公开(公告)号：US20240279688A1

公开(公告)日：2024-08-22

申请号：US18568235

申请日：2022-06-06

申请人： Novozymes A/S

发明人： Hamid Rismani YAZDI ,  Eric Allain ,  Michael Glenn Catlett ,  Christie Lynn Strahler

IPC分类号： C12P7/06 ,  C07K14/37 ,  C12N1/14 ,  C12N9/02 ,  C12N9/30 ,  C12N9/34

CPC分类号： C12P7/06 ,  C07K14/37 ,  C12N1/145 ,  C12N9/0008 ,  C12N9/242 ,  C12N9/2428 ,  C12Y102/01009 ,  C12Y302/01001 ,  C12Y302/01003

摘要： Described herein are recombinant host organisms expressing a glucose or glycerol transporter, and optionally further expressing a non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (GAPN). Also described are processes for producing a fermentation product, such as ethanol, from starch or cellulosic-containing material with the recombinant host organisms.

公开(公告)号：US20240272170A1

公开(公告)日：2024-08-15

申请号：US18365185

申请日：2023-08-03

申请人： Quantum-Si Incorporated

发明人： Brian Reed ,  Manjula Pandey ,  Marco Ribezzi-Crivellari ,  Douglas Pike ,  Jennifer Tullman ,  Kristin Blacklock ,  Adeline Pichard-Kostuch ,  Ahmed Rehan ,  Mohammad Wadud Bhuiya

IPC分类号： G01N33/68 ,  C07K14/37

CPC分类号： G01N33/6824 ,  C07K14/37

摘要： There is provided amino acid recognizers with improved binding properties, allowing for more structural information to be obtained from polypeptides based on the kinetics of on-off binding between recognizer and polypeptide. An amino acid recognizer may comprise an amino acid binding protein with an engineered binding pocket having one or more modifications relative to a homologous protein. The modified binding pocket may increase the number of interactions formed between the binding pocket and an amino acid ligand as compared to an unmodified binding pocket of the homologous protein, increase the number of types of amino acid ligands capable of being detectably bound as compared to an unmodified binding pocket of the homologous protein, and improve the kinetics of binding (e.g., KD, koff, kon) toward one or more types of amino acid ligands, which advantageously increases the amount of, or confidence in, structural information that may be derived from polypeptide analysis.

公开(公告)号：US12053002B2

公开(公告)日：2024-08-06

申请号：US17682874

申请日：2022-02-28

申请人： WILD EARTH, INC.

发明人： Ron Shigeta ,  Ryan Bethencourt ,  Abril Estrada

IPC分类号： A23K40/00 ,  A23J1/00 ,  A23K10/16 ,  A23K10/18 ,  A23K20/147 ,  A23K20/158 ,  C07K14/37 ,  C07K14/38 ,  C07K14/395

CPC分类号： A23K10/16 ,  A23J1/008 ,  A23K10/18 ,  A23K20/147 ,  A23K20/158 ,  A23K40/00 ,  C07K14/37 ,  C07K14/38 ,  C07K14/395

摘要： The present disclosure provides a composition comprising, (i) protein at a protein content of at least about 16% by dry weight, wherein at least about 50% by dry weight of the protein has an amino acid sequence encoded by one or more fungal genomes, and (ii) one or more materials selected from the group consisting of a flour, an oil, a flavoring agent, and a nutritional supplement, wherein the composition has a water content that is less than or equal to about 30% water by weight.

公开(公告)号：US20240043479A1

公开(公告)日：2024-02-08

申请号：US18381047

申请日：2023-10-17

申请人： University of Oregon

发明人： Matthew Barber ,  Caitlin Kowalski

IPC分类号： C07K14/37 ,  A61P31/04

CPC分类号： C07K14/37 ,  A61P31/04 ,  A61K38/00

摘要： Compositions including an antibiotic factor from Malassezia are provided. In some examples, the compositions include a Malassezia exoproduct, a Malassezia cell-free supernatant, or a Malassezia cell and a pharmaceutically acceptable carrier. Methods of treating an infection in a subject, such as a Staphylococcus infection are also provided.

公开(公告)号：US20230416768A1

公开(公告)日：2023-12-28

申请号：US17791253

申请日：2021-01-06

申请人： WOODLIGHT

发明人： Rose-Marie VESIN-AUCLAIR

IPC分类号： C12N15/82 ,  C07K14/37

CPC分类号： C12N15/8243 ,  C07K14/37 ,  C12N15/8206 ,  C12N15/8213

摘要： The present invention relates to a method of making bioluminescent plants by introducing luciferase genes and luciferin biosynthesis genes into plant chloroplasts.

公开(公告)号：US20230272019A1

公开(公告)日：2023-08-31

申请号：US18050485

申请日：2022-10-28

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

发明人： Yousong Ding ,  Peilan Zhang ,  Steven Douglas Bruner

IPC分类号： C07K14/37 ,  A61P35/02 ,  A61P35/00 ,  A61K38/16 ,  G01N33/574

CPC分类号： C07K14/37 ,  A61P35/02 ,  A61P35/00 ,  A61K38/16 ,  G01N33/57484

摘要： The subject invention pertains to compositions and methods for preparing and using recombinant proteins based on the fungal Coprinus comatus Y3 protein to control plant and animal viruses and microbes, and diagnose, prevent and treat cancers. Methods are disclosed using compositions comprising recombinant Y3 proteins to diagnose, prevent and/or treat cancer diseases based on recombinant Y3 protein interaction with glycans expressed on cancer cells.

公开(公告)号：US20230174998A1

公开(公告)日：2023-06-08

申请号：US17919435

申请日：2021-04-09

申请人： DANISCO US INC.

发明人： Yun Luo ,  Igor Nikolaev ,  Robert James Pratt, II

IPC分类号： C12N15/80 ,  C12N1/14 ,  C07K14/37 ,  C12N9/42

CPC分类号： C12N15/80 ,  C12N1/14 ,  C07K14/37 ,  C12N9/2437 ,  C12R2001/885

摘要： The present disclosure is generally related to mutant and genetically modified filamentous fungal cells and methods thereof for use in the production of proteins of interest. More particularly, as described herein, the mutant and/or modified fungal cells (strains) of the disclosure are well-suited for use in industrial scale fermentation processes for the enhanced expression/production of proteins of interest in the absence and/or in the presence of an inducing substrate.

公开(公告)号：US20230145729A1

公开(公告)日：2023-05-11

申请号：US17995191

申请日：2021-03-31

申请人： GRASSLANZ TECHNOLOGY LIMITED

发明人： Alison Jean POPAY ,  Debbie Anne HUDSON ,  Richard David JOHNSON ,  Sarah Christine FINCH ,  Wade Jeffery MACE

IPC分类号： C12N15/80 ,  C07K14/37 ,  C12N1/14 ,  C12N15/52 ,  C12P17/18

CPC分类号： C12N15/80 ,  C07K14/37 ,  C12N1/145 ,  C12N15/52 ,  C12P17/188 ,  C12R2001/645

摘要： The present invention generally relates to methods of producing one or more indole diterpene compounds in the epoxy janthitrem biosynthetic pathway and polynucleotides, polypeptides, expression constructs and host cells useful in the production of one or more indole diterpene compounds, and methods of using same to confer a benefit to an organism, such as increased insect pest resistance.

公开(公告)号：US20180273589A1

公开(公告)日：2018-09-27

申请号：US15542104

申请日：2016-01-08

申请人： UNIVERSITY OF CINCINNATI

发明人： Christian HONG ,  Toru MATSUURA

IPC分类号： C07K14/37 ,  C12P7/10 ,  C12N15/80 ,  C12N9/42 ,  C12P19/02 ,  C12P19/14

CPC分类号： C07K14/37 ,  C12N9/2437 ,  C12N15/80 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12P2203/00 ,  C12Y101/99018 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16

摘要： Transgenic strains of Neurospora crassa engineered to comprise a synthetic positive feedback loop for a transcriptional activator of cellulase expression such that cellulase production is amplified are disclosed, along with compositions thereof. The transgenic strains are particularly useful in methods for generating purified cellulases, fermentable sugars, and cellulosic ethanol for the efficient production of biofuel from cellulose-containing biomass and waste.

公开(公告)号：US20180245117A1

公开(公告)日：2018-08-30

申请号：US15912817

申请日：2018-03-06

申请人： DANISCO US INC

发明人： MICHAEL BODO ,  MENG HONG HENG

IPC分类号： C12P19/44 ,  C12P7/64 ,  C07K14/37

CPC分类号： C12P19/44 ,  C07K14/37 ,  C12P7/64

摘要： The invention relates to a method for decreasing foam formation as well as maximizing expression of a biosurfactant in a microorganism. The methods encompasses precipitating a biosurfactant from the microorganism which results in decreased form formation.