公开(公告)号：US5008260A

公开(公告)日：1991-04-16

申请号：US167153

申请日：1988-03-16

Applicant: Hiroshi Yamauchi ,  Isao Sugiyama ,  Isao Saito ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Shigeto Negi

Inventor： Hiroshi Yamauchi ,  Isao Sugiyama ,  Isao Saito ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Shigeto Negi

IPC: C07D471/08 ,  C07D501/46

CPC classification number: C07D471/08

Abstract: Described herein is a cephem derivative represented by the general formula: ##STR1## wherein n stands for 1 or 2, Y stands for CH or nitrogen atom, R.sub.1 represents a lower hydrocarbon group or a carboxyl-substituted, a carbamoyl-substituted, or a cyclopropyl-substituted lower alkyl group, and R.sub.2 denotes hydroxyl group, a lower alkyl group, a hydroxy-substituted lower alkyl group, or carbamoyl group. The derivative is useful as an antibacterial agent. Also described herein are processes for the production of the derivative, antibacterial composition, intermediate of the derivative and process for the production thereof.

公开(公告)号：US4285941A

公开(公告)日：1981-08-25

申请号：US142160

申请日：1980-04-14

Applicant: Yoshimasa Machida ,  Isao Saito ,  Seiichiro Nomoto ,  Shigeto Negi ,  Takeo Kanai ,  Kyosuke Kitoh ,  Kanemasa Katsu ,  Yukio Ohya ,  Takeshi Nagasu

Inventor： Yoshimasa Machida ,  Isao Saito ,  Seiichiro Nomoto ,  Shigeto Negi ,  Takeo Kanai ,  Kyosuke Kitoh ,  Kanemasa Katsu ,  Yukio Ohya ,  Takeshi Nagasu

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D311/22 ,  C07D501/36

CPC classification number: C07D311/22

Abstract: Novel cephalosporin compounds of the general formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted nitrogen-containing heterocyclic-thio group, R.sub.2 represents hydrogen or hydroxy, and R.sub.3, R.sub.4 and R.sub.5 each represents hydrogen, hydroxy or acyloxy, and their salts, and processes for the preparation thereof. The novel compounds and their salts have antibacterial activity.

Abstract translation: 新型头孢菌素化合物，其通式如下：其中R 1表示取代或未取代的含氮杂环硫基，R 2表示氢或羟基，R 3，R 4和R 5各自表示氢，羟基或酰氧基， 及其制备方法。 新化合物及其盐具有抗菌活性。