基-1-氨基茚满（即雷沙吉兰碱）对式Ia化合物的新型盐形式，其制备和分离方法，以及包含 相同。

公开(公告)号：US20090247538A1

公开(公告)日：2009-10-01

申请号：US11577963

申请日：2005-10-25

Applicant: Valerio Berdini ,  Robert George Boyle ,  Gordon Saxty ,  David Winter Walker ,  Steven John Woodhead ,  Paul Graham Wyatt ,  Alastair Donald ,  John Caldwell ,  Ian Collins ,  Tatiana Faria Da Fonseca

Inventor： Valerio Berdini ,  Robert George Boyle ,  Gordon Saxty ,  David Winter Walker ,  Steven John Woodhead ,  Paul Graham Wyatt ,  Alastair Donald ,  John Caldwell ,  Ian Collins ,  Tatiana Faria Da Fonseca

IPC: A61K31/52 ,  C07D473/34 ,  C07D487/04 ,  A61K31/519 ,  C12N9/99 ,  C12Q1/48

CPC classification number: C07D471/04 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  C07D473/34 ,  C07D487/04

Abstract: The invention provides a compound for use as a protein kinase B inhibitor, the compound being a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; J1-J2 is N═C(R6), (R7)C═N, (R8)N—C(O), (R8)2C—C(O), N═N or (R7)C═C(R6); E is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from O, N and S; Q1 is a bond or a saturated C1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by CONRq or NRqCO where Rq is hydrogen or methyl, or Rq is a C1-4 alkylene chain linked to R1 or a carbon atom of Q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group Q1 may optionally bear one or more substituents selected from fluorine and hydroxy; Q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group may optionally bear one or more substituents selected from fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the G group; and provided that when E is aryl or heteroaryl, then Q2 is other than a bond; G is hydrogen, NR2R, OH or SH provided that when E is aryl or heteroaryl and Q2 is a bond, then G is hydrogen; R1 is hydrogen or an aryl or heteroaryl group, with the proviso that when R1 is hydrogen and G is NR2R3, then Q2 is a bond; and R2, R3, R4, R6 and R8 are as defined in the claims.

Abstract translation: 本发明提供用作蛋白激酶B抑制剂的化合物，该化合物为式（I）化合物或其盐，溶剂合物，互变异构体或N-氧化物，其中T为N或CR 5; J1-J2是N-C（R6），（R7）C-N，（R8）N-C（O），（R8）2C-C（O），N-N或（R7）C-C（R6） E是5或6个环成员的单环碳环或杂环基，杂环基含有至多3个选自O，N和S的杂原子; Q1是键或饱和的C 1-3烃连接基团，连接基团中的一个碳原子任选被氧或氮原子代替，或者相邻的一对碳原子可被CONRq或NRqCO代替，其中Rq 是氢或甲基，或Rq是与R1或Q1的碳原子连接的C 1-4亚烷基链，形成环状部分; 并且其中所述连接基团Q1的碳原子可任选地具有一个或多个选自氟和羟基的取代基; Q2是含有1至3个碳原子的键或饱和烃连接基团，其中连接基团中的一个碳原子可任选被氧或氮原子取代; 并且其中所述连接基团的碳原子可以任选地具有一个或多个选自氟和羟基的取代基，条件是当存在的羟基不相对于G基团位于碳原子a时; 并且条件是当E是芳基或杂芳基时，则Q2不是键; G为氢，NR2R，OH或SH，条件是当E为芳基或杂芳基且Q2为键时，则G为氢; R 1是氢或芳基或杂芳基，条件是当R 1是氢且G是NR 2 R 3时，则Q2是一个键; 并且R 2，R 3，R 4，R 6和R 8如权利要求中所定义。

公开(公告)号：US20090182156A1

公开(公告)日：2009-07-16

申请号：US12097245

申请日：2006-12-12

Applicant: Stephen Benedict David Winter

Inventor： Stephen Benedict David Winter

IPC: C07D333/20

CPC classification number: C07D333/20

Abstract: The invention relates to an improved process for the preparation of duloxetine hydrochloride. More particularly, the invention relates to a process for the enantiomeric enrichment of duloxetine, and to a process for increasing the enantiomeric excess of enantiomerically-enriched duloxetine and salts thereof.

Abstract translation: 本发明涉及一种制备度洛西汀盐酸盐的改进方法。 更具体地说，本发明涉及度洛西汀的对映体富集方法，以及增加对映异构体富集的度洛西汀及其盐的对映体过量的方法。

公开(公告)号：US20080275029A1

公开(公告)日：2008-11-06

申请号：US11718943

申请日：2005-11-09

Applicant: Valerio Berdini ,  Robert George Boyle ,  Gordon Saxty ,  Marinus Leendert Verdonk ,  Steven John Woodhead ,  Paul Graham Wyatt ,  Hannah Fiona Sore ,  David Winter Walker ,  John Caldwell ,  Ian Collins

Inventor： Valerio Berdini ,  Robert George Boyle ,  Gordon Saxty ,  Marinus Leendert Verdonk ,  Steven John Woodhead ,  Paul Graham Wyatt ,  Hannah Fiona Sore ,  David Winter Walker ,  John Caldwell ,  Ian Collins

IPC: A61K31/517 ,  C07D239/88 ,  C07D401/12 ,  C07D401/04 ,  A61K31/496 ,  A61K31/551 ,  A61P35/00 ,  C12N5/06 ,  A61K31/5377 ,  C07D401/06 ,  C07D403/12 ,  C07D413/14

CPC classification number: C07D403/12 ,  A61K31/505 ,  C07D239/88 ,  C07D239/91 ,  C07D239/96 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04

Abstract: The invention provides a compound of the formula (I) or a salt, solvate, tautomer or N-oxide thereof for use in the treatment or prophylaxis of a disease state or condition mediated by protein kinase A and/or protein kinase B; wherein the ring Q is a benzene ring; J2-J1 is N═CR7 or R1aN—CO; G is OH or NR5R6; E is CONR7, NR7CO, C(R8)═C(R8) or (X)m(CR8R8a)n where X is O, S or NR7; provided that when J2-J1 is R1aN—CO, E is other than NR7CO; m and n are each 0 or 1, where m+n=1 or 2; A is a bond and R4 and R4a are absent or A is a saturated optionally substituted C1-7 hydrocarbon linker group having a maximum chain length of 5 atoms extending between E and G, one carbon atom in the linker group A being optionally replaced by O or N; R1, R1a, R2, and R3 are each H; halogen; C1-6 hydrocarbyl optionally substituted by halogen, OH or C1-2 alkoxy; CN; CONHR8; NH2; NHCOR10 or NHCONHR10; R4 is H or C1-4 alkyl; R4a is H, C1-4 alkyl or a group R9; R5 and R6 are each selected from H, R9 and C1-4 hydrocarbyl optionally substituted by halogen, C1-2 alkoxy or R9; or NR5R6 forms a saturated 4-7 membered monocyclic heterocyclic group; R7 is H or C1-4 alkyl; R8 and R8a each H or saturated C1-4 hydrocarbyl optionally substituted by fluorine; R9 is a monocyclic or bicyclic carbocyclic or heterocyclic group containing up to 3 ring heteroatoms selected from N, O and S; or R4, R4a and A together form a saturated monocyclic 4-7 membered heterocycle; or NR5R6, R4 and A form a saturated 4-7 membered monocyclic heterocycle; or R4, together with R7 or R8 and A and E form a 4-7 membered saturated monocyclic heterocycle; or NR5R6 and R7 or R8 together with A and E form a 4-7 membered saturated monocyclic heterocycle; and R10 is optionally substituted phenyl or benzyl.

公开(公告)号：US20070213147A1

公开(公告)日：2007-09-13

申请号：US11682247

申请日：2007-03-05

Applicant: S. NYE ,  Carl Stanford ,  Gary Phillips ,  Sharon Jones ,  David Winter ,  L. Strong

Inventor： S. NYE ,  Carl Stanford ,  Gary Phillips ,  Sharon Jones ,  David Winter ,  L. Strong

IPC: A63B63/08

CPC classification number: A63B63/083 ,  A63B2071/025 ,  A63B2071/026 ,  A63B2210/50 ,  A63B2225/093

Abstract: A basketball system may include a basketball goal and a support structure sized and configured to support the basketball goal at a desired height. The basketball goal may include a rim assembly, which may include a ring, one or more rim braces and one or more reinforcing members connected to the ring and the rim braces. The support structure may include a support pole. The basketball system may include a support member connected to a lower end of the support pole, which may form a generally T-shaped configuration. The support member may have a generally rigid construction and may be connected to a support surface to help secure the support pole in a generally fixed position. The basketball system may also include one or more braces that may have a low profile and that may be connected to the support pole and/or the support member.

Abstract translation: 篮球系统可以包括篮球目标和支撑结构，其大小和构造以在期望的高度上支撑篮球目标。 篮球目标可以包括轮辋组件，其可以包括环，一个或多个轮辋支架和连接到所述环和所述轮辋撑杆的一个或多个加强构件。 支撑结构可以包括支撑杆。 篮球系统可以包括连接到支撑杆的下端的支撑构件，其可以形成大致T形的构造。 支撑构件可以具有大致刚性的结构，并且可以连接到支撑表面以帮助将支撑杆固定在大致固定的位置。 篮球系统还可以包括可以具有低轮廓并且可以连接到支撑杆和/或支撑构件的一个或多个支架。