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公开(公告)号：US20100041633A1
公开(公告)日：2010-02-18
申请号：US12526005
申请日：2008-01-28
申请人： Francesca Benedini , Stefano Biondi , Ennio Ongini
发明人： Francesca Benedini , Stefano Biondi , Ennio Ongini
IPC分类号： A61K31/58 , C07J9/00 , A61K31/565 , A61P9/10
CPC分类号： C07J41/005
摘要： The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is a corticosteroid residue selected from: The compounds are useful in the treatment of respiratory diseases.
摘要翻译： 本发明涉及通式（I）的皮质类固醇及其药学上可接受的盐或立体异构体的硝基氧基衍生物，其中R是选自以下的皮质类固醇残基：该化合物可用于治疗呼吸系统疾病。
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42.发明申请公开(公告)号：US20080200479A1
公开(公告)日：2008-08-21
申请号：US11816631
申请日：2006-02-24
IPC分类号： A61K31/5025 , C07D235/00 , A61P25/18
CPC分类号： C07D471/04
摘要： The invention relates to new salts of ocaperidone and uses thereof, particularly in the pharmaceutical industry. The invention discloses specific salts of ocaperidone having increased water solubilities, as well as therapeutic methods by administering said salts, in particular for treating various diseases of the central or peripheral nervous system, especially central nervous system. It further deals with pharmaceutical compositions comprising said salts and methods for preparing the same.
摘要翻译： 本发明涉及α-磷脂酰胺的新盐及其用途，特别是在制药工业中。 本发明公开了具有增加的水溶性的奥美酮特异性盐，以及通过施用所述盐，特别是用于治疗中枢或周围神经系统，特别是中枢神经系统的各种疾病的治疗方法。 它还涉及包含所述盐的药物组合物及其制备方法。
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公开(公告)号：US5705636A
公开(公告)日：1998-01-06
申请号：US570820
申请日：1995-12-12
IPC分类号： B01J31/02 , B01J31/12 , C07B61/00 , C07D205/04 , C07D205/08
CPC分类号： C07D205/08 , Y02P20/55
摘要： Compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen or a nitrogen protecting group, useful as intermediates in the preparation of compounds having antibacterial activity.
摘要翻译： 式（I）的化合物，其中R 1表示氢或氮保护基，可用作制备具有抗菌活性的化合物的中间体。
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公开(公告)号：US5138048A
公开(公告)日：1992-08-11
申请号：US578949
申请日：1990-09-07
申请人： Bruno Tamburini , Alcide Perboni , Tino Rossi , Daniele Donati , Daniele Andreotti , Giovanni Gaviraghi , Stefano Biondi , Claudio Bismara
发明人： Bruno Tamburini , Alcide Perboni , Tino Rossi , Daniele Donati , Daniele Andreotti , Giovanni Gaviraghi , Stefano Biondi , Claudio Bismara
IPC分类号： C07D487/04 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/407 , A61P31/04 , C07C45/71 , C07C49/753 , C07D205/08 , C07D477/00 , C07D487/00 , C07F7/18
CPC分类号： C07D477/00 , C07C45/71 , C07C49/753 , C07D205/08 , C07F7/186 , Y02P20/55
摘要： Compounds of the general formula (I) ##STR1## in which: R.sub.1 represents a hydroxyl protecting group; andR.sub.2 represents a hydrogen or halogen atom, an azido group, a C.sub.1-3 alkyl group, a group (CH.sub.2).sub.m OR.sub.3 wherein m is zero or one and R.sub.3 represents a hydrogen atom or a hydroxyl protecting group, an azidoethoxy group, a protected hydroxyethoxy group or a group XR.sub.4 in which X is an oxygen atom or the group S(O).sub.n in which n is zero, 1 or 2 and R.sub.4 represents a C.sub.1-5 alkyl, C.sub.3-7 cycloalkyl or phenyl group or when X is oxygen or sulphur then R.sub.4 may also represent the group AlkNR.sub.5 R.sub.6 in which Alk represents a C.sub.2-6 straight or branched alkylene chain and R.sub.5 and R.sub.6 independently represent a hydrogen atom or C.sub.1-4 alkyl group or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino ring or the group NR.sub.5 R.sub.6 represents a protected amino group, or R.sub.2 represents the group (CH.sub.2).sub.m NR.sub.7 R.sub.8 in which m is zero or 1 and R.sub.7 and R.sub.8 independently represent a hydrogen atom or a C.sub.1-4 alkyl group or NR.sub.7 R.sub.8 represents a protected amino group, or R.sub.2 and the carbon atom to which it is attached represent a keto group or a ketal derivative thereof; and acid addition salts of such compounds containing basic centers.
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