公开(公告)号：US07763460B2

公开(公告)日：2010-07-27

申请号：US11296571

申请日：2005-12-06

Applicant: Xin Su ,  Lilly Kong ,  Wayne Hogrefe

Inventor： Xin Su ,  Lilly Kong ,  Wayne Hogrefe

IPC: C12N5/06

CPC classification number: C07K14/005 ,  C12N2710/16622 ,  G01N33/56994

Abstract: The invention provides methods for sensitive and specific detection of anti-HSV-2 antibodies by depletion of cross-reactive (non-specific) antibodies in a biological sample that can lead to a false positive result. The invention also features compositions, including nucleic acids, polypeptides, and kits, for use in the methods of the invention.

Abstract translation: 本发明提供了通过消耗生物样品中可能导致假阳性结果的交叉反应性（非特异性）抗体来敏感和特异性检测抗HSV-2抗体的方法。 本发明还包括用于本发明方法的组合物，包括核酸，多肽和试剂盒。

公开(公告)号：US20050112708A1

公开(公告)日：2005-05-26

申请号：US10846380

申请日：2004-05-13

Applicant: Harry Prince ,  Xin Su ,  Lilly Kong ,  Ken Devor ,  Sergei Arakelov ,  Wayne Hogrefe ,  Celine Ngo

Inventor： Harry Prince ,  Xin Su ,  Lilly Kong ,  Ken Devor ,  Sergei Arakelov ,  Wayne Hogrefe ,  Celine Ngo

IPC: C07K14/37 ,  G01N33/569 ,  G01N33/53

CPC classification number: B82Y5/00 ,  B82Y10/00 ,  C07K14/37 ,  G01N33/56961 ,  G01N2469/10 ,  G01N2469/20

Abstract: The present invention relates to oxidized fungal antigens and methods of making and using thereof. More particularly, the present invention provides a method for producing an oxidized fungal antigen in culture filtrate. The present invention also provides for the produced oxidized fungal antigens. Devices comprising such oxidized fungal antigens, methods for testing for fungal antibodies using the oxidized fungal antigens and methods for producing anti-fungal antibodies using oxidized fungal antigens are further provided. Antigen detection devices comprising anti-fungal antibodies raised against oxidized fungal antigens produced by the present methods are further provided.

Abstract translation: 本发明涉及氧化真菌抗原及其制备和使用方法。 更具体地，本发明提供了在培养滤液中生产氧化真菌抗原的方法。 本发明还提供了所产生的氧化真菌抗原。 还提供了包含这种氧化真菌抗原的装置，使用氧化真菌抗原检测真菌抗体的方法和使用氧化真菌抗原产生抗真菌抗体的方法。 进一步提供包含通过本方法产生的抗氧化真菌抗原产生的抗真菌抗体的抗原检测装置。