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公开(公告)号：US20070141057A1
公开(公告)日：2007-06-21
申请号：US11633650
申请日：2006-12-04
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K39/395
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US07226593B2
公开(公告)日：2007-06-05
申请号：US10043432
申请日：2002-01-10
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K39/395 , C07K16/28
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α(TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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43.发明申请Methods of treating a blood pathology using anti-TNF antibodies and fragments thereof 失效使用抗TNF抗体及其片段治疗血液病理学的方法公开(公告)号：US20070087003A1
公开(公告)日：2007-04-19
申请号：US11582153
申请日：2006-10-16
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K39/395 , C07K16/24
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US07192584B2
公开(公告)日：2007-03-20
申请号：US09927703
申请日：2001-08-10
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K39/395 , C07K16/28
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: The invention relates to anti-TNF antibodies, fragments, regions and derivatives thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in methods of treating psoriasis, as well as polynucleotides coding for murine and chimeric anti-TNF antibodies, and methods of producing anti-TNF antibodies, fragments, regions and derivatives thereof.
Abstract translation: 本发明涉及对人类肿瘤坏死因子-α（TNFalpha）特异性的抗TNF抗体，其片段，区域和衍生物，可用于治疗牛皮癣的方法，以及编码鼠和嵌合抗TNF抗体的多核苷酸 以及产生抗TNF抗体，其片段，区域和衍生物的方法。
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45.发明授权Methods for treating sarcoidosis using anti-TNF antibodies and fragments thereof 失效使用抗TNF抗体及其片段治疗结节病的方法公开(公告)号：US07135179B2
公开(公告)日：2006-11-14
申请号：US11181030
申请日：2005-07-13
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K39/395 , C07K16/28
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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Patent Agency Ranking
46.发明授权公开(公告)号：US07128908B2
公开(公告)日：2006-10-31
申请号：US11179359
申请日：2005-07-12
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K39/395 , C07K16/28
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
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47.发明申请Methods of treating TNFalpha-mediated tissue injury using anti-TNF antibodies and peptides 失效使用抗TNF抗体和肽治疗TNFα介导的组织损伤的方法公开(公告)号：US20060024310A1
公开(公告)日：2006-02-02
申请号：US11195589
申请日：2005-08-02
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K39/395 , C07H21/04
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US20060018906A1
公开(公告)日：2006-01-26
申请号：US11181030
申请日：2005-07-13
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
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49.发明申请Methods of treating carcinoma using anti-TNF antibodies and fragments thereof 失效使用抗TNF抗体及其片段治疗癌症的方法公开(公告)号：US20050037008A1
公开(公告)日：2005-02-17
申请号：US10957134
申请日：2004-09-30
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: A61K38/00 , C07K14/525 , C07K16/24 , C07K16/30 , A61K39/395
CPC classification number: C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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公开(公告)号：US06277969B1
公开(公告)日：2001-08-21
申请号：US09133119
申请日：1998-08-12
Applicant: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
Inventor： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC: C07H2104
CPC classification number: A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-&agr; (TNF&agr;) and are useful in vivo diagnosis and therapy of a number of TNF&agr;-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。
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