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41.发明申请公开(公告)号：US20050106622A1
公开(公告)日：2005-05-19
申请号：US11023453
申请日：2004-12-29
申请人： Ming-Hui Wei , Karl Guegler , Karen Ketchum , Gennady Merkulov , Trevor Woodage , Valentina Di Francesco , Ellen Beasley
发明人： Ming-Hui Wei , Karl Guegler , Karen Ketchum , Gennady Merkulov , Trevor Woodage , Valentina Di Francesco , Ellen Beasley
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
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公开(公告)号：US20050048612A1
公开(公告)日：2005-03-03
申请号：US10883805
申请日：2004-07-06
申请人： Y. Tang , Preeti Lal , Neil Corley , Karl Guegler , Chandra Patterson , Mariah Baughn , Henry Yue
发明人： Y. Tang , Preeti Lal , Neil Corley , Karl Guegler , Chandra Patterson , Mariah Baughn , Henry Yue
摘要： The invention provides human epidermal proteins (HEP1) and polynucleotides which identify and encode HEP1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HEP1.
摘要翻译： 本发明提供了人表皮蛋白（HEP1）和识别和编码HEP1的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HEP1表达相关的紊乱的方法。
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43.发明授权公开(公告)号：US06780626B2
公开(公告)日：2004-08-24
申请号：US10339657
申请日：2003-01-10
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12Y207/11013
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
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44.发明授权Nucleic acid encoding a fusion protein comprising an EIF-4E domain and an EIF-4G domain joined by a linker domain 失效编码融合蛋白的核酸，其包含通过接头结构域连接的EIF-4E结构域和EIF-4G结构域公开(公告)号：US06703239B2
公开(公告)日：2004-03-09
申请号：US10180196
申请日：2002-06-25
申请人： Karl Guegler , Ruoying Tan , Michael J. Rose
发明人： Karl Guegler , Ruoying Tan , Michael J. Rose
IPC分类号： C12N510
CPC分类号： C12N15/1096
摘要： Methods and compositions are provided for producing full-length cDNA libraries. In the subject methods, full length first strand cDNAs are isolated using a fusion protein of an eIF-4E domain and an eIF-4G domain separated by a flexible linker. Also provided is the novel fusion protein employed in the subject methods, as well as nucleic acids encoding, and host cells capable of expressing, the same. Finally, kits for use in practicing the subject methods are provided. The subject invention finds use in a variety of applications in which full-length cDNA libraries are employed.
摘要翻译： 提供了用于产生全长cDNA文库的方法和组合物。 在本发明方法中，使用eIF-4E结构域和由柔性接头分离的eIF-4G结构域的融合蛋白分离全长第一链cDNA。 还提供了本发明方法中使用的新型融合蛋白，以及编码的核酸和能够表达相同的宿主细胞。 最后，提供了用于实践主题方法的工具包。 本发明可用于其中使用全长cDNA文库的各种应用中。
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45.发明授权Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof 失效分离的人磷脂酶蛋白，编码人磷脂酶蛋白的核酸分子及其用途公开(公告)号：US06689598B2
公开(公告)日：2004-02-10
申请号：US10096961
申请日：2002-03-14
IPC分类号： C12N920
CPC分类号： C12N9/20 , A01K2217/05 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
摘要翻译： 本发明提供由人基因组内的基因编码的肽的氨基酸序列，本发明的磷脂酶肽。 本发明具体提供分离的肽和核酸分子，鉴定磷脂酶肽的直系同源物和旁系同源物的方法，以及鉴定磷脂酶肽调节剂的方法。
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公开(公告)号：US06689597B2
公开(公告)日：2004-02-10
申请号：US10135687
申请日：2002-05-01
申请人： Ishwar Chandramouliswaran , Karl Guegler , Marion Webster , Chunhua Yan , Valentina Di Francesco , Ellen M. Beasley
发明人： Ishwar Chandramouliswaran , Karl Guegler , Marion Webster , Chunhua Yan , Valentina Di Francesco , Ellen M. Beasley
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12Y207/11001
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
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47.发明授权公开(公告)号：US06528294B2
公开(公告)日：2003-03-04
申请号：US10060332
申请日：2002-02-01
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12Y207/11013
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
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48.发明授权公开(公告)号：US06416990B2
公开(公告)日：2002-07-09
申请号：US09732025
申请日：2000-12-08
申请人： Ming-Hui Wei , Karl Guegler , Karen A. Ketchum , Gennady V. Merkulov , Trevor Woodage , Valentina Di Francesco , Ellen M. Beasley
发明人： Ming-Hui Wei , Karl Guegler , Karen A. Ketchum , Gennady V. Merkulov , Trevor Woodage , Valentina Di Francesco , Ellen M. Beasley
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
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49.发明授权公开(公告)号：US06410294B1
公开(公告)日：2002-06-25
申请号：US09734673
申请日：2000-12-13
IPC分类号： C12N912
CPC分类号： C12N9/1205
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
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50.发明授权Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof 失效分离的人磷脂酶蛋白，编码人磷脂酶蛋白的核酸分子及其用途公开(公告)号：US06391606B1
公开(公告)日：2002-05-21
申请号：US09738884
申请日：2000-12-18
IPC分类号： C12N920
CPC分类号： C12N9/20 , A01K2217/05 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
摘要翻译： 本发明提供由人基因组内的基因编码的肽的氨基酸序列，本发明的磷脂酶肽。 本发明具体提供分离的肽和核酸分子，鉴定磷脂酶肽的直系同源物和旁系同源物的方法，以及鉴定磷脂酶肽调节剂的方法。
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